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Author Details

Benjamin F Cravatt
Scripps Research Institute
1994
567
129
Emma Lundberg (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36823351Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor.Nat Chem Biol2023
37488777Sexually dimorphic effects of monoacylglycerol lipase inhibitor MJN110 on stress-related behaviour and drinking in Marchigian Sardinian alcohol-preferring rats.Br J Pharmacol2023
37488358Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities.Nat Struct Mol Biol2023
37783940Assigning functionality to cysteines by base editing of cancer dependency genes.Nat Chem Biol2023
37878674DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity.Sci Transl Med2023
37084731Proteomic discovery of chemical probes that perturb protein complexes in human cells.Mol Cell2023
37206575Activity-based protein profiling - finding general solutions to specific problems.Isr J Chem2023
37268298Correction to "Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1".J Am Chem Soc2023
37477798Dimethyl fumarate inhibits ZNF217 and can be beneficial in a subset of estrogen receptor positive breast cancers.Breast Cancer Res Treat2023
36782012TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids.Nat Chem Biol2023
36798186Glutathione supports lipid abundance <i>in vivo</i>.bioRxiv2023
36864190Remodeling oncogenic transcriptomes by small molecules targeting NONO.Nat Chem Biol2023
34599873Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling.Cell Chem Biol2022
35510806Broad-range metalloprotease profiling in plants uncovers immunity provided by defence-related metalloenzyme.New Phytol2022
35737950Endocannabinoid dysfunction in neurological disease: neuro-ocular DAGLA-related syndrome.Brain2022
35835746Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension.Nat Commun2022
35788180Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides.Nat Chem Biol2022
35658397LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis.ACS Chem Biol2022
35513432A novel monoacylglycerol lipase-targeted <sup>18</sup>F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network.Acta Pharmacol Sin2022
35483372In situ identification of cellular drug targets in mammalian tissue.Cell2022
36180594Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine.Nat Chem Biol2022
35994671Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain.Proc Natl Acad Sci U S A2022
36170674Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1.J Am Chem Soc2022
36097295Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine.Nat Chem Biol2022
36089535Chemoproteomics-Enabled Identification of 4-Oxo-β-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9.Angew Chem Int Ed Engl2022
35269478Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms.Cells2022
35228727Global profiling of phosphorylation-dependent changes in cysteine reactivity.Nat Methods2022
34705543ABHD6 Controls Amphetamine-Stimulated Hyperlocomotion: Involvement of CB<sub>1</sub> Receptors.Cannabis Cannabinoid Res2022
33398154Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries.Nat Biotechnol2021
33490317Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex.Neurobiol Stress2021
33736974GPR18 drives FAAH inhibition-induced neuroprotection against HIV-1 Tat-induced neurodegeneration.Exp Neurol2021
33899026Multiplexed proteomic profiling of cysteine reactivity and ligandability in human T cells.STAR Protoc2021
33927411ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth.Nat Chem Biol2021
33507883An abundant biliary metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides.J Clin Invest2021
33783207DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras.J Am Chem Soc2021
33636084SPIN4 Is a Principal Endogenous Substrate of the E3 Ubiquitin Ligase DCAF16.Biochemistry2021
33776155Chemical proteomic identification of functional cysteines with atypical electrophile reactivities.Tetrahedron Lett2021
33723037Immunoediting role for major vault protein in apoptotic signaling induced by bacterial <i>N</i>-acyl homoserine lactones.Proc Natl Acad Sci U S A2021
34888501Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function.iScience2021
34764521Refinement of Covalent EGFR Inhibitor AZD9291 to Eliminate Off-target Activity.Tetrahedron Lett2021
34588639Publisher Correction: A proteome-wide atlas of lysine-reactive chemistry.Nat Chem2021
34587978Potentiation of amyloid beta phagocytosis and amelioration of synaptic dysfunction upon FAAH deletion in a mouse model of Alzheimer's disease.J Neuroinflammation2021
34495668CIMAGE2.0: An Expanded Tool for Quantitative Analysis of Activity-Based Protein Profiling (ABPP) Data.J Proteome Res2021
34666187Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation.Bioorg Med Chem Lett2021
34607960Phospholipase Cγ2 regulates endocannabinoid and eicosanoid networks in innate immune cells.Proc Natl Acad Sci U S A2021
34484091Monoacylglycerol Lipase Inhibitor MJN110 Reduces Neuronal Hyperexcitability, Restores Dendritic Arborization Complexity, and Regulates Reward-Related Behavior in Presence of HIV-1 Tat.Front Neurol2021
34569803Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold.J Med Chem2021
34504315A proteome-wide atlas of lysine-reactive chemistry.Nat Chem2021
34221877Development of a highly-specific <sup>18</sup>F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping.Acta Pharm Sin B2021
34056091Functionalized Scout Fragments for Site-Specific Covalent Ligand Discovery and Optimization.ACS Cent Sci2021
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Collaborators

Daniel K Nomura
University of California berkeley
Co-authored papers 25
Alan Saghatelian
Salk Institute for Biological Studies
Co-authored papers 22
Raymond C Stevens
iHuman Institute, ShanghaiTech University
Co-authored papers 12
Gary Siuzdak
Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute
Co-authored papers 10
Stuart L Schreiber
Broad Institute
Co-authored papers 8
Siddhesh S Kamat
Indian Institute of Science Education and Research Pune
Co-authored papers 6
Maurice R Elphick
Queen Mary University of London
Co-authored papers 6
Matthew W Buczynski
Co-authored papers 5
John R Yates
TheScripps Research Institute
Co-authored papers 5
Ian A Wilson
The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 3
Arthur J Olson
Co-authored papers 3
Steven P Gygi
Harvard Medical School
Co-authored papers 3
Luke L Lairson
The Scripps Research Institute
Co-authored papers 3
Laura L Kiessling
Massachusetts Institute of Technology
Co-authored papers 3
Ardem Patapoutian
Howard Hughes Medical Institute
Co-authored papers 3
Ruedi Aebersold
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 2
Oswald Quehenberger
Co-authored papers 2
James C Paulson
Co-authored papers 2
Patrick R Griffin
The Scripps Research Institute
Co-authored papers 2
Jeremy N Rich
UPMC Hillman Cancer Center, University of Pittsburgh Medical Center
Co-authored papers 2
Chuan He
Institute of Hematology, West China Hospital of Sichuan University
Co-authored papers 2
Robert V Farese
Harvard T.H. Chan School of Public Health
Co-authored papers 2
Dong-Hui Chen
University of Washington School of Medicine
Co-authored papers 2
David Baker
University of Washington
Co-authored papers 2
Jon Clardy
Harvard Medical School, Blavatnik Institute
Co-authored papers 2
Frank B Furnari
University of California San Diego
Co-authored papers 2
Carolyn R Bertozzi
Stanford University
Co-authored papers 2
Floyd E Romesberg
Co-authored papers 2
Steven L Gonias
University of California san francisco
Co-authored papers 2
Tobias C Walther
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Release 1.2