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Author Details
Full Name
Sarah R Leist
Affiliation
University of North Carolina at Chapel Hill
ORCID
Career Start Year
2014
Papers
81
H Index
33
Expertise
CM4AI Collaborator
PMID
Paper Title
Journal Title
Published Year
38036767
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance.
Nat Immunol
2024
36565697
Clonal replacement sustains long-lived germinal centers primed by respiratory viruses.
Cell
2023
37756379
A MERS-CoV antibody neutralizes a pre-emerging group 2c bat coronavirus.
Sci Transl Med
2023
37961507
Adjuvant-dependent effects on the safety and efficacy of inactivated SARS-CoV-2 vaccines during heterologous infection by a SARS-related coronavirus.
Res Sq
2023
37749254
Host range, transmissibility and antigenicity of a pangolin coronavirus.
Nat Microbiol
2023
37794071
Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera.
Nat Commun
2023
37672661
The Importance of "Negative" Results: Lipid Lessons in Coronavirus Biology.
Am J Respir Cell Mol Biol
2023
36993423
Mouse Adapted SARS-CoV-2 Model Induces "Long-COVID" Neuropathology in BALB/c Mice.
bioRxiv
2023
37000623
Fc-mediated pan-sarbecovirus protection after alphavirus vector vaccination.
Cell Rep
2023
37163615
Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine.
Sci Transl Med
2023
36711543
Extremely potent pan-sarbecovirus neutralizing antibodies generated by immunization of macaques with an AS03-adjuvanted monovalent subunit vaccine against SARS-CoV-2.
bioRxiv
2023
35194605
A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies.
bioRxiv
2022
35677067
A Multitrait Locus Regulates Sarbecovirus Pathogenesis.
bioRxiv
2022
35857635
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice.
Sci Transl Med
2022
35862771
A Multitrait Locus Regulates Sarbecovirus Pathogenesis.
mBio
2022
36680154
Mouse Adapted SARS-CoV-2 (MA10) Viral Infection Induces Neuroinflammation in Standard Laboratory Mice.
Viruses
2022
36415465
A C57BL/6 Mouse model of SARS-CoV-2 infection recapitulates age- and sex-based differences in human COVID-19 disease and recovery.
Res Sq
2022
36482964
Fc mediated pan-sarbecovirus protection after alphavirus vector vaccination.
bioRxiv
2022
36380759
Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive protection across divergent subgroups.
Res Sq
2022
36192374
IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern.
Nat Commun
2022
35879412
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.
Nat Genet
2022
35038579
Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors.
Mol Ther
2022
33469219
Publisher Correction: A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures.
Nature
2021
33513210
Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice.
PLoS Pathog
2021
33758837
Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice.
bioRxiv
2021
33561864
SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801.
Nature
2021
33532765
Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice.
bioRxiv
2021
34710354
Stabilized coronavirus spike stem elicits a broadly protective antibody.
Cell Rep
2021
34523968
Protective Efficacy of Rhesus Adenovirus COVID-19 Vaccines against Mouse-Adapted SARS-CoV-2.
J Virol
2021
34492082
Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection.
PLoS Pathog
2021
34619077
Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines.
Cell
2021
34159335
Protective efficacy of rhesus adenovirus COVID-19 vaccines against mouse-adapted SARS-CoV-2.
bioRxiv
2021
34270939
COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge.
Immunity
2021
34214046
Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice.
Science
2021
34013261
Common Mechanism of SARS-CoV and SARS-CoV-2 Pathogenesis across Species.
bioRxiv
2021
34289384
Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice.
Cell Rep
2021
33427208
Dissecting strategies to tune the therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022.
JCI Insight
2021
33211088
Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo.
J Exp Med
2021
32253226
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
Sci Transl Med
2020
31924756
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.
Nat Commun
2020
31883094
Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome.
Methods Mol Biol
2020
33031744
A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice.
Cell
2020
33139569
Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection.
Proc Natl Acad Sci U S A
2020
33024969
SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo.
bioRxiv
2020
33160446
Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2.
Cell
2020
33184236
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo.
Science
2020
33046644
Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection.
Proc Natl Acad Sci U S A
2020
33232870
Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as a live virus vaccine candidate.
EBioMedicine
2020
33348607
A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine.
Vaccines (Basel)
2020
32577634
SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness.
bioRxiv
2020
1 - 50 of 81
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Collaborators
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University of North Carolina at Chapel Hill
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Lisa E Gralinski
University of North Carolina at Chapel Hill
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Ande West
University of North Carolina at Chapel Hill
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Stephanie A Montgomery
and Lineberger Comprehensive Cancer Center, University of North Carolina System
Co-authored papers
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Boyd L Yount
University of North Carolina at Chapel Hill
Co-authored papers
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Mark T Heise
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Co-authored papers
12
Rachel L Graham
University of North Carolina
Co-authored papers
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Klaus Schughart
University of Tennessee Health Science Center
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Richard C Boucher
Co-authored papers
9
Mark R Denison
Vanderbilt University Medical Center
Co-authored papers
8
Kenichi Okuda
Co-authored papers
8
Jason S McLellan
Co-authored papers
8
Vineet D Menachery
University of Texas Medical Branch
Co-authored papers
8
Martin T Ferris
University of North Carolina.
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7
Heike Kollmus
Helmholtz Centre for Infection Research
Co-authored papers
6
Neil P King
Co-authored papers
6
James D Chappell
Vanderbilt University Medical Center
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6
Laura J Stevens
Vanderbilt University Medical Center
Co-authored papers
6
Darla R Miller
The University of North Carolina at Chapel Hill
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Scott H Randell
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Fernando Pardo-Manuel de Villena
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Amy C Sims
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