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Author Details

Qiang Zhou
The University of Hong Kong
1989
77
46
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36513571Reprogramming transcription after DNA damage: recognition, response, repair, and restart.Trends Cell Biol2023
37540094Quantitative Proteomics of the CDK9 Interactome Reveals a Function of the HSP90-CDC37-P-TEFb Complex for BETi-Induced HIV-1 Latency Reactivation.J Proteome Res2023
37016511Isobaric Stable Isotope N-Phosphorylation Labeling (iSIPL) for Ultrasensitive Proteome Quantification.Angew Chem Int Ed Engl2023
35393539Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage.Nat Cell Biol2022
35072011A natural product targets BRD4 to inhibit phase separation and gene transcription.iScience2021
32479599Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2.Nucleic Acids Res2020
32048991JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes.Elife2020
32818062Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence.Cell Discov2020
32520633HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer.Mol Biol Cell2020
32203417Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression.Nat Cell Biol2020
30663929Balanced between order and disorder: a new phase in transcription elongation control and beyond.Transcription2019
30864669A complex between DYRK1A and DCAF7 phosphorylates the C-terminal domain of RNA polymerase II to promote myogenesis.Nucleic Acids Res2019
30645648Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency.PLoS Pathog2019
29654614Quercetin protects against chronic prostatitis in rat model through NF-κB and MAPK signaling pathways.Prostate2018
29849146Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II.Nature2018
29949759The PARP1-Siah1 Axis Controls HIV-1 Transcription and Expression of Siah1 Substrates.Cell Rep2018
29684085The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency.PLoS Pathog2018
28878233A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter.Sci Rep2017
28134250Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription.Nat Commun2017
26830226A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency.Mol Cell Biol2016
27731797Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.Elife2016
27558685Pseudouridylation of 7SK snRNA promotes 7SK snRNP formation to suppress HIV-1 transcription and escape from latency.EMBO Rep2016
26007649Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription.Nucleic Acids Res2015
26569506A Natural Product from Polygonum cuspidatum Sieb. Et Zucc. Promotes Tat-Dependent HIV Latency Reversal through Triggering P-TEFb's Release from 7SK snRNP.PLoS One2015
26186095Correction: Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism.Elife2015
24367103AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.Proc Natl Acad Sci U S A2014
25053741LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.Elife2014
24843025AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter.Elife2014
24719417Kaposi's sarcoma-associated herpesvirus ORF45 mediates transcriptional activation of the HIV-1 long terminal repeat via RSK2.J Virol2014
23087374The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation.Nucleic Acids Res2013
23795863Viral-host interactions that control HIV-1 transcriptional elongation.Chem Rev2013
23471103The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat.Elife2013
23251033HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold.Proc Natl Acad Sci U S A2013
22404626RNA polymerase II elongation control.Annu Rev Biochem2012
22483617The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription.Mol Cell2012
22253435Mutual information analysis reveals coevolving residues in Tat that compensate for two distinct functions in HIV-1 gene expression.J Biol Chem2012
20385240Isolation and functional characterization of P-TEFb-associated factors that control general and HIV-1 transcriptional elongation.Methods2011
22100159The control of HIV transcription: keeping RNA polymerase II on track.Cell Host Microbe2011
21873227Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin.Proc Natl Acad Sci U S A2011
21360054New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).J Neuroimmune Pharmacol2011
20708689Purification and characterization of HIV-human protein complexes.Methods2011
19906723A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP.Nucleic Acids Res2010
20471948HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.Mol Cell2010
18079413Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor.Circ Res2008
18483222PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.Genes Dev2008
18249148A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.Mol Cell2008
18039861Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression.Mol Cell Biol2008
17341462Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription.Nucleic Acids Res2007
16980611Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation.Mol Cell Biol2006
17381310Regulation of two key nuclear enzymatic activities by the 7SK small nuclear RNA.Cold Spring Harb Symp Quant Biol2006
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Collaborators

Yuhua Xue
School of Pharmaceutical Sciences, Xiamen University
Co-authored papers 18
Huasong Lu
Life Sciences Institute, Zhejiang University
Co-authored papers 17
Nanhai He
Adlai Nortye USA Inc.
Co-authored papers 10
Zichong Li
Gladstone Center for HIV Cure Research, Gladstone Institute of Virology
Co-authored papers 9
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Gladstone Institute of Virology and Immunology
Co-authored papers 7
Tom Alber
University of California berkeley
Co-authored papers 7
Ursula Schulze-Gahmen
Gladstone Institute of Virology, Gladstone Institutes San Francisco CA USA .
Co-authored papers 7
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 5
Seemay Chou
University of California - San Francisco
Co-authored papers 5
Min Liu
Xiamen University
Co-authored papers 5
Goran Stjepanovic
Kobilka Institute of Innovative Drug Discovery, The Chinese University of Hong Kong
Co-authored papers 2
Joanne H Hsu
Clinical Research Division, Fred Hutchinson Cancer Research Center
Co-authored papers 2
James H Hurley
University of California Berkeley
Co-authored papers 2
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UC Berkeley
Co-authored papers 2
Katherine Bao
Duke University Medical Center
Co-authored papers 2
Heather E Upton
University of California berkeley
Co-authored papers 2
Kai Zhang
University of California
Co-authored papers 1
Anders S Hansen
Co-authored papers 1
Nadine Czudnochowski
University of California san francisco
Co-authored papers 1
Iv??n D'Orso
University of Texas Southwestern Medical Center
Co-authored papers 1
Moon Kyoo Jang
Co-authored papers 1
Gregory D Friedland
Joint BioEnergy Institute
Co-authored papers 1
Avi J Samelson
Institute for Neurodegenerative Diseases, University of California san francisco
Co-authored papers 1
Natali Gulbahce
Complete Genomics Inc.
Co-authored papers 1
David V Schaffer
University of California berkeley
Co-authored papers 1
Kirk C Hansen
University of Colorado Anschutz Medical Campus
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Satish K Pillai
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