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Author Details
Full Name
Paul D De Jesus
Affiliation
Sanford Burnham Prebys Medical Discovery Institute
ORCID
Career Start Year
2003
Papers
31
H Index
20
Expertise
CM4AI Collaborator
Trey Ideker (CM4AI)
PMID
Paper Title
Journal Title
Published Year
35766385
Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity.
ACS Infect Dis
2022
33440148
MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells.
Cell Rep
2021
33930332
Functional landscape of SARS-CoV-2 cellular restriction.
Mol Cell
2021
34556855
Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy.
Nat Microbiol
2021
34468177
The Compound SBI-0090799 Inhibits Zika Virus Infection by Blocking <i>De Novo</i> Formation of the Membranous Replication Compartment.
J Virol
2021
34843601
A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor.
PLoS Pathog
2021
32511357
A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals.
bioRxiv
2020
31776276
Viral Determinants in H5N1 Influenza A Virus Enable Productive Infection of HeLa Cells.
J Virol
2020
33024967
Functional Landscape of SARS-CoV-2 Cellular Restriction.
bioRxiv
2020
32707573
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Nature
2020
30397075
SNW1, a Novel Transcriptional Regulator of the NF-κB Pathway.
Mol Cell Biol
2019
30717826
HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses.
Elife
2019
29268608
Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein.
ACS Infect Dis
2018
29490283
Large-Scale Arrayed Analysis of Protein Degradation Reveals Cellular Targets for HIV-1 Vpu.
Cell Rep
2018
28248290
Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation.
Nat Microbiol
2017
25984567
A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein.
ACS Infect Dis
2015
26651948
Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.
Cell Host Microbe
2015
26046437
PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.
Cell
2015
24586659
Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ.
PLoS One
2014
24807708
RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production.
J Virol
2014
22423970
Cofactors required for TLR7- and TLR9-dependent innate immune responses.
Cell Host Microbe
2012
21949408
Tumor suppressor protein (p)53, is a regulator of NF-kappaB repression by the glucocorticoid receptor.
Proc Natl Acad Sci U S A
2011
20027183
Human host factors required for influenza virus replication.
Nature
2010
20622870
Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression.
Nat Cell Biol
2010
18302737
Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cells.
Genome Biol
2008
18854154
Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.
Cell
2008
17828270
A probability-based approach for the analysis of large-scale RNAi screens.
Nat Methods
2007
17939994
A role for IkappaB kinase 2 in bipolar spindle assembly.
Proc Natl Acad Sci U S A
2007
16474387
A functional genomics approach to the mode of action of apratoxin A.
Nat Chem Biol
2006
14990790
Identification of p53 regulators by genome-wide functional analysis.
Proc Natl Acad Sci U S A
2004
14514886
Genome-scale functional profiling of the mammalian AP-1 signaling pathway.
Proc Natl Acad Sci U S A
2003
1 - 31 of 31
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