Author details

Full Name

Tony Pawson

Affiliation

ORCID

Career Start Year

1976

Papers

458

H Index

148

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
34848876	Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring.	Nature	2021
31974115	Multivalent nephrin-Nck interactions define a threshold for clustering and tyrosine-dependent nephrin endocytosis.	Journal of Cell Science	2020
32203420	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	Nat Cell Biol	2020
30996350	Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring.	Nature	2019
29440511	Structural basis for the interaction between the cell polarity proteins Par3 and Par6.	Science Signaling	2018
29930100	Interplay between ShcA Signaling and PGC-1Î± Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.	Cancer Res	2018
28276425	The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.	Nature Communications	2017
28964849	Grb2 regulates the proliferation of hematopoietic stem and progenitors cells.	Biochimica et Biophysica Acta - Molecular Cell Research	2017
29028184	Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition.	Elife	2017
26700805	SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination.	Nature	2016
26755559	Mutational Analysis of Glycogen Synthase Kinase 3Î² Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90.	Mol Cell Biol	2016
24837366	The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner.	Oncogene	2015
25752541	Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.	Structure	2015
25747659	Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles.	Mol Cell	2015
25829543	Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor.	Proc Natl Acad Sci U S A	2015
25531330	SYK interaction with ITGÎ²4 suppressed by Epstein-Barr virus LMP2A modulates migration and invasion of nasopharyngeal carcinoma cells.	Oncogene	2015
25299736	Albumin decrease is associated with spontaneous preterm delivery within 48 h in women with threatened preterm labor.	Journal of Proteome Research	2015
25852190	Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.	Sci Signal	2015
25948583	SELPHI: correlation-based identification of kinase-associated networks from global phospho-proteomics data sets.	Nucleic Acids Res	2015
26129894	A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.	Nat Commun	2015
25995205	Nck adaptor proteins modulate differentiation and effector function of T cells.	Journal of Leukocyte Biology	2015
26465210	Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.	Nature Communications	2015
26077966	Twisted amide electrophiles enable cyclic peptide sequencing.	Organic and Biomolecular Chemistry	2015
26332758	Selection of recombinant anti-SH3 domain antibodies by high-throughput phage display.	Protein Sci	2015
24658140	The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.	Nat Methods	2014
25331951	Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP.	J Biol Chem	2014
24412199	Incorporating DNA shearing in standard affinity purification allows simultaneous identification of both soluble and chromatin-bound interaction partners.	J Proteomics	2014
24270602	A quantitative liposome microarray to systematically characterize protein-lipid interactions.	Nat Methods	2014
24216761	Identification of a novel protein interaction motif in the regulatory subunit of casein kinase 2.	Molecular and Cellular Biology	2014
24450642	HDX-MS takes centre stage at unravelling kinase dynamics.	Biochemical Society Transactions	2014
24503186	CoreFlow: a computational platform for integration, analysis and modeling of complex biological data.	J Proteomics	2014
24550280	Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.	Proc Natl Acad Sci U S A	2014
24910098	Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation.	Molecular Cell	2014
25228766	Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation.	Proc Natl Acad Sci U S A	2014
23695548	The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.	Cancer Research	2013
23913047	Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.	Nature Immunology	2013
24162924	Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition.	Nat Methods	2013
24120531	Conserved Asf1-importin Î² physical interaction in growth and sexual development in the ciliate Tetrahymena thermophila.	J Proteomics	2013
24297922	Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling.	Proc Natl Acad Sci U S A	2013
24255178	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	Sci Signal	2013
23846654	Temporal regulation of EGF signalling networks by the scaffold protein Shc1.	Nature	2013
24296166	Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling.	Cold Spring Harbor perspectives in biology	2013
23921808	The CRAPome: a contaminant repository for affinity purification-mass spectrometry data.	Nat Methods	2013
23446150	Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells.	Journal of Leukocyte Biology	2013
23280595	Nck1 deficiency accelerates unloading-induced bone loss.	Journal of Cellular Physiology	2013
23401482	Rapid and sensitive MRM-based mass spectrometry approach for systematically exploring ganglioside-protein interactions.	Proteomics	2013
23277357	Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor Î² (TGFÎ²)-induced breast cancer cell migration, invasion, and metastasis.	Journal of Biological Chemistry	2013
23636498	Signalling change: signal transduction through the decades.	Nat Rev Mol Cell Biol	2013
23312284	Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis.		2013
23099349	Profiling the kinome: current capabilities and future challenges.	J Proteomics	2013