Author details

Full Name

Richard J Youle

Affiliation

ORCID

Career Start Year

1976

Papers

263

H Index

104

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37440574	Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage.		2023
36302887	The mechanisms and roles of selective autophagy in mammals.	Nature Reviews Molecular Cell Biology	2023
37873486	STING induces LUBAC-mediated synthesis of linear ubiquitin chains to stimulate innate immune signaling.		2023
37621214	Nix interacts with WIPI2 to induce mitophagy.		2023
36898370	TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.		2023
36394110	Mitochondria and peroxisomes are NIXed for clearance.	EMBO Journal	2022
35395199	Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.	Mol Cell	2022
33208890	Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective.	Cell Death and Differentiation	2021
33891012	VPS13D promotes peroxisome biogenesis.	J Cell Biol	2021
32892694	Two different axes CALCOCO2-RB1CC1 and OPTN-ATG9A initiate PRKN-mediated mitophagy.		2020
33207181	Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.	Mol Cell	2020
33201170	STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain.	Journal of Cell Biology	2020
33029617	Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism.	Brain	2020
32516362	ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer.	J Cell Biol	2020
33021820	Mitochondrial Quality Control and Restraining Innate Immunity.	Annual Review of Cell and Developmental Biology	2020
30714902	Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis.	eLife	2019
31577952	PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis.	Cell Reports	2019
31177092	Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology .	Journal of Biological Chemistry	2019
30853401	Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.	Mol Cell	2019
31416937	Mitochondria-Striking a balance between host and endosymbiont.	Science	2019
30733118	Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.	Molecular Cell	2019
29360040	Endosomal Rab cycles regulate Parkin-mediated mitophagy.	Elife	2018
30452458	Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase Î³.	PLoS Genet	2018
30135585	Parkin and PINK1 mitigate STING-induced inflammation.	Nature	2018
30038392	Active state of Parkin.	Nature Structural and Molecular Biology	2018
29307555	Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance.	Current Biology	2018
29692360	Parkin mediates mitophagy during beige-to-white fat conversion.	Science Signaling	2018
29462587	Mitophagy and Quality Control Mechanisms inÂ Mitochondrial Maintenance.	Current Biology	2018
29325568	PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol.	BMC Biology	2018
28028054	Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins.	EMBO J	2017
28893839	Mitochondrial fission facilitates the selective mitophagy of protein aggregates.	J Cell Biol	2017
26942670	The Mitochondrial Basis of Aging.	Molecular Cell	2016
26887490	Cell biology: Form follows function for mitochondria.	Nature	2016
26923059	Characterization of the membrane-inserted C-terminus of cytoprotective BCL-XL.	Protein Expression and Purification	2016
27126807	Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association.	Circ Res	2016
27035970	Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.	Proc Natl Acad Sci U S A	2016
26240184	MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5.	Journal of Cell Biology	2015
25689131	Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter.	ACS Chem Biol	2015
25611507	The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.	Neuron	2015
25731750	Conformation of BCL-XL upon Membrane Integration.	Journal of Molecular Biology	2015
26182419	Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress.	Neuron	2015
26266977	The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.	Nature	2015
26212327	Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density.	Cell Reports	2015
24569479	Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy.	eLife	2014
24196833	Mutations in Fis1 disrupt orderly disposal of defective mitochondria.	Molecular Biology of the Cell	2014
24721569	Self and nonself: how autophagy targets mitochondria and bacteria.		2014
24751536	PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.	Journal of Cell Biology	2014
23569251	Sequestration and autophagy of mitochondria do not cut proteins across the board.	Proceedings of the National Academy of Sciences of the United States of America	2013
24270810	High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.	Nature	2013
24043775	Atypical mitochondrial fission upon bacterial infection.	Proceedings of the National Academy of Sciences of the United States of America	2013