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Author Details

Frances M Sladek
University of California riverside
1989
72
43
PMIDPaper TitleJournal TitlePublished Year
37400966Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice.Gut Microbes2023
37635981Multiple roles and regulatory mechanisms of the transcription factor HNF4 in the intestine.Front Endocrinol (Lausanne)2023
37600688HNF4α isoforms: the fraternal twin master regulators of liver function.Front Endocrinol (Lausanne)2023
35947136Hepatic circadian and differentiation factors control liver susceptibility for fatty liver disease and tumorigenesis.FASEB J2022
33039560Palmitic acid negatively regulates tumor suppressor PTEN through T366 phosphorylation and protein degradation.Cancer Lett2021
31912136Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice.Endocrinology2020
31191316Dimethyl Sulfoxide Decreases Levels of Oxylipin Diols in Mouse Liver.Front Pharmacol2019
31575546HNF4α-Deficient Fatty Liver Provides a Permissive Environment for Sex-Independent Hepatocellular Carcinoma.Cancer Res2019
29510228Conservation of DNA and ligand binding properties of retinoid X receptor from the placozoan Trichoplax adhaerens to human.J Steroid Biochem Mol Biol2018
30341289Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma.Nat Commun2018
28719624Sequence-specific DNA binding by MYC/MAX to low-affinity non-E-box motifs.PLoS One2017
28970503Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice.Sci Rep2017
27166517Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer.Elife2016
26240283Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells.Mol Cell Biol2015
26200659Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver.PLoS One2015
22383578Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors.Nucleic Acids Res2012
22731903HNF4α: a new biomarker in colon cancer?Biomark Med2012
22895168The yin and yang of proliferation and differentiation: cyclin D1 inhibits differentiation factors ChREBP and HNF4α.Cell Cycle2012
22458515The transcription factor encyclopedia.Genome Biol2012
22308320Src tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer.Proc Natl Acad Sci U S A2012
20615454What are nuclear receptor ligands?Mol Cell Endocrinol2011
22085832Nuclear receptor HNF4α binding sequences are widespread in Alu repeats.BMC Genomics2011
20054869Integrated approach for the identification of human hepatocyte nuclear factor 4alpha target genes using protein binding microarrays.Hepatology2010
20833107HNF4α--role in drug metabolism and potential drug target?Curr Opin Pharmacol2010
19179483Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs.Mol Endocrinol2009
19440305Identification of an endogenous ligand bound to a native orphan nuclear receptor.PLoS One2009
17885207Nuclear receptor hepatocyte nuclear factor 4alpha1 competes with oncoprotein c-Myc for control of the p21/WAF1 promoter.Mol Endocrinol2008
17996499Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas.Gene Expr Patterns2008
17123746Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters.Gene2007
17389749Phosphorylation of a conserved serine in the deoxyribonucleic acid binding domain of nuclear receptors alters intracellular localization.Mol Endocrinol2007
16377800Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.J Biol Chem2006
17132856International Union of Pharmacology. LXVI. Orphan nuclear receptors.Pharmacol Rev2006
16714383Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver.Proc Natl Acad Sci U S A2006
16895524Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4alpha (HNF4alpha) gene.Biochem J2006
16601232AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress.Arterioscler Thromb Vasc Biol2006
16618389Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon.Gastroenterology2006
15752752Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells.Biochem Biophys Res Commun2005
14729646Development of a cancer-targeted tissue-specific promoter system.Cancer Res2004
12514134MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300.EMBO J2003
14498828Nuclear receptors as drug targets: new developments in coregulators, orphan receptors and major therapeutic areas.Expert Opin Ther Targets2003
11818510Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity.Mol Endocrinol2002
12385991Identifying transcription factor binding sites through Markov chain optimization.Bioinformatics2002
12205093Developmentally regulated N-terminal variants of the nuclear receptor hepatocyte nuclear factor 4alpha mediate multiple interactions through coactivator and corepressor-histone deacetylase complexes.J Biol Chem2002
12191466Desperately seeking...something.Mol Cell2002
12089346Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205.Mol Endocrinol2002
11865043Competitive cofactor recruitment by orphan receptor hepatocyte nuclear factor 4alpha1: modulation by the F domain.Mol Cell Biol2002
11679969Lipopolysaccharide results in a marked decrease in hepatocyte nuclear factor 4 alpha in rat liver.Hepatology2001
11090049Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression.Blood2000
10993727Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha.J Mol Biol2000
10490591Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4alpha1.Mol Cell Biol1999
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Collaborators

Chuhu Yang
Oriomics Inc. Hangzhou
Co-authored papers 6
Tao Jiang
University of California riverside
Co-authored papers 5
John Y-J Shyy
Co-authored papers 2
Michael Wegner
Institut fur Biochemie, Friedrich-Alexander-Universitat Erlangen-Nurnberg
Co-authored papers 1
John W Newman
University of California Davis
Co-authored papers 1
Fred E Cohen
University of California san francisco
Co-authored papers 1
Maria-Elena Torres-Padilla
Institute of Epigenetics and Stem Cells (IES)
Co-authored papers 1
Dominique Leprince
University Lille, CNRS, INSERM
Co-authored papers 1
Bryce M Paschal
University of Virginia School of Medicine
Co-authored papers 1
Roy S Herbst
Yale School of Medicine
Co-authored papers 1
Dino Moras
Laboratory IGBMC (Institute of Genetics and of Molecular and Cellular Biology)
Co-authored papers 1
Capucine Van Rechem
Stanford University School of Medicine
Co-authored papers 1
Geoffrey S Ginsburg
National Institutes of Health
Co-authored papers 1
A A Bogan
University of California san francisco
Co-authored papers 1
Frank J Gonzalez
Co-authored papers 1
Robert F Hevner
university of california san diego School of Medicine, University of California
Co-authored papers 1
Michael M Allevato
University of Michigan Medical School.
Co-authored papers 1
Oliver Fiehn
University of California davis
Co-authored papers 1
Kyle Ellrott
Oregon Health & Science University
Co-authored papers 1
Frank C Kuo
Co-authored papers 1
Songqin Pan
Co-authored papers 1
Klaus H Kaestner
Department of Genetics and Institute for Diabetes, University of Pennsylvania
Co-authored papers 1
Zhongming Zhao
Center for Precision Health, The University of Texas Health Science Center at Houston
Co-authored papers 1
Gaylor Boulay
Massachusetts General Hospital and Harvard Medical School
Co-authored papers 1
Yulin Dai
The University of Texas Health Science Center at Houston.
Co-authored papers 1
Satrajit Sinha
Jacobs School of Medicine and Biomedical Sciences, University at Buffalo
Co-authored papers 1
Wyeth W Wasserman
BC Children's Hospital Research Institute, University of British Columbia
Co-authored papers 1
Peggy J Farnham
Keck School of Medicine of USC
Co-authored papers 1
Vincent Laudet
Okinawa Institute of Science and Technology
Co-authored papers 1
Ghassan S Kassab
California Medical Innovations Institute
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Release 1.2