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Author Details

Jie J Zheng
Molecular Biology Institute, University of California los angeles
1989
99
44
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37368816Dexamethasone Modulates the Dynamics of Wnt Signaling in Human Trabecular Meshwork Cells.Vision (Basel)2023
34896106Characterizing the metabolic profile of dexamethasone treated human trabecular meshwork cells.Exp Eye Res2022
36471035Stability and Function of Extracellular Vesicles Derived from Immortalized Human Corneal Stromal Stem Cells: A Proof of Concept Study.AAPS J2022
35243012R-etodolac is a more potent Wnt signaling inhibitor than enantiomer, S-etodolac.Biochem Biophys Rep2022
33391527Three-dimensional Imaging Coupled with Topological Quantification Uncovers Retinal Vascular Plexuses Undergoing Obliteration.Theranostics2021
33676006Human limbal epithelial stem cell regulation, bioengineering and function.Prog Retin Eye Res2021
34458828Wnt signaling activation: targets and therapeutic opportunities for stem cell therapy and regenerative medicine.RSC Chem Biol2021
34541033Loss of CDCP1 triggers FAK activation in detached prostate cancer cells.Am J Clin Exp Urol2021
34686698Wnt6 plays a complex role in maintaining human limbal stem/progenitor cells.Sci Rep2021
32361505A Small-Molecule Wnt Mimic Improves Human Limbal Stem Cell Ex Vivo Expansion.iScience2020
30640975Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro.Invest Ophthalmol Vis Sci2019
31449795Cellular and cytoskeletal alterations of scleral fibroblasts in response to glucocorticoid steroids.Exp Eye Res2019
30963607Oxidative stress upregulates Wnt signaling in human retinal microvascular endothelial cells through activation of disheveled.J Cell Biochem2019
28985478Alteration of RNA Splicing by Small-Molecule Inhibitors of the Interaction between NHP2L1 and U4.SLAS Discov2018
29608908CINPA1 binds directly to constitutive androstane receptor and inhibits its activity.Biochem Pharmacol2018
28860193Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin.J Biol Chem2017
28223363Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways.J Biol Chem2017
28120389Modulating the wnt signaling pathway with small molecules.Protein Sci2017
28963450SPA70 is a potent antagonist of human pregnane X receptor.Nat Commun2017
28526237Small-molecule inhibition of Wnt signaling abrogates dexamethasone-induced phenotype of primary human trabecular meshwork cells.Exp Cell Res2017
28684529Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox.Cancer Res2017
26866573Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.Biochemistry2016
27607449GNAI3: Another Candidate Gene to Screen in Persons with Ocular Albinism.PLoS One2016
26833677Drug Repurposing Identifies Inhibitors of Oseltamivir-Resistant Influenza Viruses.Angew Chem Int Ed Engl2016
27030405KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles.Sci Rep2016
25710658Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.JAMA2015
26297804Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways.Elife2015
26504084Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled.J Biol Chem2015
26576726Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death.Sci Rep2015
25174335Structural and mechanistic insights into the interaction between Pyk2 and paxillin LD motifs.J Mol Biol2014
25306923Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.Mol Cell2014
24132329Genome-wide network analysis of Wnt signaling in three pediatric cancers.Sci Rep2013
24351982Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling.Nat Commun2013
22172211Synthesis of potent dishevelled PDZ domain inhibitors guided by virtual screening and NMR studies.Chem Biol Drug Des2012
22956130Virtual ligand screening combined with NMR to identify Dvl PDZ domain inhibitors targeting the Wnt signaling.Methods Mol Biol2012
22733757Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.Proc Natl Acad Sci U S A2012
22589387The structural basis of DKK-mediated inhibition of Wnt/LRP signaling.Sci Signal2012
22584113Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen.BMC Chem Biol2012
21455495Rational design of T cell receptors with enhanced sensitivity for antigen.PLoS One2011
22079629Tetraspanins regulate the protrusive activities of cell membrane.Biochem Biophys Res Commun2011
20160075Macrophage Wnt7b is critical for kidney repair and regeneration.Proc Natl Acad Sci U S A2010
21044957Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein.J Biol Chem2010
20509869PDZ domains and their binding partners: structure, specificity, and modification.Cell Commun Signal2010
18780146Optimizing Dvl PDZ domain inhibitor by exploring chemical space.J Comput Aided Mol Des2009
19637179Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled.Angew Chem Int Ed Engl2009
19383605Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.J Biol Chem2009
19177367Structural modification of acyl carrier protein by butyryl group.Protein Sci2009
19116362Transmembrane interactions are needed for KAI1/CD82-mediated suppression of cancer invasion and metastasis.Am J Pathol2009
19157887Identification of tripeptides recognized by the PDZ domain of Dishevelled.Bioorg Med Chem2009
19234454Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization.Nat Cell Biol2009
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Collaborators

David Cowburn
Albert Einstein College of Medicine
Co-authored papers 11
Beatrice S Knudsen
University of Utah
Co-authored papers 6
Stephan M Feller
Institute of Molecular Medicine, Martin-Luther-University of Halle-Wittenberg
Co-authored papers 5
Taosheng Chen
St. Jude Children's Research Hospital
Co-authored papers 4
Hidesaburo Hanafusa
Rockefeller University
Co-authored papers 3
Wenwei Lin
St. Jude Children's Research Hospital
Co-authored papers 3
Sean Cahill
The Fenway Institute
Co-authored papers 3
Yi Zheng
Children's Hospital Research Foundation
Co-authored papers 3
William E Evans
Departments of Oncology. St. Jude Children's Research Hospital
Co-authored papers 3
Mary V Relling
Departments of Pharmaceutical Sciences.
Co-authored papers 3
David Fushman
University of Maryland, College Park
Co-authored papers 2
Jose A Cancelas
Cincinnati Children's Hospital Medical Center
Co-authored papers 2
Wenqing Xu
Co-authored papers 2
John Kuriyan
University of California berkeley
Co-authored papers 2
Ching-Hon Pui
St. Jude Children's Research Hospital
Co-authored papers 2
Patrick R Griffin
The Scripps Research Institute
Co-authored papers 2
Anang A Shelat
St. Jude Children's Research Hospital
Co-authored papers 2
Kristine R Crews
St. Jude Children's Research Hospital
Co-authored papers 1
Cai Huang
Markey Cancer Center, University of Kentucky 789 South Limestone St
Co-authored papers 1
Jie-Fu Chen
Memorial Sloan Kettering Cancer Center
Co-authored papers 1
Mary Eileen Dolan
University of Chicago
Co-authored papers 1
Javier Mariscal
Samuel Oschin Comprehensive Cancer Institute
Co-authored papers 1
Kristina I Boström
Co-authored papers 1
Phuong Nguyen
Hoag Memorial Hospital Presbyterian
Co-authored papers 1
Michael Boutros
German Cancer Research Center (DKFZ) and Heidelberg University
Co-authored papers 1
Kun Guo
Co-authored papers 1
Kyung In Baek
Co-authored papers 1
Geoffrey Neale
St. Jude Children's Research Hospital
Co-authored papers 1
Lynn K Gordon
Co-authored papers 1
Stephen P Hunger
Children's Hospital of Philadelphia
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Release 1.2