Author details

Full Name

Rong Wang

Affiliation

ORCID

Career Start Year

1991

Papers

106

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36608337	Discovery of Highly Selective Inhibitors of the Human Constitutive Proteasome Î²5c Chymotryptic Subunit.		2023
37148884	Dual-pharmacophore artezomibs hijack the PlasmodiumÂ ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance.		2023
36130284	The transcriptional coactivator Eya1 exerts transcriptional repressive activity by interacting with REST corepressors and REST-binding sequences to maintain nephron progenitor identity.	Nucleic Acids Research	2022
35893133	Heterologous Expressed NbSWP12 from Microsporidia Can Bind with Phosphatidylinositol 3-Phosphate and Affect Vesicle Genesis.	Journal of Fungi	2022
33095579	Structure-Activity Relationships of Noncovalent Immunoproteasome Î²5i-Selective Dipeptides.	J Med Chem	2020
31177777	Improvement of Asparagine Ethylenediamines as Anti-malarial <i>Plasmodium</i>-Selective Proteasome Inhibitors.	J Med Chem	2019
29967165	Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.	Proc Natl Acad Sci U S A	2018
27976853	Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.	Biochemistry	2017
28889977	Novel Organelles with Elements of Bacterial and Eukaryotic Secretion Systems Weaponize Parasites of Drosophila.	Current Biology	2017
29093025	Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1.	Molecular Biology of the Cell	2017
27649271	Transmembrane Substrate Determinants for Î³-Secretase Processing of APP CTFÎ².	Biochemistry	2016
27466366	Characterization of Gonadotrope Secretoproteome Identifies Neurosecretory Protein VGF-derived Peptide Suppression of Follicle-stimulating Hormone Gene Expression.	J Biol Chem	2016
27956634	Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.	Proc Natl Acad Sci U S A	2016
26362155	Simultaneous quantification of labeled (2)H5-glycerol, (13)C6-glucose, and endogenous D-glucose in mouse plasma using liquid chromatography tandem mass spectrometry.	Analytical and Bioanalytical Chemistry	2015
25723488	Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates.	PLoS Genetics	2015
26526723	Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming.	Cell Stem Cell	2015
25209273	Differential release of Î²-amyloid from dendrite- versus axon-targeted APP.	Journal of Neuroscience	2014
25352592	A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of Î³-secretase.	J Biol Chem	2014
24401146	Soluble Î³-secretase modulators selectively inhibit the production of the 42-amino acid amyloid Î² peptide variant and augment the production of multiple carboxy-truncated amyloid Î² species.	Biochemistry	2014
25231164	Dystonia type 6 gene product Thap1: identification of a 50Â kDa DNA-binding species in neuronal nuclear fractions.	Acta Neuropathol Commun	2014
24658151	Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration.	PLoS ONE	2014
23720780	Anthrax SET protein: a potential virulence determinant that epigenetically represses NF-ÎºB activation in infected macrophages.	Journal of Biological Chemistry	2013
22850627	Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.	Mol Psychiatry	2013
22869031	Latrepirdine stimulates autophagy and reduces accumulation of Î±-synuclein in cells and in mouse brain.	Mol Psychiatry	2013
23550703	Global analysis of phosphorylation of tau by the checkpoint kinases Chk1 and Chk2 in vitro.	Journal of Proteome Research	2013
23205187	Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa.	ACS Chem Neurosci	2012
22593050	Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element.	J Neurosci	2012
22586122	Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of Î³-secretase using synthetic antibodies.	Proc Natl Acad Sci U S A	2012
22514632	MLN64 transport to the late endosome is regulated by binding to 14-3-3 via a non-canonical binding site.	PLoS ONE	2012
20406818	Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production.	J Biol Chem	2010
20849527	Î³-protocadherins are enriched and transported in specialized vesicles associated with the secretory pathway in neurons.	European Journal of Neuroscience	2010
20693289	Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.	J Biol Chem	2010
18681838	Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment.	Biology of the Cell	2009
19562802	Systems approach to explore components and interactions in the presynapse.	Proteomics	2009
19151997	Mass spectrometric analysis reveals a functionally important PKA phosphorylation site in a Kir3 channel subunit.	Pflugers Archiv European Journal of Physiology	2009
19906985	Modulation of gamma-secretase specificity using small molecule allosteric inhibitors.	Proc Natl Acad Sci U S A	2009
18539594	Direct and potent regulation of gamma-secretase by its lipid microenvironment.	Journal of Biological Chemistry	2008
17222479	Degradation of fibrillar forms of Alzheimer's amyloid beta-peptide by macrophages.	Neurobiology of Aging	2008
18602473	Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin.	Neurobiology of Disease	2008
18498745	The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation.	Mol Cell	2008
18218727	High-mobility group box proteins modulate tumor necrosis factor-alpha expression in osteoclastogenesis via a novel deoxyribonucleic acid sequence.	Molecular Endocrinology	2008
17028301	Morphine administration alters the profile of hippocampal postsynaptic density-associated proteins: a proteomics study focusing on endocytic proteins.	Mol Cell Proteomics	2007
17428795	Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor.	Journal of Biological Chemistry	2007
18003834	E2F1 works as a cell cycle suppressor in mature neurons.	Journal of Neuroscience	2007
17097615	MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins.	Biochemical and Biophysical Research Communications	2006
16752394	Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.	Human Mutation	2006
16603186	Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase.	Journal of Molecular Biology	2006
16230382	Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation.	Cancer Res	2005
16039562	Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.	Neuron	2005
15764596	Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.	J Biol Chem	2005