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Author Details

Vardhman K Rakyan
The Blizard Institute, Queen Mary University of London
2000
63
42
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37436062Hemin availability induces coordinated DNA methylation and gene expression changes in <i>Porphyromonas gingivalis</i>.mSystems2023
34818986An integrative epi-transcriptomic approach identifies the human cartilage chitinase 3-like protein 2 (<i>CHI3L2)</i> as a potential mediator of B12 deficiency in adipocytes.Epigenetics2022
36097184A stochastic basis for metabolic phenotypes.Nat Metab2022
35164830Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states.Genome Biol2022
34675201Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma.Nat Commun2021
32126024DNA methylation clocks as a predictor for ageing and age estimation in naked mole-rats, <i>Heterocephalus glaber</i>.Aging (Albany NY)2020
33048947The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations.PLoS Genet2020
30462145BulkVis: a graphical viewer for Oxford nanopore bulk FAST5 files.Bioinformatics2019
31767039DNA methylation aging clocks: challenges and recommendations.Genome Biol2019
28836271Roadmap for investigating epigenome deregulation and environmental origins of cancer.Int J Cancer2018
29412141Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci.Elife2018
29720174Early life diet conditions the molecular response to post-weaning protein restriction in the mouse.BMC Biol2018
29452591Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species.Genome Biol2018
28833606DNA methylation profiles between airway epithelium and proxy tissues in children.Acta Paediatr2017
27386920Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice.Science2016
26376367Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease.Mucosal Immunol2016
27851974eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data.Cell Rep2016
27898055Increased DNA methylation variability in type 1 diabetes across three immune effector cell types.Nat Commun2016
27716309Correlation of an epigenetic mitotic clock with cancer risk.Genome Biol2016
25496377Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates.Epigenetics2015
26381124The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.Genome Biol2015
26669438A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation.Genome Med2015
25888192Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development.BMC Genomics2015
25634562Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring.Hum Mol Genet2015
25634226The human blood DNA methylome displays a highly distinctive profile compared with other somatic tissues.Epigenetics2015
25031617Correcting for cell-type composition bias in epigenome-wide association studies.Genome Med2014
23538714Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies.Epigenetics2013
24330312Marmal-aid--a database for Infinium HumanMethylation450.BMC Bioinformatics2013
24071862Integrated analysis of genome-wide genetic and epigenetic association data for identification of disease mechanisms.Epigenetics2013
23880534The promise and challenges of blood spot methylomics.Epigenetics2013
23697936Transgenerational inheritance of non-genetically determined phenotypes.Biochem Soc Trans2013
23706135Inactive or moderately active human promoters are enriched for inter-individual epialleles.Genome Biol2013
22398613BLUEPRINT to decode the epigenetic signature written in blood.Nat Biotechnol2012
22919074Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans.Genome Res2012
22826509A functional methylome map of ulcerative colitis.Genome Res2012
22902559Protection against de novo methylation is instrumental in maintaining parent-of-origin methylation inherited from the gametes.Mol Cell2012
22479372Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats.PLoS One2012
20839222The hunt for the epiallele.Environ Mol Mutagen2011
21940836Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates.Genome Res2011
21980303Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.PLoS Genet2011
21747404Epigenome-wide association studies for common human diseases.Nat Rev Genet2011
21324880Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors.Genome Res2011
20071334DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta.J Biol Chem2010
21124985Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.PLoS One2010
20687937Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus.BMC Med Genomics2010
20219945Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains.Genome Res2010
19237542Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface.J Biol Chem2009
19349366Sites of differential DNA methylation between placenta and peripheral blood: molecular markers for noninvasive prenatal diagnosis of aneuploidies.Am J Pathol2009
18325624The methylome: approaches for global DNA methylation profiling.Trends Genet2008
18849521Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex.Genome Res2008
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Collaborators

UCL Cancer Institute, University College London
Co-authored papers 26
The Blizard Institute Queen Mary University of London London UK.
Co-authored papers 19
Co-authored papers 16
UCL Cancer Institute, University College London
Co-authored papers 9
Blizard Institute, Barts and Royal London Medical School
Co-authored papers 7
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Co-authored papers 6
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Co-authored papers 5
St. Anna Children's Cancer Research Institute (CCRI)
Co-authored papers 4
European Bioinformatics Institute
Co-authored papers 4
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Blizard Institute, Queen Mary University of London
Co-authored papers 4
Co-authored papers 4
European Bioinformatics Institute
Co-authored papers 3
Spain Universitat de Barcelona (UB)
Co-authored papers 3
University of Cambridge
Co-authored papers 3
Center for Omics Sciences, IRCCS San Raffaele Scientific Institute
Co-authored papers 2
Co-authored papers 2
University of Essex
Co-authored papers 2
Fels Cancer Institute for Personalized Medicine, Temple University School of Medicine
Co-authored papers 2
Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 2
The Babraham Institute
Co-authored papers 2
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Heart and Lung Research Institute, University of Cambridge
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Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University
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Wellcome Sanger Institute
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Irving Institute for Cancer Dynamics, Columbia University
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William Harvey Research Institute, Queen Mary University of London
Co-authored papers 2