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Author Details

Eldad Zacksenhaus
University of Toronto
1988
117
34
PMIDPaper TitleJournal TitlePublished Year
36650051A temporal in vivo catalog of chromatin accessibility and expression profiles in pineoblastoma reveals a prevalent role for repressor elements.Genome Res2023
38001575Thinking (Metastasis) outside the (Primary Tumor) Box.Cancers (Basel)2023
37193069FLI1 Regulates Histamine Decarboxylase Expression to Control Inflammation Signaling and Leukemia Progression.J Inflamm Res2023
37016335Lovastatin inhibits erythroleukemia progression through KLF2-mediated suppression of MAPK/ERK signaling.BMC Cancer2023
37463901Distinct shared and compartment-enriched oncogenic networks drive primary versus metastatic breast cancer.Nat Commun2023
37230983CDK4/6 inhibitors and the pRB-E2F1 axis suppress PVR and PD-L1 expression in triple-negative breast cancer.Oncogenesis2023
35104574FLI1 regulates inflammation-associated genes to accelerate leukemogenesis.Cell Signal2022
35412146Current insights into the role of Fli-1 in hematopoiesis and malignant transformation.Cell Mol Life Sci2022
35477769A critical ETV4/Twist1/Vimentin axis in Ha-RAS-induced aggressive breast cancer.Cancer Gene Ther2022
35513042A racemosin B derivative, C25, suppresses breast cancer growth via lysosomal membrane permeabilization and inhibition of autophagic flux.Biochem Pharmacol2022
36586017FLI1 accelerates leukemogenesis through transcriptional regulation of pyruvate kinase-L/R and other glycolytic genes.Med Oncol2022
36335089UM171 cooperates with PIM1 inhibitors to restrict HSC expansion markers and suppress leukemia progression.Cell Death Discov2022
35326742Targeting an MDM2/MYC Axis to Overcome Drug Resistance in Multiple Myeloma.Cancers (Basel)2022
35023164Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.EMBO J2022
33430475Fer and FerT Govern Mitochondrial Susceptibility to Metformin and Hypoxic Stress in Colon and Lung Carcinoma Cells.Cells2021
33911160Inhibition of eEF2K synergizes with glutaminase inhibitors or 4EBP1 depletion to suppress growth of triple-negative breast cancer cells.Sci Rep2021
33717090FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome.Front Immunol2021
33556471Ubash3b promotes TPA-mediated suppression of leukemogenesis through accelerated downregulation of PKCδ protein.Biochimie2021
33578666Progression to Metastasis of Solid Cancer.Cancers (Basel)2021
34475389Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer.Nat Commun2021
34107900ERK activation via A1542/3 limonoids attenuates erythroleukemia through transcriptional stimulation of cholesterol biosynthesis genes.BMC Cancer2021
34134766SMAD1 as a biomarker and potential therapeutic target in drug-resistant multiple myeloma.Biomark Res2021
32220540MARCKS inhibition cooperates with autophagy antagonists to potentiate the effect of standard therapy against drug-resistant multiple myeloma.Cancer Lett2020
32030683Erythropoietin Signaling in the Microenvironment of Tumors and Healthy Tissues.Adv Exp Med Biol2020
31728055Opposing effects of NPM1wt and NPM1c mutants on AKT signaling in AML.Leukemia2020
31894299FLI1 promotes protein translation via the transcriptional regulation of MKNK1 expression.Int J Oncol2020
32064036Stratifying the stratifiers of triple negative breast cancer.Oncotarget2020
33273692A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3.Commun Biol2020
32923545Methylation data of mouse Rb-deficient pineoblastoma.Data Brief2020
32286280Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy.Nat Commun2020
30704524A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling.Breast Cancer Res2019
31836816Molecular stratification within triple-negative breast cancer subtypes.Sci Rep2019
31375085Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity.BMC Cancer2019
30741932Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis.Cell Death Dis2019
28925397Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling.Oncogene2018
