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Author Details

Victor R DeFilippis
Vaccine and Gene Therapy Institute, Oregon Health and Science University
2000
60
30
PMIDPaper TitleJournal TitlePublished Year
37983245Mayaro virus pathogenesis and immunity in rhesus macaques.PLoS Negl Trop Dis2023
31338593Chikungunya Virus Vaccines: Platforms, Progress, and Challenges.Curr Top Microbiol Immunol2022
35471821Identification and Characterization of Small-Molecule IRF3-Dependent Immune Activators for Pharmaceutical Development.ACS Chem Biol2022
35788221Development of a next-generation chikungunya virus vaccine based on the HydroVax platform.PLoS Pathog2022
35849213Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists.Geroscience2022
34152810Identification of Quinolinones as Antivirals against Venezuelan Equine Encephalitis Virus.Antimicrob Agents Chemother2021
33793555Non-replicating adenovirus based Mayaro virus vaccine elicits protective immune responses and cross protects against other alphaviruses.PLoS Negl Trop Dis2021
33835811Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors.J Med Chem2021
34411201Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferons.PLoS Pathog2021
32117091The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection.Front Microbiol2020
32101570Herpes simplex virus type 1 inflammasome activation in proinflammatory human macrophages is dependent on NLRP3, ASC, and caspase-1.PLoS One2020
32733475Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner.Front Immunol2020
30755509Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome.mBio2019
31736977Vaccine-Induced Skewing of T Cell Responses Protects Against Chikungunya Virus Disease.Front Immunol2019
31257853Studies on Dibenzylamines as Inhibitors of Venezuelan Equine Encephalitis Virus.ACS Infect Dis2019
30917980Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs.Antimicrob Agents Chemother2019
31060350Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist.ACS Infect Dis2019
29263267Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway.J Virol2018
29343712Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology.Nat Commun2018
28808971High-Throughput Screening for Identification of Novel Innate Immune Activators.Methods Mol Biol2017
28278237Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.PLoS Pathog2017
28380070Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.PLoS Pathog2017
28465426A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses.mBio2017
27874833A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression.Elife2016
27736984Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus.PLoS Pathog2016
25973608Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms.PLoS Pathog2015
26646986Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.PLoS Pathog2015
26085158The ORF61 Protein Encoded by Simian Varicella Virus and Varicella-Zoster Virus Inhibits NF-κB Signaling by Interfering with IκBα Degradation.J Virol2015
26018150Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists.J Virol2015
25955717Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway.PLoS Pathog2015
24691437Cytomegalovirus pp65 limits dissemination but is dispensable for persistence.J Clin Invest2014
24013068The tiers and dimensions of evasion of the type I interferon response by human cytomegalovirus.J Mol Biol2013
24955107The inflammasome as a target of modulation by DNA viruses.Future Virol2013
23936572Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunity.PLoS Negl Trop Dis2013
22171275Viral interferon regulatory factors are critical for delay of the host immune response against rhesus macaque rhadinovirus infection.J Virol2012
22749601Motif-optimized subtype A HIV envelope-based DNA vaccines rapidly elicit neutralizing antibodies when delivered sequentially.Vaccine2012
22396129Association of human papillomavirus type 31 variants with risk of cervical intraepithelial neoplasia grades 2-3.Int J Cancer2012
20962078Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoff.J Virol2011
22028943Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression.PLoS Negl Trop Dis2011
20930069IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin.Blood2011
19846511Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1.J Virol2010
20699190Viral hijacking of the host ubiquitin system to evade interferon responses.Curr Opin Microbiol2010
20573816Activation of the interferon response by human cytomegalovirus occurs via cytoplasmic double-stranded DNA but not glycoprotein B.J Virol2010
19229316Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility.PLoS Pathog2009
18093265The role of angiogenic and wound repair factors during CMV-accelerated transplant vascular sclerosis in rat cardiac transplants.Am J Transplant2008
18637515Cytomegalovirus immune evasion.Curr Top Microbiol Immunol2008
17251289Rat cytomegalovirus gene expression in cardiac allograft recipients is tissue specific and does not parallel the profiles detected in vitro.J Virol2007
17892221Induction and evasion of the type I interferon response by cytomegaloviruses.Adv Exp Med Biol2007
17686866West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis.J Virol2007
17001305The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma.Oncogene2007
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Collaborators

Daniel N Streblow
Vaccine and Gene Therapy Institute, Oregon Health and Science University
Co-authored papers 25
Craig N Kreklywich
Vaccine and Gene Therapy Institute, Oregon Health and Science University
Co-authored papers 14
Jay A Nelson
Oregon Health and Science University
Co-authored papers 11
Alec J Hirsch
Vaccine & Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 8
Michael Denton
Vaccine and Gene Therapy Institute, Oregon Health and Science University
Co-authored papers 7
Thomas E Morrison
University of Colorado Anschutz Medical Campus
Co-authored papers 7
Mark T Heise
University of North Carolina at Chapel Hill.
Co-authored papers 7
Jessica L Smith
Vaccine and Gene Therapy Institute, Oregon Health and Science University
Co-authored papers 7
Jinu Abraham
Oregon Health & Science University
Co-authored papers 5
Janko Nikolich-Zugich
University of Arizona Center on Aging, University of Arizona
Co-authored papers 3
Byung Park
Oregon Health & Science University
Co-authored papers 2
Michael J Gough
Earle A. Chiles Research Institute, Providence Cancer Institute
Co-authored papers 2
Heather L Meyers
Co-authored papers 2
Igor Landais
Vaccine and Gene Therapy Institute, Oregon Health and Sciences University
Co-authored papers 2
Richard D Smith
Pacific Northwest National Laboratory
Co-authored papers 1
Joseph L DeRisi
University of California San Francisco
Co-authored papers 1
Patrizia Caposio
Vaccine and Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 1
Ernesto S Nakayasu
Co-authored papers 1
Ted M Ross
Center for Vaccines and Immunology, University of Georgia
Co-authored papers 1
Xuexiang Zhang
Baruch S. Blumberg Institute
Co-authored papers 1
Meaghan H Hancock
Vaccine and Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 1
Leonidas Stamatatos
Co-authored papers 1
Robert P Searles
Oregon Health & Science University
Co-authored papers 1
Louis J Picker
Vaccine and Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 1
J??rgen Haas
University of Edinburgh
Co-authored papers 1
Shannon K McWeeney
Oregon Health & Science University, University of California Berkeley
Co-authored papers 1
Finn Grey
The Roslin Institute, The University of Edinburgh
Co-authored papers 1
Giselle M Knudsen
Department of Pharmaceutical Chemistry, University of California san francisco
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Clayton R Morrison
University of North Carolina School of Medicine
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Release 1.2