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Author Details

Fran??ois Van Laethem
National Cancer Institute, National Institutes of Health
1997
34
23
PMIDPaper TitleJournal TitlePublished Year
35911724MHC-independent αβT cells: Lessons learned about thymic selection and MHC-restriction.Front Immunol2022
36555775LAIR1, an ITIM-Containing Receptor Involved in Immune Disorders and in Hematological Neoplasms.Int J Mol Sci2022
34503088Clinical and Product Features Associated with Outcome of DLBCL Patients to CD19-Targeted CAR T-Cell Therapy.Cancers (Basel)2021
32321756Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155.J Immunol2020
32814051Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation.Cell Rep2020
32612609Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus.Front Immunol2020
30523076Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury.Science2019
30833553Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire.Nat Commun2019
28731407T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences.Elife2017
26301566TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells.Nat Immunol2015
24939536[Crucial role of CD4 and CD8 coreceptors in antigen recognition of αβT lymphocytes].Med Sci (Paris)2014
25161318T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1.Sci Signal2014
24034254Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.Cell2013
22036949Coreceptor gene imprinting governs thymocyte lineage fate.EMBO J2012
22771139MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection.Trends Immunol2012
22544394Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.Nat Immunol2012
22209676αβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities.Immunity2012
22403258Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.Blood2012
19747858Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.Immunity2009
18981117Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic.J Immunol2008
17702861Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.Proc Natl Acad Sci U S A2007
18023370Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.Immunity2007
17082573Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.J Immunol2006
16039581Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.Immunity2005
15965469Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.Nat Cell Biol2005
12626544Glucocorticoids alter the lipid and protein composition of membrane rafts of a murine T cell hybridoma.J Immunol2003
11777991Monophosphoryl lipid A activates both human dendritic cells and T cells.J Immunol2002
12243248Membrane lipid rafts: new targets for immunoregulation.Curr Mol Med2002
11090657Dexamethasone increases intracellular cyclic AMP concentration in murine T lymphocyte cell lines.Steroids2001
11283153Glucocorticoids attenuate T cell receptor signaling.J Exp Med2001
11706987A novel aspect of the anti-inflammatory actions of glucocorticoids: inhibition of proximal steps of signaling cascades in lymphocytes.Cell Mol Life Sci2001
10570279Antigen-experienced T cells undergo a transient phase of unresponsiveness following optimal stimulation.J Immunol1999
10426321Azodicarbonamide inhibits T-cell responses in vitro and in vivo.Nat Med1999
9334370Negative regulation of Fc epsilon RI-mediated degranulation by CD81.J Exp Med1997
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Collaborators

Lionel Feigenbaum
Science Applications International Corporation/Frederick
Co-authored papers 8
Eric Shifrut
Gladstone-UCSF Institute of Genomic Immunology
Co-authored papers 2
Nir Friedman
Weizmann Institute of Science
Co-authored papers 2
Nicolas Bouladoux
National Institute of Allergy and Infectious Diseases
Co-authored papers 1
Yongping Yang
Co-authored papers 1
Shurjo K Sen
Louisiana State University
Co-authored papers 1
Chen Yao
University of Texas Southwestern Medical Center
Co-authored papers 1
Allyson L Byrd
Genentech Inc.
Co-authored papers 1
Han-Yu Shih
National Eye Institute, National Institutes of Health
Co-authored papers 1
John J O'Shea
National Institute of Arthritis, National Institutes of Health
Co-authored papers 1
Asaf Madi
Co-authored papers 1
Marta Gut
Universitat de Barcelona (UB)
Co-authored papers 1
Seong-Ji Han
National Institute of Allergy and Infectious Diseases
Co-authored papers 1
Jonathan L Linehan
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 1
Nicholas Collins
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 1
Andrea Paun
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 1
Romain Fenouil
Universite de Toulon, CNRS
Co-authored papers 1
Rosalba Salcedo
Center for Cancer Research, National Cancer Institute
Co-authored papers 1
Charlotte Hurabielle
University of California san francisco
Co-authored papers 1
Samira Tamoutounour
National Institute of Allergy and Infectious Diseases
Co-authored papers 1
Michel Enamorado
National Institute of Allergy and Infectious Diseases
Co-authored papers 1
Oliver J Harrison
University Hospital Southampton
Co-authored papers 1
Ivo Gut
Spain Universitat de Barcelona (UB)
Co-authored papers 1
Margery Smelkinson
National Institute of Allergy and Infectious Diseases.
Co-authored papers 1
Yasmine Belkaid
National Institute of Allergy and Infectious Diseases
Co-authored papers 1
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