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Author Details

Mark Levine
Molecular and Clinical Nutrition Section
1983
165
59
PMIDPaper TitleJournal TitlePublished Year
36897309Red Blood Cell Vitamin C Concentration and Its Effect on Deformability in Pediatric Sickle Cell Disease.J Pediatr Hematol Oncol2023
37264998Vitamin C Urinary Loss and Deficiency in Human Immunodeficiency Virus (HIV): Cross-sectional Study of Vitamin C Renal Leak in Women With HIV.Clin Infect Dis2023
36248829Vitamin C deficiency reveals developmental differences between neonatal and adult hematopoiesis.Front Immunol2022
35537862Abnormal urinary loss of vitamin C in diabetes: prevalence and clinical characteristics of a vitamin C renal leak.Am J Clin Nutr2022
35750958Pharmacokinetic Evaluation of Intravenous Vitamin C: A Classic Pharmacokinetic Study.Clin Pharmacokinet2022
35681624A Histone Deacetylase Inhibitor Induces Acetyl-CoA Depletion Leading to Lethal Metabolic Stress in RAS-Pathway Activated Cells.Cancers (Basel)2022
33184629Vitamin E catabolism in women, as modulated by food and by fat, studied using 2 deuterium-labeled α-tocopherols in a 3-phase, nonrandomized crossover study.Am J Clin Nutr2021
33512468Dietary iron restriction improves markers of disease severity in murine sickle cell anemia.Blood2021
33620405Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.JAMA2021
32920226Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis.Redox Biol2020
31821172Vitamin E sequestration by liver fat in humans.JCI Insight2020
31911474High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model.Proc Natl Acad Sci U S A2020
31495886Vitamin E absorption and kinetics in healthy women, as modulated by food and by fat, studied using 2 deuterium-labeled α-tocopherols in a 3-phase crossover design.Am J Clin Nutr2019
31801567Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.Trials2019
29438178Treatment of pancreatic cancer with intravenous vitamin C: a case report.Anticancer Drugs2018
30002308Systematic Review of Intravenous Ascorbate in Cancer Clinical Trials.Antioxidants (Basel)2018
30174242Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly.Cancer Cell2018
29364234Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry.J Vis Exp2018
28003207Breaking down, starting up: can a vitamin C-enriched gelatin supplement before exercise increase collagen synthesis?Am J Clin Nutr2017
28399404Data Triumph at C.Cancer Cell2017
28292579Pharmacologic Ascorbate in Myeloma Treatment: Doses Matter.EBioMedicine2017
28472705Measurements of red cell deformability and hydration reflect HbF and HbA<sub>2</sub> in blood from patients with sickle cell anemia.Blood Cells Mol Dis2017
28177761Temporo-spacial microanatomical distribution of the murine sodium-dependent ascorbic acid transporters Slc23a1 and Slc23a2 in the kidney throughout development.Biochem Cell Biol2017
29140484State of the Science: Cancer Complementary and Alternative Medicine Therapeutics Research-NCI Strategic Workshop Highlights of Discussion Report.J Natl Cancer Inst Monogr2017
29215048High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study.Sci Rep2017
28971850The <i>SLC2A14</i> gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease.Am J Clin Nutr2017
28851583Chemical Transport Knockout for Oxidized Vitamin C, Dehydroascorbic Acid, Reveals Its Functions in vivo.EBioMedicine2017
27036367Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity.Free Radic Biol Med2016
26444610Importance of methodological standardization for the ektacytometric measures of red blood cell deformability in sickle cell anemia.Clin Hemorheol Microcirc2016
26808119Vitamin C: the known and the unknown and Goldilocks.Oral Dis2016
25994956High-dose ascorbate with low-dose amphotericin B attenuates severity of disease in a model of the reappearance of candidemia during sepsis in the mouse.Am J Physiol Regul Integr Comp Physiol2015
26870799Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid.EBioMedicine2015
26119785Antitumor effect of pharmacologic ascorbate in the B16 murine melanoma model.Free Radic Biol Med2015
24500406High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy.Sci Transl Med2014
24798530Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer.Ann Intern Med2014
23067008Ascorbic acid kills Epstein-Barr virus positive Burkitt lymphoma cells and Epstein-Barr virus transformed B-cells in vitro, but not in vivo.Leuk Lymphoma2013
24400138The human sodium-dependent ascorbic acid transporters SLC23A1 and SLC23A2 do not mediate ascorbic acid release in the proximal renal epithelial cell.Physiol Rep2013
23621620Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics.Antioxid Redox Signal2013
23396969Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8.J Biol Chem2013
23381814Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial.Cancer Chemother Pharmacol2013
23403670Standard-dose vs high-dose multivitamin supplements for HIV.JAMA2013
22174395Measurement of plasma volume using fluorescent silica-based nanoparticles.J Appl Physiol (1985)2012
22522059Vitamin C in mouse and human red blood cells: an HPLC assay.Anal Biochem2012
22272248Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer.PLoS One2012
20558814Hemoglobin and plasma vitamin C levels in patients on peritoneal dialysis.Perit Dial Int2011
22332036Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries.Adv Nutr2011
21798397Prostate imaging modalities that can be used for complementary and alternative medicine clinical studies.Urol Clin North Am2011
21402145Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer.Free Radic Biol Med2011
20032962Major contribution of tubular secretion to creatinine clearance in mice.Kidney Int2010
20554995Pharmacological ascorbic acid suppresses syngeneic tumor growth and metastases in hormone-refractory prostate cancer.In Vivo2010
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Collaborators

National Cancer Institute, National Institutes of Health
Co-authored papers 11
National Cancer Institute, National Institutes of Health
Co-authored papers 6
Department of Food and Nutrition, Kongju National University
Co-authored papers 5
National Institute of Diabetes and Digestive and Kidney Disease
Co-authored papers 3
Co-authored papers 3
Frederick National Laboratory for Cancer Research
Co-authored papers 3
Invitae Corporation
Co-authored papers 3
Emory University
Co-authored papers 2
Berry Consultants LLC
Co-authored papers 2
Johns Hopkins University
Co-authored papers 2
Berry Consultants LLC
Co-authored papers 2
Johns Hopkins School of Medicine
Co-authored papers 2
Center for Cancer Research, National Cancer Institute
Co-authored papers 2
Co-authored papers 2
Johns Hopkins University School of Medicine
Co-authored papers 2
9Stanford University
Co-authored papers 2
Johns Hopkins University School of Medicine
Co-authored papers 2
Co-authored papers 2
Vanderbilt University Medical Center
Co-authored papers 2
Virginia Commonwealth University
Co-authored papers 2
Vanderbilt University
Co-authored papers 2
Vanderbilt University School of Medicine
Co-authored papers 2
Emory University School of Medicine
Co-authored papers 2
Emory University School of Medicine
Co-authored papers 2
Duke University
Co-authored papers 2
Center for Sickle Cell Disease, Howard University College of Medicine
Co-authored papers 2
University of Wisconsin School of Medicine and Public Health
Co-authored papers 2
Eastern Virginia Medical School and Sentara Healthcare
Co-authored papers 2
Johns Hopkins University
Co-authored papers 2
Vanderbilt University Medical Center
Co-authored papers 2