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Author Details

Prashant Mali (CM4AI)
University of California San Diego
0000-0002-3383-1287
2004
221
55
Data acquisition
PMIDPaper TitleJournal TitlePublished Year
36596361Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ-focal adhesion kinase signaling circuitry.J Biol Chem2023
37577681Interface-guided phenotyping of coding variants in the transcription factor RUNX1 with SEUSS.bioRxiv2023
37252678Systematic discovery of transcription factors that improve hPSC-derived cardiomyocyte maturation via temporal analysis of bioengineered cardiac tissues.APL Bioeng2023
37169829Multimodal perturbation analyses of cyclin-dependent kinases reveal a network of synthetic lethalities associated with cell-cycle regulation and transcriptional regulation.Sci Rep2023
36697822Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.Nature2023
36620962RNA editing: Expanding the potential of RNA therapeutics.Mol Ther2023
35145312Efficient in vitro and in vivo RNA editing via recruitment of endogenous ADARs using circular guide RNAs.Nat Biotechnol2022
35779766Methods for recruiting endogenous and exogenous ADAR enzymes for site-specific RNA editing.Methods2022
36055970Scalable Functional Assays for the Interpretation of Human Genetic Variation.Annu Rev Genet2022
35981511What are the current bottlenecks in developing and applying CRISPR technologies?Cell Syst2022
34890975Integrated genome and tissue engineering enables screening of cancer vulnerabilities in physiologically relevant perfusable ex vivo cultures.Biomaterials2022
35044296Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity.Elife2022
34051140Peptide-tiling screens of cancer drivers reveal oncogenic protein domains and associated peptide inhibitors.Cell Syst2021
33568347Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for <i>GNAQ</i>-Driven Uveal Melanoma.Clin Cancer Res2021
33692551Lineage barcoding in mice with homing CRISPR.Nat Protoc2021
33692134Long-lasting analgesia via targeted in situ repression of Na<sub>V</sub>1.7 in mice.Sci Transl Med2021
34646987Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas.iScience2021
34389658Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for <i>GNAQ</i>-Driven Uveal Melanoma.Clin Cancer Res2021
34559998Programmatic introduction of parenchymal cell types into blood vessel organoids.Stem Cell Reports2021
32462051CRISPR-Cas9 Gene Editing of Hematopoietic Stem Cells from Patients with Friedreich's Ataxia.Mol Ther Methods Clin Dev2020
33152263Defining the Teratoma as a Model for Multi-lineage Human Development.Cell2020
32833535Translating CRISPR-Cas Therapeutics: Approaches and Challenges.CRISPR J2020
32637855Mapping regulators of cell fate determination: Approaches and challenges.APL Bioeng2020
32603653In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation.Mol Ther2020
30663717Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays.J Vis Exp2019
29959923Functional Genomics via CRISPR-Cas.J Mol Biol2019
31455920Author Correction: Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy.Nat Biomed Eng2019
31251918Humanizing Transcriptome Engineering.Cell2019
31332341Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy.Nat Biomed Eng2019
30737497In vivo RNA editing of point mutations via RNA-guided adenosine deaminases.Nat Methods2019
30943016RNA-Guided Adenosine Deaminases: Advances and Challenges for Therapeutic RNA Editing.Biochemistry2019
29452643Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis.Mol Cell2018
30093604Developmental barcoding of whole mouse via homing CRISPR.Science2018
30369101Facile Engineering of Long-Term Culturable Ex Vivo Vascularized Tissues Using Biologically Derived Matrices.Adv Healthc Mater2018
30448000Mapping Cellular Reprogramming via Pooled Overexpression Screens with Paired Fitness and Single-Cell RNA-Sequencing Readout.Cell Syst2018
29754775In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation.Mol Ther2018
29483550Oligonucleotide conjugated multi-functional adeno-associated viruses.Sci Rep2018
27918539Rapidly evolving homing CRISPR barcodes.Nat Methods2017
28198142Therapeutic genome engineering via CRISPR-Cas systems.Wiley Interdiscip Rev Syst Biol Med2017
28481362Genetic interaction mapping in mammalian cells using CRISPR interference.Nat Methods2017
28319113Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.Nat Methods2017
28991237Corrigendum: Engineering and optimising deaminase fusions for genome editing.Nat Commun2017
27595405A multifunctional AAV-CRISPR-Cas9 and its host response.Nat Methods2016
27804970Engineering and optimising deaminase fusions for genome editing.Nat Commun2016
25414332Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells.Nucleic Acids Res2015
26167643Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach.Nat Methods2015
24578530Highly multiplexed subcellular RNA sequencing in situ.Science2014
25398338Genome editing in human stem cells.Methods Enzymol2014
24557908CRISPR-Cas-mediated targeted genome editing in human cells.Methods Mol Biol2014
23287722RNA-guided human genome engineering via Cas9.Science2013
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Collaborators

George M Church
Harvard Medical School
Co-authored papers 17
Linzhao Cheng
Johns Hopkins University School of Medicine
Co-authored papers 16
Dhruva Katrekar
University of California San Diego
Co-authored papers 10
Zhaohui Ye
Center for Biologics Evaluation and Research
Co-authored papers 10
Ana M Moreno
University of California San Diego
Co-authored papers 9
John Aach
Harvard Medical School
Co-authored papers 9
Kyle Ford
University of California San Diego
Co-authored papers 7
Luhan Yang
College of Resources and Environment, Southwest University
Co-authored papers 7
Daniella McDonald
University of California San Diego
Co-authored papers 7
Jizhong Zou
and Blood Institute, National Institutes of Health
Co-authored papers 6
Udit Parekh
University of California San Diego
Co-authored papers 6
Nathan Palmer
University of California San Diego
Co-authored papers 6
Wei Leong Chew
Genome Institute of Singapore
Co-authored papers 5
Trey Ideker (CM4AI)
University of California San Diego
Co-authored papers 5
Sarah N Dowey
Johns Hopkins University School of Medicine, Institute for Cell Engineering
Co-authored papers 5
Bin-Kuan Chou
The Institute for Cell Engineering, Johns Hopkins University
Co-authored papers 5
Amir Dailamy (CM4AI)
University of California San Diego
Co-authored papers 5
Genghao Chen
Harvard Medical School
Co-authored papers 5
Michael Hu
University of California San Diego
Co-authored papers 4
Jonathan Yen
St. Jude Children's Research Hospital
Co-authored papers 4
Marc G??ell
Universitat Pompeu Fabra
Co-authored papers 4
Guibin Chen
and Blood Institute, National Institutes of Health
Co-authored papers 4
Kevin M Esvelt
Massachusetts Institute of Technology
Co-authored papers 4
Kun Zhang
China Pharmaceutical University
Co-authored papers 4
Xavier Rios
Texas Children's Hospital, Baylor College of Medicine
Co-authored papers 4
Adrian W Briggs
Harvard University
Co-authored papers 4
Hamid R Kalhor
Sharif University of Technology
Co-authored papers 4
Aditya Kumar
Rice University, University of California San Diego
Co-authored papers 4
Dongxin Zhao
University of California
Co-authored papers 4
Dario Meluzzi
University of California San Diego
Co-authored papers 4
Release 1.2