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Author Details

Paul C Simpson
1968
115
53
PMIDPaper TitleJournal TitlePublished Year
36997759Norepinephrine links astrocytic activity to regulation of cortical state.Nat Neurosci2023
36637971Increased length-dependent activation of human engineered heart tissue after chronic α-adrenergic agonist treatment: testing a novel heart failure therapy.2023
33275531Cardiac α1A-adrenergic receptors: emerging protective roles in cardiovascular diseases.American Journal of Physiology - Heart and Circulatory Physiology2021
31426700Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist.Circulation Research2019
30412439Reversal of right ventricular failure by chronic α-subtype adrenergic agonist therapy.American Journal of Physiology - Heart and Circulatory Physiology2019
28081170An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice.PLoS ONE2017
28822963α<sub>1A</sub>-Subtype adrenergic agonist therapy for the failing right ventricle.Am J Physiol Heart Circ Physiol2017
28596177Response by Simpson et al to Letter Regarding Article, "Adrenergic Receptors in Individual Ventricular Myocytes: the Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent".Circ Res2017
28780067Novel large-particle FACS purification of adult ventricular myocytes reveals accumulation of myosin and actin disproportionate to cell size and proteome in normal post-weaning development.J Mol Cell Cardiol2017
29216197Shift toward greater pathologic post-myocardial infarction remodeling with loss of the adaptive hypertrophic signaling of alpha1 adrenergic receptors in mice.PLoS ONE2017
29084228A method to increase reproducibility in adult ventricular myocyte sizing and flow cytometry: Avoiding cell size bias in single cell preparations.PLoS One2017
28286875An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity.JACC Basic Transl Sci2017
28219977Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent.Circ Res2017
27453955A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart.JACC: Basic to Translational Science2016
28533737The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid and endocannabinoid metabolites associated with inflammation in vivo.Metabolomics2016
27258143The Alpha-1A Adrenergic Receptor in the Rabbit Heart.PLoS ONE2016
26116709The α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium.American Journal of Physiology - Heart and Circulatory Physiology2015
26358108A New Pathway for Sympathetic Cardioprotection in Heart Failure.Circulation Research2015
25128171Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone.American Journal of Physiology - Heart and Circulatory Physiology2014
24145181Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the cardiac response to chronic catecholamine stimulation.Journal of Cardiovascular Pharmacology2014
24368739Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance.Pharmacological Reviews2014
23355341Intraventricular and interventricular cellular heterogeneity of inotropic responses to α(1)-adrenergic stimulation.Am J Physiol Heart Circ Physiol2013
22871963Synthesis of an in vivo MRI-detectable apoptosis probe.Journal of Visualized Experiments2012
22138689Large-scale discovery of enhancers from human heart tissue.Nat Genet2011
21118696Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure.Journal of Molecular and Cellular Cardiology2011
21360750A molecular MRI probe to detect treatment of cardiac apoptosis in vivo.Magnetic Resonance in Medicine2011
21851824Where are the new drugs to treat heart failure? Introduction to the special issue on "key signaling molecules in hypertrophy and heart failure".Journal of Molecular and Cellular Cardiology2011
21791575Long-term α1A-adrenergic receptor stimulation improves synaptic plasticity, cognitive function, mood, and longevity.Molecular Pharmacology2011
21778428β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes.Circ Res2011
20186881Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse.Journal of Cellular Biochemistry2010
20845893Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves.J Heart Valve Dis2010
20857090Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells.Naunyn-Schmiedeberg's Archives of Pharmacology2010
20038810Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium.J Clin Invest2010
20035030Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive.American Journal of Physiology - Heart and Circulatory Physiology2010
18989658Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific.Naunyn-Schmiedeberg's Archives of Pharmacology2009
19761933The alpha-1D Is the predominant alpha-1-adrenergic receptor subtype in human epicardial coronary arteries.Journal of the American College of Cardiology2009
19888965Alpha1A/B-knockout mice explain the native alpha1D-adrenoceptor's role in vasoconstriction and show that its location is independent of the other alpha1-subtypes.British Journal of Pharmacology2009
19919991{alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium.Circulation: Heart Failure2009
18806813Identification of alpha 1L-adrenoceptor in mice and its abolition by alpha 1A-adrenoceptor gene knockout.British Journal of Pharmacology2008
16905597Left ventricular pressure-volume relationship in conscious mice.Am J Physiol Heart Circ Physiol2007
17283256An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes.Circulation2007
17172694Isolation and culture of adult mouse cardiac myocytes.Methods in Molecular Biology2007
17698731Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse.Circulation2007
17384126Blockade of both alpha1A- and alpha1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery.American Journal of Physiology - Heart and Circulatory Physiology2007
16585965Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload.J Clin Invest2006
16183043Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility.Cardiovascular Research2006
16705673Localization of the mouse alpha1A-adrenergic receptor (AR) in the brain: alpha1AAR is expressed in neurons, GABAergic interneurons, and NG2 oligodendrocyte progenitors.Journal of Comparative Neurology2006
16243914Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator.Am J Physiol Heart Circ Physiol2006
16450074Ischemic preconditioning depends on age and gender.Basic Research in Cardiology2006
16731650Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium.American Journal of Physiology - Heart and Circulatory Physiology2006
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