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Author Details

Rainer Kuhn
Novartis Pharma AG
1988
114
59
PMIDPaper TitleJournal TitlePublished Year
30150378Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition.Proc Natl Acad Sci U S A2018
27983565LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington's Disease.J Huntingtons Dis2016
25844897Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients.J Clin Invest2015
25316499AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: identification, SAR and pharmacological characterization.Bioorg Med Chem2014
25464275Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy.PLoS One2014
23861892Atg4b-dependent autophagic flux alleviates Huntington's disease progression.PLoS One2013
22984513Fragments of HdhQ150 mutant huntingtin form a soluble oligomer pool that declines with aggregate deposition upon aging.PLoS One2012
22996692Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression.J Clin Invest2012
21828077LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.Hum Mol Genet2011
21278900Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease.PLoS Curr2010
21156064Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors.Mol Neurodegener2010
17350267Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.Bioorg Med Chem2007
16329038Immunocytochemical localization of metabotropic (mGluR2/3 and mGluR4a) and ionotropic (GluR2/3) glutamate receptors in adrenal medullary ganglion cells.Histol Histopathol2006
15730868Immunoreactivity for the group III receptor subtype mGluR4a in the visual layers of the rat superior colliculus.Neuroscience2005
16339898A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo.Proc Natl Acad Sci U S A2005
14573382(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.Neuropharmacology2003
11814808[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.Bioorg Med Chem Lett2002
12373539In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: review article.Amino Acids2002
11923431Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia.J Neurosci2002
11786307Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives.Curr Opin Pharmacol2002
11821022Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).Eur J Pharmacol2002
11077065Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.Neuropharmacology2001
11264235Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist.Br J Pharmacol2001
11347975Discovery and characterization of non-competitive antagonists of group I metabotropic glutamate receptors.Farmaco2001
11328342An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors.Eur J Neurosci2001
11720869Design, synthesis and preliminary evaluation of novel 3'-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors.Bioorg Med Chem Lett2001
11698585Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7.J Neurosci2001
11445180The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats.Neuropharmacology2001
11431019Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders.Trends Pharmacol Sci2001
11169479Immunoreactivity for the group III metabotropic glutamate receptor subtype mGluR4a in the superficial laminae of the rat spinal dorsal horn.J Comp Neurol2001
11160389C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors.J Neurosci2001
11077066mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia.Neuropharmacology2001
10632098Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability.Ann Neurol2000
10866390(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist.Bioorg Med Chem Lett2000
10999540Loss of hilar mossy cells in Ammon's horn sclerosis.Epilepsia2000
10900022gamma-aminobutyric acid type B receptors are expressed and functional in mammalian cardiomyocytes.Proc Natl Acad Sci U S A2000
10850633Relaxation of human ureteral smooth muscle in vitro by modulation of cyclic nucleotide-dependent pathways.Urol Res2000
10844118Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice.Eur J Pharmacol2000
10934211The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors.J Biol Chem2000
10888329Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III.Bioorg Med Chem Lett2000
10974306Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective.Neuropharmacology2000
10924689Metabotropic glutamate receptor subtypes are differentially expressed after transient cerebral ischemia without, during and after tolerance induction in the gerbil hippocampus.Brain Res2000
10964947Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death.J Neurosci2000
11087567Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester.J Med Chem2000
11040347Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats.Eur J Pharmacol2000
11082464Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents.J Pharmacol Exp Ther2000
10744030Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients.J Neuropathol Exp Neurol2000
10693964Immunolocalization of the mGluR1b splice variant of the metabotropic glutamate receptor 1 at parallel fiber-Purkinje cell synapses in the rat cerebellar cortex.J Neurochem2000
10683602Immunocytochemical localization of the metabotropic glutamate receptor mGluR4a in the piriform cortex of the rat.J Comp Neurol2000
10555166Clustering of the group III metabotropic glutamate receptor 4a at parallel fiber synaptic terminals in the rat cerebellar molecular layer.Neurosci Res1999
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Collaborators

Salk Institute for Biological Studies
Co-authored papers 14
University of California, University of California Irvine
Co-authored papers 10
David Geffen School of Medicine, University of California-Los Angeles
Co-authored papers 4
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Co-authored papers 2
Matrahaza University and Teaching Hospital
Co-authored papers 2
University of Alabama at Birmingham
Co-authored papers 1
The Ludwig Institute for Cancer Research
Co-authored papers 1
Co-authored papers 1
American Association for Cancer Research, Henry Ford Hospital, Ludwig Institute for Cancer Research, National Cancer Institute, Salk Institute for Biological Studies, University of Cambridge, University of Texas MD Anderson Cancer Center, Virginia Commonwealth University
Co-authored papers 1
The Hospital for Sick Children
Co-authored papers 1
University of Rochester Medical Center
Co-authored papers 1
Department of Pharmaceutical Sciences, University of Perugia
Co-authored papers 1
The University of Hong Kong
Co-authored papers 1
University of Brescia
Co-authored papers 1
Baylor College of Medicine
Co-authored papers 1
University College Cork
Co-authored papers 1