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Author Details

Tomohiro Nakamura
The Scripps Research Institute
2004
67
39
PMIDPaper TitleJournal TitlePublished Year
36175661Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection.Nat Chem Biol2023
37478858S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons.Cell Chem Biol2023
36817649Aberrant protein S-nitrosylation contributes to hyperexcitability-induced synaptic damage in Alzheimer's disease: Mechanistic insights and potential therapies.Front Neural Circuits2023
36739439Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis.Nat Commun2023
35169022S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia.J Neurosci2022
35411336Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection.bioRxiv2022
35462559S-Nitrosylation of cathepsin B affects autophagic flux and accumulation of protein aggregates in neurodegenerative disorders.Cell Death Differ2022
36516243Mechanistic insight into female predominance in Alzheimer's disease based on aberrant protein S-nitrosylation of C3.Sci Adv2022
36314651Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging.EMBO J2022
32467645NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models.Mol Psychiatry2021
33692125S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD.Proc Natl Acad Sci U S A2021
33942273Correction to: TCA cycle metabolic compromise due to an aberrant Sâ¿¿nitrosoproteome in HIVâ¿¿associated neurocognitive disorder with methamphetamine use.J Neurovirol2021
33957758Protein Transnitrosylation Signaling Networks Contribute to Inflammaging and Neurodegenerative Disorders.Antioxid Redox Signal2021
34224817Protein S-nitrosylation and oxidation contribute to protein misfolding in neurodegeneration.Free Radic Biol Med2021
33273062Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer's disease.Science2021
31657228Nitric Oxide-Dependent Protein Post-Translational Modifications Impair Mitochondrial Function and Metabolism to Contribute to Neurodegenerative Diseases.Antioxid Redox Signal2020
30928642NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model.Neurobiol Dis2019
29166608S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models.Cell Rep2017
29097102'SNO'-Storms Compromise Protein Activity and Mitochondrial Metabolism in Neurodegenerative Disorders.Trends Endocrinol Metab2017
26118537Nitrosative Stress in the Nervous System: Guidelines for Designing Experimental Strategies to Study Protein S-Nitrosylation.Neurochem Res2016
27821734Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons.Proc Natl Acad Sci U S A2016
27473602S-Nitrosylation Induces Structural and Dynamical Changes in a Rhodanese Family Protein.J Mol Biol2016
26743041Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation.Nat Commun2016
26707925Protein S-Nitrosylation as a Therapeutic Target for Neurodegenerative Diseases.Trends Pharmacol Sci2016
26867695Corrigendum: Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease.Sci Rep2016
25796565Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases.Neurobiol Dis2015
26477507Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease.Sci Rep2015
26446798Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress.Sci Rep2015
24091828Potential effect of S-nitrosylated protein disulfide isomerase on mutant SOD1 aggregation and neuronal cell death in amyotrophic lateral sclerosis.Mol Neurobiol2014
25378175Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.J Neurosci2014
25001280S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death.Cell Rep2014
22657837Emerging role of protein-protein transnitrosylation in cell signaling pathways.Antioxid Redox Signal2013
24587691Dysfunctional Mitochondrial Dynamics in the Pathophysiology of Neurodegenerative Diseases.J Cell Death2013
24290359Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.Cell2013
23985028S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease.Mol Neurodegener2013
23641925S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease.Antioxid Redox Signal2013
23776240Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss.Proc Natl Acad Sci U S A2013
23719160Aberrant protein s-nitrosylation in neurodegenerative diseases.Neuron2013
23382182S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke.Proc Natl Acad Sci U S A2013
22575597Isobaric tagging-based quantification by mass spectrometry of differentially regulated proteins in synaptosomes of HIV/gp120 transgenic mice: implications for HIV-associated neurodegeneration.Exp Neurol2012
22956959Redox Regulation of Protein Function via Cysteine S-Nitrosylation and Its Relevance to Neurodegenerative Diseases.Int J Cell Biol2012
22771760Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases.Exp Neurol2012
22874667S-nitrosylation of Cdk5: potential implications in amyloid-β-related neurotoxicity in Alzheimer disease.Prion2012
20812868S-nitrosylation of critical protein thiols mediates protein misfolding and mitochondrial dysfunction in neurodegenerative diseases.Antioxid Redox Signal2011
21844361S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide.Proc Natl Acad Sci U S A2011
21597461Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases.Cell Death Differ2011
21646525On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN).Proc Natl Acad Sci U S A2011
20060165Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies.Cell Calcium2010
20447471S-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration.Mitochondrion2010
20577776Mitochondrial dynamics in cell death and neurodegeneration.Cell Mol Life Sci2010
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Collaborators

Stuart A Lipton
The Scripps Research Institute, University of California
Co-authored papers 67
John R Yates
TheScripps Research Institute
Co-authored papers 11
Eliezer Masliah
National Institute On Aging
Co-authored papers 9
Rajesh Ambasudhan
The Scripps Research Institute
Co-authored papers 7
Nima Dolatabadi
The Scripps Research Institute
Co-authored papers 7
Maria Talantova
The Scripps Research Institute
Co-authored papers 7
Xuemei Han
Co-authored papers 6
Swagata Ghatak
National Institute of Science Education and Research
Co-authored papers 5
Piotr Cieplak
Sanford-Burnham-Prebys Medical Discovery Institute
Co-authored papers 5
Abdullah Sultan
King Abdulaziz University
Co-authored papers 4
Dorit Trudler
Tel Aviv University
Co-authored papers 4
Amanda J Roberts
The Scripps Research Institute
Co-authored papers 3
Adam Godzik
University of California Riverside
Co-authored papers 3
Ian A Wilson
The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 2
Bing Shan
Co-authored papers 2
Harry Ischiropoulos
Co-authored papers 2
Roland Riek
ETH Zurich
Co-authored papers 2
Alexander Y Andreyev
Co-authored papers 2
Malina A Bakowski
a division of The Scripps Research Institute La Jolla
Co-authored papers 2
Rommie E Amaro
University of California
Co-authored papers 2
Richard Gao
University of Tubingen
Co-authored papers 1
Matthew E Albertolle
Co-authored papers 1
Innokentiy Maslennikov
School of Pharmacy , Chapman University
Co-authored papers 1
Maria T Diaz-Meco
Co-authored papers 1
Daniel B McClatchy
Co-authored papers 1
Matthew W Buczynski
Co-authored papers 1
Bradley Voytek
Alfred P. Sloan Foundation, National Academy of Sciences, University of California Berkeley, University of California San Diego, University of California, San Diego
Co-authored papers 1
C??dric Eichmann
ETH Zurich
Co-authored papers 1
Witek Kwiatkowski
Swiss Federal Institute of Technology
Co-authored papers 1
Gen-Sheng Feng
Co-authored papers 1
Release 1.2