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Author Details

Lluis Ballell
Global Health Pharma Unit
2005
76
29
PMIDPaper TitleJournal TitlePublished Year
36533912Tyrosine Kinase Inhibitors Display Potent Activity against Cryptosporidium parvum.Microbiol Spectr2023
37535741<i>Delftia tsuruhatensis</i> TC1 symbiont suppresses malaria transmission by anopheline mosquitoes.Science2023
37565760Novel inhibitors that target bacterial virulence identified via HTS against intra-macrophage survival of <i>Shigella flexneri</i>.mSphere2023
36602336Cyclic AMP-Mediated Inhibition of Cholesterol Catabolism in <i>Mycobacterium tuberculosis</i> by the Novel Drug Candidate GSK2556286.Antimicrob Agents Chemother2023
35607978GSK2556286 Is a Novel Antitubercular Drug Candidate Effective <i>In Vivo</i> with the Potential To Shorten Tuberculosis Treatment.Antimicrob Agents Chemother2022
35507672The small-molecule SMARt751 reverses <i>Mycobacterium tuberculosis</i> resistance to ethionamide in acute and chronic mouse models of tuberculosis.Sci Transl Med2022
34534310Tebipenem as an oral alternative for the treatment of typhoid caused by XDR Salmonella Typhi.J Antimicrob Chemother2021
33909975Fighting <i>Shigella</i> by Blocking Its Disease-Causing Toxin.J Med Chem2021
33740373Repurposing Infectious Disease Hits as Anti-<i>Cryptosporidium</i> Leads.ACS Infect Dis2021
34471283Tres Cantos Open Lab: celebrating a decade of innovation in collaboration to combat endemic infectious diseases.Nat Rev Drug Discov2021
32342688Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-β-d-Ribose Oxidase (DprE1) Inhibitors.J Med Chem2020
32275415MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against <i>Mycobacterium tuberculosis</i>.J Med Chem2020
31620228Novel Pyrazole-Containing Compounds Active against <i>Mycobacterium tuberculosis</i>.ACS Med Chem Lett2019
31850398An open toolkit for tracking open science partnership implementation and impact.Gates Open Res2019
29335214In vivo potent BM635 analogue with improved drug-like properties.Eur J Med Chem2018
30140040Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach.Sci Rep2018
30194385Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1.Sci Rep2018
30004092Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.Nat Commun2018
30500189Identification and Profiling of Hydantoins-A Novel Class of Potent Antimycobacterial DprE1 Inhibitors.J Med Chem2018
29500372Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets.Sci Rep2018
29632076The antibiotic cyclomarin blocks arginine-phosphate-induced millisecond dynamics in the N-terminal domain of ClpC1 from <i>Mycobacterium tuberculosis</i>.J Biol Chem2018
29661879Accelerating Early Antituberculosis Drug Discovery by Creating Mycobacterial Indicator Strains That Predict Mode of Action.Antimicrob Agents Chemother2018
29706526Synthesis, antimycobacterial activity and influence on mycobacterial InhA and PknB of 12-membered cyclodepsipeptides.Bioorg Med Chem2018
29453370A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK.Sci Rep2018
27704782Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.ACS Infect Dis2017
28475832A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors.ACS Infect Dis2017
28423019Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent.PLoS One2017
29148755Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.J Med Chem2017
29018348Target Identification of <i>Mycobacterium tuberculosis</i> Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.Front Pharmacol2017
28842600Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.Sci Rep2017
28714473Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.Nat Commun2017
27939618Pharmaceutical salt of BM635 with improved bioavailability.Eur J Pharm Sci2017
26900657New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.Eur J Med Chem2016
27982051Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen.Sci Rep2016
27581223Identification of KasA as the cellular target of an anti-tubercular scaffold.Nat Commun2016
27678056Repurposing clinically approved cephalosporins for tuberculosis therapy.Sci Rep2016
27428438Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.EBioMedicine2016
27121350A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.Mol Microbiol2016
27348630Searching for New Leads for Tuberculosis: Design, Synthesis, and Biological Evaluation of Novel 2-Quinolin-4-yloxyacetamides.J Med Chem2016
27571973THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria.Nat Microbiol2016
27433841β-Lactams against Tuberculosis--New Trick for an Old Dog?N Engl J Med2016
27020099Open Lab as a source of hits and leads against tuberculosis, malaria and kinetoplastid diseases.Nat Rev Drug Discov2016
26934341N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity.ChemMedChem2016
25348525High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis.Antimicrob Agents Chemother2015
26449457Non-absorbable mesoporous silica for the development of protein sequestration therapies.Biochem Biophys Res Commun2015
26642067Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery.PLoS One2015
27623058Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase.ACS Infect Dis2015
26771003A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.ACS Infect Dis2015
26149997Hydrolysis of clavulanate by Mycobacterium tuberculosis β-lactamase BlaC harboring a canonical SDN motif.Antimicrob Agents Chemother2015
26222445Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.J Med Chem2015
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Collaborators

University of Birmingham
Co-authored papers 6
European Molecular Biology Laboratory - European Bioinformatics Institute
Co-authored papers 3
Institute of Cardiovascular Science, University College London
Co-authored papers 3
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University of Dundee
Co-authored papers 2
Xijing Hospital, The Fourth Military Medical University
Co-authored papers 2
Heartand Lung Research Institute, University of Cambridge
Co-authored papers 2
Co-authored papers 2
GlaxoSmithKline Pharma R&D, 1250 S. Collegeville Rd, Collegeville
Co-authored papers 1
Co-authored papers 1
McGill University
Co-authored papers 1
Co-authored papers 1
Instituto Goncalo Moniz
Co-authored papers 1
Arizona State University
Co-authored papers 1
Institute of Education, University of London
Co-authored papers 1
Warwick Medical School, University of Warwick
Co-authored papers 1
University of Wolverhampton
Co-authored papers 1
Ipswich Hospital
Co-authored papers 1
a division of The Scripps Research Institute La Jolla
Co-authored papers 1
Instituto Oswaldo Cruz
Co-authored papers 1
Queensland University of Technology
Co-authored papers 1
McGill University
Co-authored papers 1
Center for Open Science
Co-authored papers 1
Children's Hospital Oakland Research Institute
Co-authored papers 1
McGill University
Co-authored papers 1
African Academy of Sciences
Co-authored papers 1
US Department of Agriculture Economic Research Service
Co-authored papers 1
University of Wales
Co-authored papers 1
Montreal Neurological Institute-Hospital
Co-authored papers 1
Co-authored papers 1