30100919Associations Between XPD Lys751Gln Polymorphism and Leukemia: A Meta-Analysis.Front Genet2018
30123416The vulnerability of RB loss in breast cancer: Targeting a void in cell cycle control.Oncotarget2018
30250928CDC25 as a common therapeutic target for triple-negative breast cancer - the challenges ahead.Mol Cell Oncol2018
30387554Novel flavagline-like compounds with potent Fli-1 inhibitory activity suppress diverse types of leukemia.FEBS J2018
30471828Novel racemosin B derivatives as new therapeutic agents for aggressive breast cancer.Bioorg Med Chem2018
30332649Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.Cell Rep2018
29617654Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer.Cell Rep2018
28052010A screen for Fli-1 transcriptional modulators identifies PKC agonists that induce erythroid to megakaryocytic differentiation and suppress leukemogenesis.Oncotarget2017
28215225Transcription Factors in Breast Cancer-Lessons From Recent Genomic Analyses and Therapeutic Implications.Adv Protein Chem Struct Biol2017
29120753Mitochondrial OXPHOS Induced by RB1 Deficiency in Breast Cancer: Implications for Anabolic Metabolism, Stemness, and Metastasis.Trends Cancer2017
28768903microRNA-143/145 loss induces Ras signaling to promote aggressive Pten-deficient basal-like breast cancer.JCI Insight2017
28632792Identification of cell proliferation, immune response and cell migration as critical pathways in a prognostic signature for HER2+:ERα- breast cancer.PLoS One2017
26781438Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer.Breast Cancer Res2016
28005077Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2.Cell Death Dis2016
27571409RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation.J Clin Invest2016
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Collaborators

Zhe Jiang
Toronto General Research Institute, University Health Network, 67 College Street
Co-authored papers 30
Dong-Yu Wang
College of Pharmaceutical Sciences, Shanghai Jiao Tong University
Co-authored papers 12
Brenda L Gallie
The Eye Cancer Clinic, Princess Margaret Cancer Centre, Hospital for Sick Children
Co-authored papers 11
Tao Deng
Co-authored papers 8
Alessandro Datti
University of Perugia
Co-authored papers 7
Gary D Bader
University of Toronto
Co-authored papers 7
James R Woodgett
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 7
Tak W Mak
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 6
Charles M Perou
Co-authored papers 6
Rod Bremner
University of Toronto
Co-authored papers 6
Susan J Done
University Health Network
Co-authored papers 3
Michael D Taylor
The Hospital for Sick Children
Co-authored papers 3
Aaron D Schimmer
Princess Margaret Cancer Centre
Co-authored papers 3
Timothy F Lane
Co-authored papers 3
Deena M A Gendoo
Institute of Cancer and Genomic Sciences, University of Birmingham
Co-authored papers 3
Thomas J Begley
University at Albany
Co-authored papers 2
Karin Przyklenk
Co-authored papers 2
Rima Al-Awar
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 2
Jason E Gestwicki
Institute for Neurodegenerative Diseases, University of California San Francisco
Co-authored papers 2
Svetlana Dokudovskaya
CNRS UMR9018, Institut Gustave Roussy, Universite Paris-Saclay
Co-authored papers 2
Hirotaka Watada
Co-authored papers 2
Sara Cherry
University of Pennsylvania
Co-authored papers 2
Philipp Kapranov
Co-authored papers 2
Carlos L??pez-Ot??n
Instituto Universitario de Oncologia, Universidad de Oviedo
Co-authored papers 2
David Sulzer
New York State Psychiatric Institute, Research Foundation for Mental Hygiene
Co-authored papers 2
David M Sabatini
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
Co-authored papers 2
J. Wade Harper
Harvard Medical School
Co-authored papers 2
Nikolai V Gorbunov
Armed Forces Radiobiology Research Institute
Co-authored papers 2
Juan Fueyo
The University of Texas M.D. Anderson Cancer Center
Co-authored papers 2
Lawrence H Boise
Winship Cancer Institute, Emory University
Co-authored papers 2
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