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Author Details

Michelle O'Laughlin
McDonnell Genome Institute, Washington University School of Medicine
2003
37
26
PMIDPaper TitleJournal TitlePublished Year
37079859Persistent Molecular Disease in Adult Patients With AML Evaluated With Whole-Exome and Targeted Error-Corrected DNA Sequencing.JCO Precis Oncol2023
37910143Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma.Cancer Res Commun2023
35709710Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.Blood Cancer Discov2022
33704937Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers.N Engl J Med2021
30923101Shared cell of origin in a patient with Erdheim-Chester disease and acute myeloid leukemia.Haematologica2019
29515031Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.JCI Insight2018
29891591A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel <i>RARG</i>-<i>CPSF6</i> fusion.Blood Adv2018
30207916Mutation Clearance after Transplantation for Myelodysplastic Syndrome.N Engl J Med2018
30380364Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.N Engl J Med2018
28067246Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.Nat Commun2017
28082444Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.Blood2017
28215704CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.Cell2017
28872462Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.J Clin Invest2017
27740633Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.Leukemia2017
27788309Brief Report: The Role of Rare Protein-Coding Variants in Anti-Tumor Necrosis Factor Treatment Response in Rheumatoid Arthritis.Arthritis Rheumatol2017
27058228A genomic analysis of Philadelphia chromosome-negative AML arising in patients with CML.Blood Cancer J2016
27959731TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.N Engl J Med2016
27148581A common founding clone with TP53 and PTEN mutations gives rise to a concurrent germ cell tumor and acute megakaryoblastic leukemia.Cold Spring Harb Mol Case Stud2016
27573557Targeted sequencing informs the evaluation of normal karyotype cytopenic patients for low-grade myelodysplastic syndrome.Leukemia2016
27181063Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.Exp Hematol2016
25600023Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells.Leukemia2015
26305651Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.JAMA2015
26492932Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.Blood2015
25849893TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.PLoS One2015
25965570Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo.Cancer Cell2015
25799070Genetic heterogeneity of induced pluripotent stem cells: results from 24 clones derived from a single C57BL/6 mouse.PLoS One2015
24497850Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci.PLoS Genet2014
24613412Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.Cancer Cell2014
23537068The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage.Genome Biol2013
22417201Clonal architecture of secondary acute myeloid leukemia.N Engl J Med2012
22817890The origin and evolution of mutations in acute myeloid leukemia.Cell2012
21415852Recurrent DNMT3A mutations in patients with myelodysplastic syndromes.Leukemia2011
22158538Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.Nat Genet2011
21505135Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML.JAMA2011
20393555Genome remodelling in a basal-like breast cancer metastasis and xenograft.Nature2010
21067377DNMT3A mutations in acute myeloid leukemia.N Engl J Med2010
12853948The DNA sequence of human chromosome 7.Nature2003
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Collaborators

Robert S Fulton
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 32
Catrina Fronick
McDonnell Genome Institute, Washington University in St. Louis School of Medicine
Co-authored papers 25
Timothy J Ley
Washington University School of Medicine
Co-authored papers 25
Matthew J Walter
Washington University School of Medicine in St. Louis
Co-authored papers 22
Richard K Wilson
The Ohio State University
Co-authored papers 22
Christopher A Miller
Washington University School of Medicine
Co-authored papers 22
Peter Westervelt
Washington University School of Medicine
Co-authored papers 20
John F DiPersio
Washington University School of Medicine
Co-authored papers 19
Daniel C Link
Washington University School of Medicine
Co-authored papers 18
Timothy A Graubert
Massachusetts General Hospital
Co-authored papers 17
Sharon E Heath
Washington University School of Medicine.
Co-authored papers 17
Elaine R Mardis
The Ohio State University
Co-authored papers 14
Vincent Magrini
The Ohio State University
Co-authored papers 12
Lukas D Wartman
Washington University School of Medicine in St. Louis
Co-authored papers 11
David E Larson
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 10
Jacqueline E Payton
Washington University School of Medicine.
Co-authored papers 9
Lucinda Fulton
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 9
Malachi Griffith
Washington University
Co-authored papers 8
Jeffery M Klco
St. Jude Children's Research Hospital
Co-authored papers 8
Daniel C Koboldt
Institute for Genomic Medicine, Nationwide Children's Hospital
Co-authored papers 8
Michael D McLellan
McDonnell Genome Institute, Washington University in St. Louis
Co-authored papers 8
Li Ding
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 8
David H Spencer
Washington University School of Medicine.
Co-authored papers 7
Tamara L Lamprecht
St. Jude Children's Research Hospital
Co-authored papers 7
Obi L Griffith
Washington University
Co-authored papers 6
Matthew J Christopher
Washington University School of Medicine
Co-authored papers 6
Sean McGrath
Harvard T.H. Chan School of Public Health
Co-authored papers 5
Ken Chen
University of Texas MD Anderson Cancer Center
Co-authored papers 4
Cyriac Kandoth
University of California los angeles
Co-authored papers 4
Jason Walker
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 4
Release 1.2