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Author Details

Susmita Kaushik
Albert Einstein College of Medicine
2003
62
47
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38039131NGLY1 mutations cause protein aggregation in human neurons.Cell Rep2023
37831778A noncanonical function of SKP1 regulates the switch between autophagy and unconventional secretion.Sci Adv2023
35167431Circadian remodeling of the proteome by chaperone-mediated autophagy.Autophagy2022
35363568Protective role of chaperone-mediated autophagy against atherosclerosis.Proc Natl Acad Sci U S A2022
36383673Chaperone-mediated autophagy regulates adipocyte differentiation.Sci Adv2022
33442062Chaperone-mediated autophagy sustains haematopoietic stem-cell function.Nature2021
33891876Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.Cell2021
34876687Reciprocal regulation of chaperone-mediated autophagy and the circadian clock.Nat Cell Biol2021
34563704Autophagy and the hallmarks of aging.Ageing Res Rev2021
31504266Comprehensive autophagy evaluation in cardiac disease models.Cardiovasc Res2020
30918111A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.Sci Transl Med2019
31412041(-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells.PLoS One2019
29301854Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100.Circ Res2018
30202070Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD.Nat Commun2018
29626215The coming of age of chaperone-mediated autophagy.Nat Rev Mol Cell Biol2018
26902588AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA.Autophagy2016
27304509Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.Cell Metab2016
27405763Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy.J Biol Chem2016
26799652Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy2016
25961502Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis.Nat Cell Biol2015
26646497Proteostasis and aging.Nat Med2015
22331875Inhibitory effect of dietary lipids on chaperone-mediated autophagy.Proc Natl Acad Sci U S A2012
22966490Guidelines for the use and interpretation of assays for monitoring autophagy.Autophagy2012
23059540Chaperones in autophagy.Pharmacol Res2012
22748206Chaperone-mediated autophagy: a unique way to enter the lysosome world.Trends Cell Biol2012
22840404Age-related oxidative stress compromises endosomal proteostasis.Cell Rep2012
22249165Loss of autophagy in hypothalamic POMC neurons impairs lipolysis.EMBO Rep2012
20152936Protein homeostasis and aging: The importance of exquisite quality control.Ageing Res Rev2011
22171050Constitutive upregulation of chaperone-mediated autophagy in Huntington's disease.J Neurosci2011
21803288Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance.Cell Metab2011
21464620Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.Autophagy2011
21238931Microautophagy of cytosolic proteins by late endosomes.Dev Cell2011
21186265Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.Brain2011
21282471Chaperone-mediated autophagy at a glance.J Cell Sci2011
20075865HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy.EMBO J2010
20797626Identification of regulators of chaperone-mediated autophagy.Mol Cell2010
21029294Autophagic pathways and metabolic stress.Diabetes Obes Metab2010
20529957Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.Hum Mol Genet2010
20647740Inhibitory effect of intracellular lipid load on macroautophagy.Autophagy2010
20383138Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.Nat Neurosci2010
20375270Altered lipid content inhibits autophagic vesicular fusion.FASEB J2010
20026095Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats.Toxicol Appl Pharmacol2010
20023429Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation.Autophagy2010
19200890Methods to monitor chaperone-mediated autophagy.Methods Enzymol2009
19654187Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing.Hum Mol Genet2009
19339967Autophagy regulates lipid metabolism.Nature2009
19411822In search of an "autophagomometer".Autophagy2009
18172548Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy.J Clin Invest2008
18644871The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane.Mol Cell Biol2008
18337468Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy.Mol Biol Cell2008
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Collaborators

Albert Einstein College of Medicine
Co-authored papers 54
New York State Psychiatric Institute, Research Foundation for Mental Hygiene
Co-authored papers 6
Weill Cornell School of Medicine
Co-authored papers 6
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Co-authored papers 5
Albert Einstein College of Medicine, USA Institute for Aging Studies
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Englander Institute for Precision Medicine
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Co-authored papers 4
Albert Einstein College of Medicine
Co-authored papers 4
Institute for Neurodegenerative Diseases, University of California San Francisco
Co-authored papers 3
University College London, UK Dementia Research Institute
Co-authored papers 3
Albert Einstein College of Medicine
Co-authored papers 3
CRUK MRC Oxford Institute for Radiation Oncology, University of Oxford
Co-authored papers 3
University of the Basque Country (UPV/EHU)
Co-authored papers 3
University at Albany
Co-authored papers 2
Universite de Montreal
Co-authored papers 2
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 2
University of California San Diego
Co-authored papers 2
University of Warwick
Co-authored papers 2
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Co-authored papers 2
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CNRS UMR9018, Institut Gustave Roussy, Universite Paris-Saclay
Co-authored papers 2
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University of Pennsylvania
Co-authored papers 2
Instituto Universitario de Oncologia, Universidad de Oviedo
Co-authored papers 2
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
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Harvard Medical School
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Armed Forces Radiobiology Research Institute
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The University of Texas M.D. Anderson Cancer Center
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Winship Cancer Institute, Emory University
Co-authored papers 2