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Author Details

Anang A Shelat
St. Jude Children's Research Hospital
2003
94
34
Nathan Sheffield (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37925158A high-throughput quality control method for assessing the serial dilution performance of dose-response plates with acoustic ejection mass spectrometry.SLAS Technol2024
36318650Combination of Ribociclib with BET-Bromodomain and PI3K/mTOR Inhibitors for Medulloblastoma Treatment In Vitro and In Vivo.Mol Cancer Ther2023
37596258The net electrostatic potential and hydration of ABCG2 affect substrate transport.Nat Commun2023
37849548Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors.ACS Med Chem Lett2023
36971093ATM inhibition enhances the efficacy of radiation across distinct molecular subgroups of pediatric high-grade glioma.Neuro Oncol2023
36781850Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia.Nat Commun2023
36894563Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia.Nat Commun2023
36493759Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.Cell Chem Biol2022
33453364Evaluating and evolving a screening library in academia: the St Jude approach.Drug Discov Today2021
33512458Modeling and targeting of erythroleukemia by hematopoietic genome editing.Blood2021
33618772MAIP: a web service for predicting blood-stage malaria inhibitors.J Cheminform2021
34589567Data vignettes for the application of response surface models in drug combination analysis.Data Brief2021
34614283Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.Angew Chem Int Ed Engl2021
34413129SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents.Mol Cancer Ther2021
33939327Model-based evaluation of image-guided fractionated whole-brain radiation therapy in pediatric diffuse intrinsic pontine glioma xenografts.CPT Pharmacometrics Syst Pharmacol2021
34215733Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.Nat Commun2021
34119666Using response surface models to analyze drug combinations.Drug Discov Today2021
34197833Small Molecule Sequestration of the Intrinsically Disordered Protein, p27<sup>Kip1</sup>, Within Soluble Oligomers.J Mol Biol2021
32198459A critical evaluation of methods to interpret drug combinations.Sci Rep2020
3349090417-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma.iScience2020
32060267MYCN amplification and ATRX mutations are incompatible in neuroblastoma.Nat Commun2020
32067270ABCG2 requires a single aromatic amino acid to "clamp" substrates and inhibitors into the binding pocket.FASEB J2020
32795876A phase I trial of talazoparib and irinotecan with and without temozolomide in children and young adults with recurrent or refractory solid malignancies.Eur J Cancer2020
32651255Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer.Cancer Res2020
30611980Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents.Eur J Med Chem2019
31251562Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway.ACS Chem Biol2019
30395907Combinatorial screening using orthotopic patient derived xenograft-expanded early phase cultures of osteosarcoma identify novel therapeutic drug combinations.Cancer Lett2019
29170024Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.Bioorg Med Chem2018
30146332Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses.Cancer Cell2018
29769641Erratum: BRAID: A Unifying Paradigm for the Analysis of Combined Drug Action.Sci Rep2018
29605436The role of ZA channel water-mediated interactions in the design of bromodomain-selective BET inhibitors.J Mol Graph Model2018
29407975Novel vitexin-inspired scaffold against leukemia.Eur J Med Chem2018
28985478Alteration of RNA Splicing by Small-Molecule Inhibitors of the Interaction between NHP2L1 and U4.SLAS Discov2018
29301833Establishing a Preclinical Multidisciplinary Board for Brain Tumors.Clin Cancer Res2018
28787124Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway.ACS Chem Biol2017
28257198Shared Consensus Machine Learning Models for Predicting Blood Stage Malaria Inhibition.J Chem Inf Model2017
29287089Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening.PLoS Negl Trop Dis2017
28538182Targeting Metabolic Reprogramming by Influenza Infection for Therapeutic Intervention.Cell Rep2017
28854174Orthotopic patient-derived xenografts of paediatric solid tumours.Nature2017
28581483Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.Nat Chem Biol2017
28684529Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox.Cancer Res2017
26138443Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1.Cell Death Differ2016
26518542Preclinical studies of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in pediatric brain tumors.J Neurooncol2016
27165106Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum.Malar J2016
27160857BRAID: A Unifying Paradigm for the Analysis of Combined Drug Action.Sci Rep2016
27125973Evaluation of artemisinins for the treatment of acute myeloid leukemia.Cancer Chemother Pharmacol2016
26886014Robust Classification of Small-Molecule Mechanism of Action Using a Minimalist High-Content Microscopy Screen and Multidimensional Phenotypic Trajectory Analysis.PLoS One2016
26802024The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease.Oncotarget2016
26820555Synthesis and evaluation of colletoic acid core derivatives.Eur J Med Chem2016
26068307The Childhood Solid Tumor Network: A new resource for the developmental biology and oncology research communities.Dev Biol2016
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Collaborators

Taosheng Chen
St. Jude Children's Research Hospital
Co-authored papers 20
Martine F Roussel
St. Jude Children's Research Hospital
Co-authored papers 12
Elizabeth Stewart
St Jude Children's Research Hospital
Co-authored papers 12
Wenwei Lin
St. Jude Children's Research Hospital
Co-authored papers 9
Alberto S Pappo
St Jude Children's Research Hospital
Co-authored papers 8
Amar Gajjar
St. Jude Children's Research Hospital
Co-authored papers 6
Xiang Chen
St. Jude Children's Research Hospital
Co-authored papers 6
Jinghui Zhang
Changhai Hospital, Second Military Medical University
Co-authored papers 5
Duane G Currier
St. Jude Children's Research Hospital
Co-authored papers 5
Giles W Robinson
St. Jude Children's Research Hospital
Co-authored papers 4
Richard K Wilson
The Ohio State University
Co-authored papers 4
James H McKerrow
Sandler Center for Drug Discovery, University of California San Francisco
Co-authored papers 4
Elaine R Mardis
The Ohio State University
Co-authored papers 4
John Easton
St Jude Children's Research Hospital
Co-authored papers 4
Chunxu Qu
Co-authored papers 4
Richard J Gilbertson
Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 4
Joseph L DeRisi
University of California San Francisco
Co-authored papers 3
Amos Hong Pheng Loh
Co-authored papers 3
Xin Zhou
St. Jude Children's Research Hospital
Co-authored papers 3
Conor R Caffrey
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 3
Suzanne J Baker
Co-authored papers 3
Ji-Hoon Cho
Co-authored papers 3
Christopher Calabrese
St. Jude Children's Research Hospital
Co-authored papers 3
Su Sien Ong
St. Jude Children's Research Hospital
Co-authored papers 2
Robert J Fletterick
University of California San Francisco
Co-authored papers 2
Phuong Nguyen
Hoag Memorial Hospital Presbyterian
Co-authored papers 2
Sima Jeha
St. Jude Children's Research Hospital
Co-authored papers 2
Geoffrey Neale
St. Jude Children's Research Hospital
Co-authored papers 2
Jie J Zheng
Molecular Biology Institute, University of California los angeles
Co-authored papers 2
James M Olson
Clinical Research Division, Fred Hutchinson Cancer Center
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