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Author Details

Donald C Lo
National Center for Advancing Translational Sciences
1990
93
44
PMIDPaper TitleJournal TitlePublished Year
35091700A call to action for translational sciences in COVID-19 and future pandemics.Nat Rev Drug Discov2022
33346633The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules.ACS Infect Dis2021
33623157Biological activity-based modeling identifies antiviral leads against SARS-CoV-2.Nat Biotechnol2021
33708112Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.Front Pharmacol2021
33689873Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection.Bioorg Med Chem Lett2021
34023496Drug combination therapy for emerging viral diseases.Drug Discov Today2021
32511355The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators.bioRxiv2020
32079652MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling.Genes Dev2020
32064048Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery.Oncotarget2020
32660307RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery.SLAS Discov2020
32766591Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2.bioRxiv2020
32839771Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.bioRxiv2020
32511420An OpenData portal to share COVID-19 drug repurposing data in real time.bioRxiv2020
30664937Induced pluripotent stem cells for neural drug discovery.Drug Discov Today2019
31420675Tumoricidal stem cell therapy enables killing in novel hybrid models of heterogeneous glioblastoma.Neuro Oncol2019
29576531Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells.Cell Chem Biol2018
29756681Neuronal IL-4Rα modulates neuronal apoptosis and cell viability during the acute phases of cerebral ischemia.FEBS J2018
28931805Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.Nat Commun2017
28194040Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.Nat Commun2017
28973132IKKβ and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD.Hum Mol Genet2017
29212711PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis.Sci Transl Med2017
28912778Neuroprotective Effects of Annexin A1 Tripeptide after Deep Hypothermic Circulatory Arrest in Rats.Front Immunol2017
28533375KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.Proc Natl Acad Sci U S A2017
27400126Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume.J Clin Invest2016
27789968Reduction of facial wrinkles by hydrolyzed water-soluble egg membrane associated with reduction of free radical stress and support of matrix production by dermal fibroblasts.Clin Cosmet Investig Dermatol2016
27732951IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance.Oncotarget2016
27751235Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.Elife2016
27427231SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.Cell Chem Biol2016
27172999Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.Sci Rep2016
25771168Differential roles of Aβ processing in hypoxia-induced axonal damage.Neurobiol Dis2015
25848045Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective.Proc Natl Acad Sci U S A2015
24431454BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin.J Neurosci2014
24592866Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.J Am Chem Soc2014
24706768Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition.Proc Natl Acad Sci U S A2014
23700210Experimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration.Neurotherapeutics2013
24130503Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke.PLoS Genet2013
23852340Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.Nat Med2013
21482444Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons.Neurobiol Aging2012
22998443Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.J Med Chem2012
22772050Targeting mutant huntingtin for the development of disease-modifying therapy.Drug Discov Today2012
22365609TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease.Chem Biol2012
21458569Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay.Neurobiol Dis2011
22128241Development of a low-pressure microtargeting biolistic device for transfection of retinal explants.Mol Vis2011
21832187A new kinetic framework for synaptic vesicle trafficking tested in synapsin knock-outs.J Neurosci2011
21950737In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models.J Neurochem2011
21304966Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1.PLoS One2011
20147317CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.Hum Mol Genet2010
21079601Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.Nat Chem Biol2010
21095569Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models.Chem Biol2010
20451607Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.Neurobiol Dis2010
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Collaborators

Brent R Stockwell
Columbia University
Co-authored papers 8
Anton Simeonov
Co-authored papers 8
Sam Michael
National Center for Advancing Translational Sciences, National Institutes of Health
Co-authored papers 6
Min Shen
National Center for Advancing Translational Sciences, National Institutes of Health
Co-authored papers 6
Bijal Shah
Moffitt Cancer Center
Co-authored papers 5
Nina Tang Sherwood
Duke University
Co-authored papers 4
Leslie M Thompson
Co-authored papers 3
Lisa M Ellerby
Buck Institute for Research on Aging
Co-authored papers 2
Christopher P Austin
St. George's University Medical School
Co-authored papers 2
David S Warner
Duke University Medical Center
Co-authored papers 2
Michael R Hayden
Co-authored papers 2
Stuart A Lipton
The Scripps Research Institute, University of California
Co-authored papers 1
Judit Pallos
Jungers Center for Neurosciences, Oregon Health and Science University
Co-authored papers 1
George B Mackensen
University of Washington
Co-authored papers 1
Guoping Feng
Co-authored papers 1
Ruth Luthi-Carter
University of Leicester
Co-authored papers 1
Brook T Wassie
Co-authored papers 1
Marc Ferrer
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Tom Mikkelsen
Ontario Brain Institute
Co-authored papers 1
Judith Frydman
Stanford University
Co-authored papers 1
David E Housman
Co-authored papers 1
William A Weiss
University of California san francisco
Co-authored papers 1
Ana Maria Cuervo
Albert Einstein College of Medicine
Co-authored papers 1
Clary B Clish
Broad Institute of MIT and Harvard
Co-authored papers 1
Ryan G Lim
Co-authored papers 1
Matthew Might
Hugh Kaul Precision Medicine Institute, University of Alabama at Birmingham
Co-authored papers 1
Joshua M Korn
Co-authored papers 1
Eliezer Masliah
National Institute On Aging
Co-authored papers 1
Joseph P Mathew
Duke University School of Medicine
Co-authored papers 1
Laura L??pez-Mascaraque
Instituto Cajal -CSIC-, Spanish National Research Council
Co-authored papers 1
Release 1.2