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Author Details
Full Name
Vardhman K Rakyan
Affiliation
The Blizard Institute, Queen Mary University of London
ORCID
Career Start Year
2000
Papers
63
H Index
42
Expertise
CM4AI Collaborator
Trey Ideker (CM4AI)
PMID
Paper Title
Journal Title
Published Year
37436062
Hemin availability induces coordinated DNA methylation and gene expression changes in <i>Porphyromonas gingivalis</i>.
mSystems
2023
34818986
An integrative epi-transcriptomic approach identifies the human cartilage chitinase 3-like protein 2 (<i>CHI3L2)</i> as a potential mediator of B12 deficiency in adipocytes.
Epigenetics
2022
36097184
A stochastic basis for metabolic phenotypes.
Nat Metab
2022
35164830
Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states.
Genome Biol
2022
34675201
Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma.
Nat Commun
2021
32126024
DNA methylation clocks as a predictor for ageing and age estimation in naked mole-rats, <i>Heterocephalus glaber</i>.
Aging (Albany NY)
2020
33048947
The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations.
PLoS Genet
2020
30462145
BulkVis: a graphical viewer for Oxford nanopore bulk FAST5 files.
Bioinformatics
2019
31767039
DNA methylation aging clocks: challenges and recommendations.
Genome Biol
2019
28836271
Roadmap for investigating epigenome deregulation and environmental origins of cancer.
Int J Cancer
2018
29412141
Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci.
Elife
2018
29720174
Early life diet conditions the molecular response to post-weaning protein restriction in the mouse.
BMC Biol
2018
29452591
Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species.
Genome Biol
2018
28833606
DNA methylation profiles between airway epithelium and proxy tissues in children.
Acta Paediatr
2017
27386920
Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice.
Science
2016
26376367
Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease.
Mucosal Immunol
2016
27851974
eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data.
Cell Rep
2016
27898055
Increased DNA methylation variability in type 1 diabetes across three immune effector cell types.
Nat Commun
2016
27716309
Correlation of an epigenetic mitotic clock with cancer risk.
Genome Biol
2016
25496377
Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates.
Epigenetics
2015
26381124
The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.
Genome Biol
2015
26669438
A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation.
Genome Med
2015
25888192
Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development.
BMC Genomics
2015
25634562
Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring.
Hum Mol Genet
2015
25634226
The human blood DNA methylome displays a highly distinctive profile compared with other somatic tissues.
Epigenetics
2015
25031617
Correcting for cell-type composition bias in epigenome-wide association studies.
Genome Med
2014
23538714
Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies.
Epigenetics
2013
24330312
Marmal-aid--a database for Infinium HumanMethylation450.
BMC Bioinformatics
2013
24071862
Integrated analysis of genome-wide genetic and epigenetic association data for identification of disease mechanisms.
Epigenetics
2013
23880534
The promise and challenges of blood spot methylomics.
Epigenetics
2013
23697936
Transgenerational inheritance of non-genetically determined phenotypes.
Biochem Soc Trans
2013
23706135
Inactive or moderately active human promoters are enriched for inter-individual epialleles.
Genome Biol
2013
22398613
BLUEPRINT to decode the epigenetic signature written in blood.
Nat Biotechnol
2012
22919074
Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans.
Genome Res
2012
22826509
A functional methylome map of ulcerative colitis.
Genome Res
2012
22902559
Protection against de novo methylation is instrumental in maintaining parent-of-origin methylation inherited from the gametes.
Mol Cell
2012
22479372
Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats.
PLoS One
2012
20839222
The hunt for the epiallele.
Environ Mol Mutagen
2011
21940836
Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates.
Genome Res
2011
21980303
Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.
PLoS Genet
2011
21747404
Epigenome-wide association studies for common human diseases.
Nat Rev Genet
2011
21324880
Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors.
Genome Res
2011
20071334
DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta.
J Biol Chem
2010
21124985
Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.
PLoS One
2010
20687937
Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus.
BMC Med Genomics
2010
20219945
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains.
Genome Res
2010
19237542
Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface.
J Biol Chem
2009
19349366
Sites of differential DNA methylation between placenta and peripheral blood: molecular markers for noninvasive prenatal diagnosis of aneuploidies.
Am J Pathol
2009
18325624
The methylome: approaches for global DNA methylation profiling.
Trends Genet
2008
18849521
Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex.
Genome Res
2008
1 - 50 of 63
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