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Author Details

Michael A Carpenter
University of Minnesota
2006
39
20
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36923917APOBEC3A Catalytic Inactivity Mutation Induces Tertiary Structure Destabilization.ACS Med Chem Lett2023
37555667APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1.mBio2023
37735199APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer.Nat Genet2023
38033156Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer.PLoS Genet2023
37034786APOBEC3 degradation is the primary function of HIV-1 Vif for virus replication in the myeloid cell line THP-1.bioRxiv2023
37298259DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo.Int J Mol Sci2023
35272863The current toolbox for APOBEC drug discovery.Trends Pharmacol Sci2022
35476445Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.Sci Adv2022
33658373Structural basis for recognition of distinct deaminated DNA lesions by endonuclease Q.Proc Natl Acad Sci U S A2021
33921405Structural Characterization of a Minimal Antibody against Human APOBEC3B.Viruses2021
32985974Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B.Elife2020
30420783Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity.Nat Microbiol2019
32123856Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B.FASEB Bioadv2019
30130104Determinants of Oligonucleotide Selectivity of APOBEC3B.J Chem Inf Model2019
31544853A Rabbit Monoclonal Antibody against the Antiviral and Cancer Genomic DNA Mutating Enzyme APOBEC3B.Antibodies (Basel)2019
31145054HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1.J Gen Virol2019
30578845A lentivirus-based system for Cas9/gRNA expression and subsequent removal by Cre-mediated recombination.Methods2019
29290613The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.Mol Cell2018
30297863Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease.Nat Commun2018
29234087Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.Sci Rep2017
27163364Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B.PLoS One2016
27650891The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.Nat Commun2016
26416889Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain.J Biol Chem2015
26491161A Naturally Occurring Domestic Cat APOBEC3 Variant Confers Resistance to Feline Immunodeficiency Virus Infection.J Virol2015
26358009Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries.J Med Chem2015
24361275APOBEC3 multimerization correlates with HIV-1 packaging and restriction activity in living cells.J Mol Biol2014
23389445APOBEC3B is an enzymatic source of mutation in breast cancer.Nature2013
24154874APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.Cancer Res2013
23938202The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.J Mol Biol2013
23685212Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain.Structure2013
23640892Endogenous APOBEC3A DNA cytosine deaminase is cytoplasmic and nongenotoxic.J Biol Chem2013
22181350First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.ACS Chem Biol2012
22896697Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A.J Biol Chem2012
20338830Determinants of sequence-specificity within human AID and APOBEC3G.DNA Repair (Amst)2010
18187371Is AID a monomer in solution?DNA Repair (Amst)2008
18718929DNA base flipping by both members of the PspGI restriction-modification system.Nucleic Acids Res2008
18829716Central base pair flipping and discrimination by PspGI.Nucleic Acids Res2008
16464021Evaluation of molecular models for the affinity maturation of antibodies: roles of cytosine deamination by AID and DNA repair.Chem Rev2006
16893959Sequence-dependent enhancement of hydrolytic deamination of cytosines in DNA by the restriction enzyme PspGI.Nucleic Acids Res2006
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Collaborators

Reuben S Harris
University of Texas Health San Antonio
Co-authored papers 32
William L Brown
University of Minnesota
Co-authored papers 17
Daniel A Harki
University of Minnesota
Co-authored papers 7
Anurag Rathore
Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center
Co-authored papers 7
Rommie E Amaro
University of California
Co-authored papers 5
Ming Li
Department of Cancer Research Institute, University of South Australia
Co-authored papers 5
Shivender M D Shandilya
University of Massachusetts Medical School
Co-authored papers 3
Celia A Schiffer
University of Massachusetts Chan Medical School
Co-authored papers 3
Mohan Somasundaran
University of Massachusetts Chan Medical School
Co-authored papers 2
Jeffrey R Wagner
Kaiser Permanente San Francisco Medical Center
Co-authored papers 2
Markus-Frederik Bohn
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 2
Brett D Anderson
University of Minnesota
Co-authored papers 2
Angela L Perkins
University of Minnesota
Co-authored papers 2
Ludmil B Alexandrov
Moores Cancer Center, university of california san diego
Co-authored papers 1
John S Albin
Massachusetts General Hospital
Co-authored papers 1
Kei Sato
The Institute of Medical Science, The University of Tokyo
Co-authored papers 1
Jeffrey R Johnson
Gladstone Institutes
Co-authored papers 1
Derek J Hook
Institute for Therapeutics Discovery and Development, University of Minnesota
Co-authored papers 1
Hugues Sicotte
Mayo Clinic
Co-authored papers 1
Ellen L Goode
Mayo Clinic College of Medicine
Co-authored papers 1
Sean Humphray
Illumina Ltd.
Co-authored papers 1
Linda Chelico
University of Saskatchewan, College of Medicine
Co-authored papers 1
Marina Bibikova
Departments of Bioinformatics and Clinical Genomics, Illumina Inc.
Co-authored papers 1
Ann L Oberg
Co-authored papers 1
Michael A Parniak
University of Pittsburgh School of Medicine
Co-authored papers 1
David A Largaespada
University of Minnesota
Co-authored papers 1
David R Bentley
Illumina Cambridge Ltd.
Co-authored papers 1
Jack F Greenblatt
College Street, University of Toronto
Co-authored papers 1
Krishan K Pandey
Saint Louis University
Co-authored papers 1
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Release 1.2