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Author Details

Mark R Denison
Vanderbilt University Medical Center
1982
130
56
PMIDPaper TitleJournal TitlePublished Year
36697369Positive-strand RNA viruses-a Keystone Symposia report.Ann N Y Acad Sci2023
37800975Evaluation of <i>in vitro</i> antiviral activity of SARS-CoV-2 M<sup>pro</sup> inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions.Antimicrob Agents Chemother2023
37338298A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance.mBio2023
34901783Standardized two-step testing of antibody activity in COVID-19 convalescent plasma.iScience2022
35780813Neutralizing COVID-19 Convalescent Plasma in Adults Hospitalized With COVID-19: A Blinded, Randomized, Placebo-Controlled Trial.Chest2022
35482820Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.Sci Transl Med2022
35924922Proteolytic Processing of the Coronavirus Replicase Nonstructural Protein 14 Exonuclease Is Not Required for Virus Replication but Alters RNA Synthesis and Viral Fitness.J Virol2022
35301523Integrating SARS-CoV-2 Antibody Results in Children Into Pandemic Response.Pediatrics2022
32918548Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2.J Pediatric Infect Dis Soc2021
33743799Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults.Trials2021
33688640Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults.Res Sq2021
34710354Stabilized coronavirus spike stem elicits a broadly protective antibody.Cell Rep2021
34111271Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit.J Infect Dis2021
33465137The coronavirus proofreading exoribonuclease mediates extensive viral recombination.PLoS Pathog2021
33472930Reovirus RNA recombination is sequence directed and generates internally deleted defective genome segments during passage.J Virol2021
33270381Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination.N Engl J Med2021
32253226An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.Sci Transl Med2020
31924756Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.Nat Commun2020
32663912An mRNA Vaccine against SARS-CoV-2 - Preliminary Report.N Engl J Med2020
32577634SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness.bioRxiv2020
32991794Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults.N Engl J Med2020
32756549SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness.Nature2020
32668216Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice.Cell Rep2020
32318706Multicenter Initial Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2.J Pediatric Infect Dis Soc2020
32511392Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.bioRxiv2020
31125806Nucleoside analogues for the treatment of coronavirus infections.Curr Opin Virol2019
31553909Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD.Cell Rep2019
31578288Small-Molecule Antiviral β-d-N[4]-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance.J Virol2019
31233808Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase.Antiviral Res2019
31341046Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus.J Virol2019
29511076Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.mBio2018
29717007Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses.mBio2018
29514901Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape.J Virol2018
28659436Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.Sci Transl Med2017
28177862Middle East Respiratory Syndrome.N Engl J Med2017
28143984In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins.mBio2017
29046453Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity.J Virol2017
29114026Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations.mBio2017
28807998Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.Proc Natl Acad Sci U S A2017
27279608Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens.J Virol2016
27535047Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses.J Virol2016
27252528Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity.J Virol2016
25301210Novel poxvirus infection in 2 patients from the United States.Clin Infect Dis2015
26055715Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.J Biol Chem2015
26218507Evaluation of candidate vaccine approaches for MERS-CoV.Nat Commun2015
26109733Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry.J Virol2015
25855750Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity.J Virol2015
25473044Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications.J Virol2015
24253287Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses.J Infect Dis2014
26958717Thinking Outside the Triangle: Replication Fidelity of the Largest RNA Viruses.Annu Rev Virol2014
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Collaborators

Ralph S Baric
University of North Carolina
Co-authored papers 33
Rachel L Graham
University of North Carolina
Co-authored papers 24
Amy C Sims
The University of North Carolina at Chapel Hill
Co-authored papers 21
James D Chappell
Vanderbilt University Medical Center
Co-authored papers 20
Laura J Stevens
Vanderbilt University Medical Center
Co-authored papers 13
Boyd L Yount
University of North Carolina at Chapel Hill
Co-authored papers 9
Sarah R Leist
University of North Carolina at Chapel Hill
Co-authored papers 8
Alexandra Sch??fer
University of North Carolina at Chapel Hill
Co-authored papers 8
Eric F Donaldson
Co-authored papers 7
John R Mascola
Co-authored papers 6
Jason S McLellan
Co-authored papers 6
Lingshu Wang
National Institute of Allergy and Infectious Disease, National Institute of Health
Co-authored papers 6
Nicole A Doria-Rose
Co-authored papers 5
Stephen D Schmidt
Co-authored papers 5
Jill M Pulley
Vanderbilt University School of Medicine
Co-authored papers 4
Wesley H Self
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Gordon R Bernard
Vanderbilt University
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Kevin W Graepel
Washington University of Medicine
Co-authored papers 4
Isaac P Thomsen
Vanderbilt University Medical Center
Co-authored papers 4
Marco Vignuzzi
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 4
Allison P Wheeler
Vanderbilt University Medical Center
Co-authored papers 4
Todd W Rice
Vanderbilt University Medical Center
Co-authored papers 4
Hollis R O'Neal
LSU Health Sciences Center/Our Lady of the Lake Regional Medical Center
Co-authored papers 3
Sakshi Tomar
J. David Gladstone Institutes
Co-authored papers 3
Christopher J Lindsell
Duke University
Co-authored papers 3
Claudia S Cohn
University of Minnesota
Co-authored papers 3
Adit A Ginde
University of Colorado School of Medicine
Co-authored papers 3
Vince D Cataldo
Louisiana State University Health Sciences Center.
Co-authored papers 3
Alan E Jones
University of Mississippi Medical Center
Co-authored papers 3
Ande West
University of North Carolina at Chapel Hill
Co-authored papers 3
Release 1.2