Author details

Full Name

Jacob E Corn

Affiliation

ORCID

Career Start Year

2002

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
35147495	Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin.	Elife	2022
35581059	A CRISPR view on autophagy.	Trends in Cell Biology	2022
35633935	High-level correction of the sickle mutation is amplified during erythroid differentiation.	iScience	2022
35403097	Imaging Unique DNA Sequences in Individual Cells Using a CRISPR-Cas9-Based, Split Luciferase Biosensor.		2022
34914197	Double stranded DNA breaks and genome editing trigger loss of ribosomal protein RPS27A.	FEBS J	2022
33653259	PnB Designer: a web application to design prime and base editor guide RNAs for animals and plants.	BMC Bioinformatics	2021
33661998	Genome editing to model and reverse a prevalent mutation associated with myeloproliferative neoplasms.	PLoS ONE	2021
32603710	The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells.	Molecular Cell	2020
32144410	Author Correction: SLC19A1 transports immunoreactive cyclic dinucleotides.	Nature	2020
32313254	CRISPR off-target detection with DISCOVER-seq.	Nat Protoc	2020
32160526	A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation.	Cell	2020
32483117	Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs.	Nat Commun	2020
32877675	Controlled Cycling and Quiescence Enables Efficient HDR in Engraftment-Enriched Adult Hematopoietic Stem and Progenitor Cells.	Cell Reports	2020
32755585	ATF4 Regulates MYB to Increase Î³-Globin in Response to Loss of Î²-Globin.	Cell Reports	2020
33182997	Crystal Structure and Mechanistic Molecular Modeling Studies of <i>Mycobacterium tuberculosis</i> Diterpene Cyclase Rv3377c.	Biochemistry	2020
31294695	The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells.	Elife	2019
31792376	Advances in genome editing through control of DNA repair pathways.	Nature Cell Biology	2019
30372555	Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair.	Stem Cells	2019
30645582	CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells.	PLoS One	2019
31511694	SLC19A1 transports immunoreactive cyclic dinucleotides.	Nature	2019
31000663	Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq.	Science	2019
29367421	BARD1 is necessary for ubiquitylation of nucleosomal histone H2A and for transcriptional regulation of estrogen metabolism genes.	Proc Natl Acad Sci U S A	2018
29889198	Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms.	J Vis Exp	2018
30011268	In vitro-transcribed guide RNAs trigger an innate immune response via the RIG-I pathway.	PLoS Biology	2018
30011264	Sometimes you're the scooper, and sometimes you get scooped: How to turn both into something good.	PLoS Biol	2018
30054595	CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway.	Nat Genet	2018
30341151	Correction: Atlastins remodel the endoplasmic reticulum for selective autophagy.	Journal of Cell Biology	2018
30143524	Atlastins remodel the endoplasmic reticulum for selective autophagy.	Journal of Cell Biology	2018
29899441	Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation.	Nature	2018
27929752	Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells.	MAbs	2017
28462777	Synthetically modified guide RNA and donor DNA are a versatile platform for CRISPR-Cas9 engineering.	eLife	2017
28854172	Discovery of stimulation-responsive immune enhancers with CRISPR activation.	Nature	2017
28985519	E Pluribus Unum ("Out of Many, One"): CRISPR Modeling of Myeloid Expansion.		2017
28945252	Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements.	Nat Genet	2017
28854082	Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye.	mAbs	2017
28416112	Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.	Structure	2017
28410976	Genome editing via delivery of Cas9 ribonucleoprotein.	Methods	2017
28706995	Disabling Cas9 by an anti-CRISPR DNA mimic.	Sci Adv	2017
28967993	Production of Purified CasRNPs for Efficacious Genome Editing.	Current Protocols in Molecular Biology	2017
29805845	Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA <i>in vivo</i> induces homology-directed DNA repair.	Nat Biomed Eng	2017
28008168	Cornerstones of CRISPR-Cas in drug discovery and therapy.	Nat Rev Drug Discov	2017
27733558	Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells.	Sci Transl Med	2016
26789497	Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA.	Nature Biotechnology	2016
27661255	Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.	Elife	2016
27530320	Non-homologous DNA increases gene disruption efficiency by altering DNA repair outcomes.	Nature Communications	2016
26125593	Co-opting CRISPR to deliver functional RNAs.	Nature Methods	2015
25791083	Biotechnology. A prudent path forward for genomic engineering and germline gene modification.	Science	2015
25621951	USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.	Nature Cell Biology	2015
25965754	CRISPR germline engineering--the community speaks.	Nat Biotechnol	2015
26354440	Using protein motion to read, write, and erase ubiquitin signals.	Journal of Biological Chemistry	2015