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Author Details

John Alan Diehl
Case Western Reserve University School of Medicine
1993
204
76
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36063172Induction of the activating transcription factor-4 in the intratumoral CD8+â¿¿T cells sustains their viability and anti-tumor activities.Cancer Immunol Immunother2023
37027010Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma.Mol Cancer Res2023
36525973KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition.Cancer Cell2023
35210557Non-phosphorylatable cyclin D1 mutant potentiates endometrial hyperplasia and drives carcinoma with Pten loss.Oncogene2022
35404405Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function.Cancer Res2022
35637402Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors.Nat Cancer2022
35654839A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression.Nat Cell Biol2022
36070682ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes.Cell Metab2022
36329064Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation.Nat Commun2022
36329064Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation.Nat Commun2022
33998600Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies.J Clin Invest2021
33854239The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.Nature2021
33737385Mutant p53 regulates Survivin to foster lung metastasis.Genes Dev2021
33562589The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate.Biomedicines2021
33925820The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment.Int J Mol Sci2021
34680112Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy.Biomolecules2021
32294323Generation and Characterization of Patient-Derived Head and Neck, Oral, and Esophageal Cancer Organoids.Curr Protoc Stem Cell Biol2020
34124690Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs.Nat Cancer2020
31906838Use of Small-molecule Inhibitory Compound of PERK-dependent Signaling Pathway as a Promising Target-based Therapy for Colorectal Cancer.Curr Cancer Drug Targets2020
32006569Cyclin D degradation by E3 ligases in cancer progression and treatment.Semin Cancer Biol2020
32204380The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases.Int J Mol Sci2020
29345572Breaking the DNA Damage Response via Serine/Threonine Kinase Inhibitors to Improve Cancer Treatment.Curr Med Chem2019
31555743SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors.Sci Adv2019
31211239Glutamine addiction: an Achilles heel in esophageal cancers with dysregulation of CDK4/6.Mol Cell Oncol2019
31491919Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis.Int J Mol Sci2019
31263264ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.Nat Cell Biol2019
31316187Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.Nat Cell Biol2019
31341161Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34.Nat Commun2019
30819079Inhibition of the PERK-Dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease.Curr Alzheimer Res2019
30902831The PKR-Like Endoplasmic Reticulum Kinase Promotes the Dissemination of Myc-Induced Leukemic Cells.Mol Cancer Res2019
29230015A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.Nat Cell Biol2018
29808010Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.Nat Med2018
30093730Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.Nat Med2018
30224477Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells.Proc Natl Acad Sci U S A2018
30087114BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in <i>Kras</i>-Mutant Non-Small Cell Lung Cancer.Cancer Immunol Res2018
29976575IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment.Cancer Res2018
30510992Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells.Cell Mol Gastroenterol Hepatol2018
29555893The Long (lncRNA) and Short (miRNA) of It: TGFβ-Mediated Control of RNA-Binding Proteins and Noncoding RNAs.Mol Cancer Res2018
29739788MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer.Clin Cancer Res2018
27993242HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation.Am J Pathol2017
28387316Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.Nat Commun2017
28196594Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment.Cancer Cell2017
28266275Molecular Basis of Human Diseases and Targeted Therapy Based on Small-Molecule Inhibitors of ER Stress-Induced Signaling Pathways.Curr Mol Med2017
29184176Addendum: A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.Nat Cell Biol2017
29152224Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulum.F1000Res2017
29170450Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.Nat Commun2017
29142209Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.Nat Commun2017
28598439Erratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.Nat Commun2017
28703114Inhibition of PERK-dependent pro-adaptive signaling pathway as a promising approach for cancer treatment.Pol Przegl Chir2017
28825698A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.Nat Cell Biol2017
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Collaborators

Meenhard Herlyn
Ellen and Ronald Caplan Cancer Center, The Wistar Institute
Co-authored papers 17
Adam J Bass
Co-authored papers 16
Akihiro Yoshida
University Hospitals Cleveland Medical Center and Case Western Reserve University
Co-authored papers 10
Laura Pontano Vaites
Harvard Medical School
Co-authored papers 9
Kelly A Whelan
Lewis Katz School of Medicine, Temple University
Co-authored papers 7
Charles J Sherr
St. Jude Children's Research Hospital
Co-authored papers 7
Mareike Simon
Abramson Family Cancer Research Institute, Perelman School of Medicine
Co-authored papers 6
Davide Ruggero
University of California San Francisco
Co-authored papers 4
Nancy L Maas
University of Pennsylvania
Co-authored papers 4
Martine F Roussel
St. Jude Children's Research Hospital
Co-authored papers 3
Peter S Hammerman
Novartis Institutes for BioMedical Research
Co-authored papers 3
Nabeel Bardeesy
Massachusetts General Hospital
Co-authored papers 3
John D Gordan
Quantitative Biosciences Institute (QBI), University of California San Francisco
Co-authored papers 3
J. Wade Harper
Harvard Medical School
Co-authored papers 2
Brian M Feldman
Co-authored papers 2
Douglas R Cavener
Co-authored papers 2
Aalim M Weljie
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 2
Steven E Schumacher
Co-authored papers 2
Rameen Beroukhim
Co-authored papers 2
Gao Zhang
Co-authored papers 2
Austin Dulak
Co-authored papers 2
Christopher Szeto
La Trobe Institute for Molecular Science, La Trobe University
Co-authored papers 2
Frederique Zindy
St. Jude Children's Research Hospital
Co-authored papers 2
Jayanta Debnath
University of California San Francisco
Co-authored papers 2
John M Kirkwood
UPMC Hillman Cancer Center
Co-authored papers 2
Philipp Mertins
Co-authored papers 2
Norman E Sharpless
National Cancer Institute
Co-authored papers 2
Steven A Carr
Broad Institute of MIT and Harvard
Co-authored papers 2
Andrew V Kossenkov
The Wistar Institute
Co-authored papers 2
Gary Hardiman
Institute for Global Food Security, Queen's University Belfast
Co-authored papers 2
Release 1.2