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Author Details

Jeremy M Simon
University of North Carolina
2010
72
26
Nathan Sheffield (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36202274Short-term transcriptomic changes in the mouse neural tube induced by an acute alcohol exposure.Alcohol2023
37819053RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy.Elife2023
37599994Environmental carcinogens disproportionally mutate genes implicated in neurodevelopmental disorders.Front Neurosci2023
37389991Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice.Cell Rep2023
37416481An EZH2-NF-κB regulatory axis drives expression of pro-oncogenic gene signatures in triple negative breast cancer.iScience2023
36857457Distinct roles for canonical and variant histone H3 lysine-36 in Polycomb silencing.Sci Adv2023
36445063STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity.Adv Sci (Weinh)2023
35302756Bioorthogonal Chemical Epigenetic Modifiers Enable Dose-Dependent CRISPR Targeted Gene Activation in Mammalian Cells.ACS Synth Biol2022
35401533BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis.Front Immunol2022
35577980TP53, CDKN2A/P16, and NFE2L2/NRF2 regulate the incidence of pure- and combined-small cell lung cancer in mice.Oncogene2022
35764091An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma.Mol Cell2022
35535852Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of <i>Tcf4</i> expression.Elife2022
35396933The pro-apoptotic Bax gene modifies susceptibility to craniofacial dysmorphology following gastrulation-stage alcohol exposure.Birth Defects Res2022
35365720Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model.Sci Rep2022
35618754Author Correction: scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy.Nat Commun2022
36590168Depletion of HIV reservoir by activation of ISR signaling in resting CD4<sup>+</sup>T cells.iScience2022
36002660Correction: TP53, CDKN2A/P16, and NFE2L2/NRF2 regulate the incidence of pure- and combined-small cell lung cancer in mice.Oncogene2022
36037364USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer.Proc Natl Acad Sci U S A2022
35013001PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner.Cancer Immunol Res2022
33326110Epigenetic Analysis in Ewing Sarcoma.Methods Mol Biol2021
33826889MicroRNA-29 is an essential regulator of brain maturation through regulation of CH methylation.Cell Rep2021
33706927The essential role of primary cilia in cerebral cortical development and disorders.Curr Top Dev Biol2021
33667343Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury.Neuron2021
34676830Dual-isoform hUBE3A gene transfer improves behavioral and seizure outcomes in Angelman syndrome model mice.JCI Insight2021
33964984Correction to: Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life.Mol Autism2021
34137816Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol.Dis Model Mech2021
32557641Transcriptome-Wide Regulation of Key Developmental Pathways in the Mouse Neural Tube by Prenatal Alcohol Exposure.Alcohol Clin Exp Res2020
31961859Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation.PLoS Genet2020
32023483Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss.Mol Cell2020
32015540A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder.Nat Neurosci2020
33172406A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance.J Neurodev Disord2020
33087932Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA.Nature2020
32690540Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer.Cancer Discov2020
32619021A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue.J Pathol2020
33023670Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life.Mol Autism2020
32521276Unique and Shared Roles for Histone H3K36 Methylation States in Transcription Regulation Functions.Cell Rep2020
32327659Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration.Nat Commun2020
32461361USP37 promotes deubiquitination of HIF2α in kidney cancer.Proc Natl Acad Sci U S A2020
32490353Putative modulation of the gut microbiome by probiotics enhances preference for novelty in a preliminary double-blind placebo-controlled study in ferrets.Anim Microbiome2020
30635555Single-cell transcriptomic analysis of mouse neocortical development.Nat Commun2019
31729379Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer.Nat Commun2019
31863004scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy.Nat Commun2019
30872602High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq.Sci Rep2019
27742763Molecular classification of Crohn's disease reveals two clinically relevant subtypes.Gut2018
30026228VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.Science2018
29429127Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription.Mamm Genome2018
28931574Enhanced Nociception in Angelman Syndrome Model Mice.J Neurosci2017
28379424Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma.Neuro Oncol2017
28398584Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma.Neuro Oncol2017
29038090Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice.Environ Health Perspect2017
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Collaborators

Jason D Lieb
The University of Chicago
Co-authored papers 11
Terrence S Furey
University of North Carolina at Chapel Hill
Co-authored papers 9
Joel S Parker
Lineberger Cancer Center, University of North Carolina
Co-authored papers 5
Gregory E Crawford
Center for Genomic & Computational Biology, Duke University
Co-authored papers 5
Michael B Major
Washington University in St. Louis
Co-authored papers 5
Alexias Safi
Center for Genomic and Computational Biology, Duke University Medical Center
Co-authored papers 4
Cheng Fan
Co-authored papers 4
David Neil Hayes
Center for Cancer Research, University of Tennessee Health Science Center
Co-authored papers 4
Paul G Giresi
Center for Personal Dynamic Regulomes
Co-authored papers 4
Ivan Rusyn
Co-authored papers 3
Charles M Perou
Co-authored papers 3
Laura E Herring
Co-authored papers 3
Ryan E Bash
University of Alabama School of Medicine
Co-authored papers 3
Stephanie A Montgomery
and Lineberger Comprehensive Cancer Center, University of North Carolina System
Co-authored papers 3
Ryan Balfour Sartor
University of North Carolina at Chapel Hill
Co-authored papers 3
Christopher Ryan Miller
University of Illinois at Urbana-Champaign
Co-authored papers 3
Scott H Randell
Co-authored papers 3
Norman E Sharpless
National Cancer Institute
Co-authored papers 3
Bum-Kyu Lee
Cancer Research Center, University at Albany, State University of New York
Co-authored papers 2
Kyle S Smith
St. Jude Children's Research Hospital
Co-authored papers 2
Rajeev Vibhakar
Center for Cancer and Blood Disorders, Children's Hospital Colorado.
Co-authored papers 2
Mark Vitucci
Co-authored papers 2
Lingyun Song
Center for Genomic & Computational Biology, Duke University
Co-authored papers 2
Kirk C Wilhelmsen
West Virginia University
Co-authored papers 2
Zhancheng Zhang
Co-authored papers 2
Michael E Berens
Co-authored papers 2
Brian D Strahl
University of North Carolina
Co-authored papers 2
Karen L Mohlke
Co-authored papers 2
Ling Xie
Co-authored papers 2
Nathan Sheffield (CM4AI)
University of Virginia
Co-authored papers 2
Release 1.2