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Author Details

Stephen J Elledge
Howard Hughes Medical Institute, Brigham and Women's Hospital, Harvard Medical School
1982
376
154
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36593401High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform.Nat Biotechnol2023
38016469TScan-II: A genome-scale platform for the de novo identification of CD4<sup>+</sup> T cell epitopes.Cell2023
37616343The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.Science2023
37738965Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping.Mol Cell2023
37735597Defining E3 ligase-substrate relationships through multiplex CRISPR screening.Nat Cell Biol2023
37577562Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn.bioRxiv2023
37731906Parasitic, bacterial, viral, immune-mediated, metabolic and nutritional factors associated with nodding syndrome.Brain Commun2023
37977122Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping.Mol Cell2023
37494473Signatures of AAV-2 immunity are enriched in children with severe acute hepatitis of unknown etiology.Sci Transl Med2023
37201526Ubiquitin-independent proteasomal degradation driven by C-degron pathways.Mol Cell2023
37061980An Editor's rave review.Genes Dev2023
36608670A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.Mol Cell2023
36805027E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.Mol Cell2023
35017504A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells.Nat Commun2022
36313802CasPlay provides a gRNA-barcoded CRISPR-based display platform for antibody repertoire profiling.Cell Rep Methods2022
35937932VirScan: High-throughput Profiling of Antiviral Antibody Epitopes.Bio Protoc2022
35992305Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization.iScience2022
33907750Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo.bioRxiv2022
35042811V-CARMA: A tool for the detection and modification of antigen-specific T cells.Proc Natl Acad Sci U S A2022
35013224Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation.Nat Commun2022
35149558Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1.Proc Natl Acad Sci U S A2022
35148840An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.Cell2022
35025605Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis.Science2022
33414220Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction.Science2021
33827988ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.Proc Natl Acad Sci U S A2021
33571169Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality.J Clin Invest2021
33567269Systematic characterization of mutations altering protein degradation in human cancers.Mol Cell2021
33707234CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells.Cancer Discov2021
33723254SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication.Nat Commun2021
33915088Coordinate regulation of the senescent state by selective autophagy.Dev Cell2021
33831416The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination.J Biol Chem2021
34529489The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation.Science2021
34755130High-resolution epitope mapping by AllerScan reveals relationships between IgE and IgG repertoires during peanut oral immunotherapy.Cell Rep Med2021
34390675CRISPR-based peptide library display and programmable microarray self-assembly for rapid quantitative protein binding assays.Mol Cell2021
34597596The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.Mol Cell2021
34711655Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.Genes Dev2021
32386318High-Throughput Screening of Kawasaki Disease Sera for Antiviral Antibodies.J Infect Dis2020
32041867The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning.Proc Natl Acad Sci U S A2020
33186527Some Like It Sweet: Dendritic Cells Add Sugar to Their T(ea).Cell2020
33354688Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality.medRxiv2020
32243838A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers.Cancer Cell2020
30686591Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.Mol Cell2019
31723608Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy.Sci Adv2019
31186276Comprehensive viromewide antibody responses by systematic epitope scanning after hematopoietic cell transplantation.Blood2019
31358949Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists.Nat Ecol Evol2019
31553912Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.Cell Rep2019
31494268Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions.Genomics Proteomics Bioinformatics2019
31262815Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells.Proc Natl Acad Sci U S A2019
31398327T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes.Cell2019
31042470Comprehensive Profiling of HIV Antibody Evolution.Cell Rep2019
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Collaborators

J. Wade Harper
Harvard Medical School
Co-authored papers 58
Steven P Gygi
Harvard Medical School
Co-authored papers 15
Agata Smogorzewska
Instituto de Investigacion Sanitaria Hospital 12 de Octubre (imas12)
Co-authored papers 14
Gregory J Hannon
Co-authored papers 14
Ronald W Davis
Stanford University
Co-authored papers 13
Harry Benjamin Larman
Institute for Cell Engineering, Johns Hopkins University School of Medicine
Co-authored papers 13
Abraham L Brass
University of Massachusetts Medical School
Co-authored papers 12
Jun Qin
Co-authored papers 8
Yolanda Sanchez
Collegeville
Co-authored papers 6
Chunshui Zhou
Harbin Medical University
Co-authored papers 6
Ramnik J Xavier
Broad Institute of MIT and Harvard
Co-authored papers 6
Ingo Ruczinski
Co-authored papers 4
Itay Koren
Bar-Ilan University
Co-authored papers 4
Hongjing Qu
Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 4
Tak W Mak
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 4
Nikola P Pavletich
Memorial Sloan Kettering Cancer Center
Co-authored papers 4
Thomas Pertel
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Alan D D'Andrea
Dana-Farber Cancer Institute
Co-authored papers 4
Konrad Hochedlinger
Co-authored papers 4
George M Church
Harvard Medical School
Co-authored papers 3
Robert A Davey
Boston University
Co-authored papers 3
Chad J Creighton
Co-authored papers 3
Oliver Laeyendecker
Department of Medicine Johns Hopkins Medicine. Baltimore MD 21205USA.
Co-authored papers 3
Eric N Olson
Co-authored papers 3
Shiaw-Yih Lin
The University of Texas MD Anderson Cancer Center
Co-authored papers 3
Antony Rosen
Johns Hopkins University
Co-authored papers 3
Arturo Casadevall
Johns Hopkins Bloomberg School of Public Health
Co-authored papers 2
C David Allis
The Rockefeller University
Co-authored papers 2
Andrew Pekosz
Co-authored papers 2
Simon J Boulton
The Francis Crick Institute
Co-authored papers 2
Release 1.2