Author details

Full Name

Paul J McLaren

Affiliation

ORCID

Career Start Year

2004

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37532928	Africa-specific human genetic variation near CHD1L associates with HIV-1 load.	Nature	2023
37670157	Author Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load.	Nature	2023
37747237	Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population.		2023
37986808	Transcriptomics and chromatin accessibility in multiple African population samples.	bioRxiv	2023
37261336	Cytokine/chemokine profiles in people with recent infection by .		2023
37534725	A new look at human leukocyte antigen variation in HIV; functional clustering to enhance power for discovery of host genetic associations.		2023
35688805	Expansion of cytotoxic tissue-resident CD8 T cells and CCR6CD161 CD4 T cells in the nasal mucosa following mRNA COVID-19 vaccination.	Nature Communications	2022
36179551	Baseline host determinants of robust human HIV-1 vaccine-induced immune responses: A meta-analysis of 26 vaccine regimens.	EBioMedicine	2022
36170228	Gene expression profiling identifies candidate biomarkers for new latent tuberculosis infections. A cohort study.	PLoS ONE	2022
34611364	A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.	Nat Genet	2021
33489013	Dissemination of <i>Mycobacterium tuberculosis</i> is associated to a <i>SIGLEC1</i> null variant that limits antigen exchange via trafficking extracellular vesicles.	J Extracell Vesicles	2021
34168330	HIV-1 and human genetic variation.	Nat Rev Genet	2021
33534201	Rectal microbiota diversity in Kenyan MSM is inversely associated with frequency of receptive anal sex, independent of HIV status.	AIDS	2021
33173934	Increased CHIP Prevalence Amongst People Living with HIV.	medRxiv	2020
32433252	Sex Work Is Associated With Increased Vaginal Microbiome Diversity in Young Women From Mombasa, Kenya.	Journal of acquired immune deficiency syndromes (1999)	2020
32409920	Minding the gap in HIV host genetics: opportunities and challenges.	Human Genetics	2020
31651980	HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation.	Mol Biol Evol	2020
30602460	HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control.	Proc Natl Acad Sci U S A	2019
30728828	Interaction of the Host and Viral Genome and Their Influence on HIV Disease.	Frontiers in Genetics	2018
29331453	Are privacy-enhancing technologies for genomic data ready for the clinic? A survey of medical experts of the Swiss HIV Cohort Study.	J Biomed Inform	2018
28084001	No Evidence for Association of Î²-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDS.	Ann Hum Genet	2017
28845244	A39â¿¿Human exome sequencing to evaluate the impact of rare coding variation on HIV-1 control.	Virus Evol	2017
28716935	Severe viral respiratory infections in children with <i>IFIH1</i> loss-of-function mutations.	Proc Natl Acad Sci U S A	2017
28968755	Evaluating the Impact of Functional Genetic Variation on HIV-1 Control.	J Infect Dis	2017
29209326	Retroviruses As Myeloid Cell Riders: What Natural Human Siglec-1 "Knockouts" Tell Us About Pathogenesis.	Front Immunol	2017
28012378	Systemic inflammation before and after antiretroviral therapy initiation as a predictor of immune response among HIV-infected individuals in Manitoba.	Cytokine	2017
28182649	Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control.	PLoS Comput Biol	2017
28041642	A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis.	Am J Hum Genet	2017
27790221	Corrigendum: Exome Sequencing Reveals Primary Immunodeficiencies in Children with Community-Acquired <i>Pseudomonas aeruginosa</i> Sepsis.	Front Immunol	2016
27088321	Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans.	AIDS	2016
26996307	Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity.	Cell Host Microbe	2016
26765343	Privacy-preserving genomic testing in the clinic: a model using HIV treatment.	Genet Med	2016
27703454	Exome Sequencing Reveals Primary Immunodeficiencies in Children with Community-Acquired <i>Pseudomonas aeruginosa</i> Sepsis.	Front Immunol	2016
27510803	Identification of Siglec-1 null individuals infected with HIV-1.	Nat Commun	2016
25032819	Vitamin D time profile based on the contribution of non-genetic and genetic factors in HIV-infected individuals of European ancestry.	Antivir Ther	2015
25461247	Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols.	Pharmacogenet Genomics	2015
25522017	Human genetic variation in HIV disease: beyond genome-wide association studies.	Curr Opin HIV AIDS	2015
26553974	Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.	Proc Natl Acad Sci U S A	2015
26642228	The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome.	PLoS Comput Biol	2015
25988890	The impact of host genetic variation on infection with HIV-1.	Nat Immunol	2015
26456283	Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses.	Am J Hum Genet	2015
25980612	Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses.	Retrovirology	2015
24996883	Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection.	Gut	2015
25226169	Disentangling human tolerance and resistance against HIV.	PLoS Biol	2014
25282103	Defining the role of common variation in the genomic and biological architecture of adult human height.	Nat Genet	2014
25490090	A novel Acute Retroviral Syndrome Severity Score predicts the key surrogate markers for HIV-1 disease progression.	PLoS One	2014
25734091	Genome-Wide Association Study of Human Immunodeficiency Virus (HIV)-1 Coreceptor Usage in Treatment-Naive Patients from An AIDS Clinical Trials Group Study.	Open Forum Infect Dis	2014
24428872	GuavaH: a compendium of host genomic data in HIV biology and disease.	Retrovirology	2014
25033082	HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1.	PLoS Pathog	2014
24719475	HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A.	J Infect Dis	2014