Author details

Full Name

Rahul Roychoudhuri

Affiliation

ORCID

Career Start Year

2004

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37081149	Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy.		2023
36180637	High-Dimensional Single-Cell Profiling of Tumor-Infiltrating CD4 Regulatory T Cells.	Methods in Molecular Biology	2023
37745435	Intracellular K limits T cell exhaustion and preserves antitumor function.		2023
38063845	Intracellular K+ Limits T-cell Exhaustion and Preserves Antitumor Function.		2023
34973390	TCR-induced FOXP3 expression by CD8 T cells impairs their anti-tumor activity.	Cancer Letters	2022
36178457	BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis.	Journal of Experimental Medicine	2022
35738508	Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as a potential therapeutic target.	J Hepatol	2022
36459543	IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.	Science immunology	2022
33838058	CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function.	Immunology	2021
33893050	Multiply restimulated human thymic regulatory T cells express distinct signature regulatory T-cell transcription factors without evidence of exhaustion.	Cytotherapy	2021
32499651	A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T<sub>reg</sub> cells.	Nature	2020
32125291	IRF4 instructs effector Treg differentiation and immune suppression in human cancer.	Journal of Clinical Investigation	2020
33144667	A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2.	Scientific Reports	2020
32515782	BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression.	Journal of Experimental Medicine	2020
30778251	The transcription factor c-Myb regulates CD8<sup>+</sup> T cell stemness and antitumor immunity.	Nat Immunol	2019
31032905	Regulation of regulatory T cells in cancer.	Immunology	2019
30923193	T cell stemness and dysfunction in tumors are triggered by a common mechanism.	Science	2019
31225653	Regulatory T cells in cancer: where are we now?	Immunology	2019
31483104	Genome-Wide Measurement and Computational Analysis of Transcription Factor Binding and Chromatin Accessibility in Lymphocytes.	Current Protocols in Immunology	2019
29540581	Bach2 Promotes B Cell Receptor-Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase Inhibitors.	Journal of Immunology	2018
29875321	Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.	JCI insight	2018
29875319	Phosphoinositide 3-kinase Î´ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors.	JCI insight	2018
30133745	Paths to expansion: Differential requirements of IRF4 in CD8 T-cell expansion driven by antigen and homeostatic cytokines.	European Journal of Immunology	2018
29379213	Epigenetic control of CD8<sup>+</sup> T cell differentiation.	Nat Rev Immunol	2018
28530713	BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.	Nat Immunol	2017
28461702	BACH transcription factors in innate and adaptive immunity.	Nature Reviews Immunology	2017
27626381	Ionic immune suppression within the tumour microenvironment limits T cell effector function.	Nature	2016
25914936	Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape.	Cell Mol Immunol	2016
26731475	The transcription factor BACH2 promotes tumor immunosuppression.	J Clin Invest	2016
27158840	BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.	Nat Immunol	2016
26657860	Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.	J Clin Invest	2016
26674251	Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.	Cell Metab	2016
27565342	Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.	Cell	2016
27554085	Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes.	Blood	2016
26527801	Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance.	J Exp Med	2015
25548153	miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic Î³c cytokines.	Proc Natl Acad Sci U S A	2015
25446821	Transcriptional profiles reveal a stepwise developmental program of memory CD8(+) T cell differentiation.	Vaccine	2015
25358764	Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest.	Cancer Immunol Res	2015
25686607	Super-enhancers delineate disease-associated regulatory nodes in T cells.	Nature	2015
25432172	Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.	Cancer Res	2015
25728990	The interplay of effector and regulatory T cells in cancer.	Curr Opin Immunol	2015
26359979	Nutrient Competition: A New Axis of Tumor Immunosuppression.	Cell	2015
25998054	The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.	Elife	2015
26503445	Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection.	Journal of Experimental Medicine	2015
26535006	Oncogenic PI3KÎ± promotes multipotency in breast epithelial cells.	Science Signaling	2015
24827921	Identification of the genomic insertion site of Pmel-1 TCR Î± and Î² transgenes by next-generation sequencing.	PLoS One	2014
23728300	BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.	Nature	2013
23999499	Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells.	J Exp Med	2013
24091329	Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.	J Clin Invest	2013
22593152	Gene-based vaccination with a mismatched envelope protects against simian immunodeficiency virus infection in nonhuman primates.	J Virol	2012