Author details

Full Name

Douglas R Cavener

Affiliation

ORCID

Career Start Year

1976

Papers

104

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37313272	Genetic evidence of population subdivision among Masai giraffes separated by the Gregory Rift Valley in Tanzania.		2023
33879538	Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B Demyelinating Neuropathy.	Journal of Neuroscience	2021
33892188	Co-opting regulation bypass repair as a gene-correction strategy for monogenic diseases.	Molecular Therapy	2021
33144949	Genetic connectivity and population structure of African savanna elephants () in Tanzania.	Ecology and Evolution	2020
32324833	Ribosome binding protein GCN1Â regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.	PLoS Genet	2020
29444822	The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.	Journal of Biological Chemistry	2018
30310743	Seeing spots: quantifying mother-offspring similarity and assessing fitness consequences of coat pattern traits in a wild population of giraffes ().	PeerJ	2018
28396824	Evolutionary analysis of vision genes identifies potential drivers of visual differences between giraffe and okapi.	PeerJ	2017
28332979	The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration.	eLife	2017
27716400	PERK regulates G protein-coupled intracellular Ca dynamics in primary cortical neurons.	Molecular Brain	2016
27103515	Repression of the eIF2Î± kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease.	Neurobiology of Aging	2016
27187213	Giraffe genome sequence reveals clues to its unique morphology and physiology.	Nat Commun	2016
27807175	Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse.	Journal of Neuroscience	2016
27627766	PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility.	PLoS ONE	2016
24958502	Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling.	Hypertension	2014
24481666	Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination.	GLIA	2014
24915520	Perk gene dosage regulates glucose homeostasis by modulating pancreatic Î²-cell functions.	PLoS ONE	2014
24741110	The eIF2Î± kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression.	Learning and Memory	2014
24130751	GCN2 in the brain programs PPARÎ³2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat.	PLoS ONE	2013
24114838	Insulin secretion and Ca2+ dynamics in Î²-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.	Journal of Biological Chemistry	2013
23900421	GCN2 regulates the CCAAT enhancer binding protein beta and hepatic gluconeogenesis.	American Journal of Physiology - Endocrinology and Metabolism	2013
24189069	25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.	J Biol Chem	2013
23933749	Suppression of eIF2Î± kinases alleviates Alzheimer's disease-related plasticity and memory deficits.	Nature Neuroscience	2013
22813743	Brain-specific disruption of the eIF2Î± kinase PERK decreases ATF4 expression and impairs behavioral flexibility.	Cell Reports	2012
21876766	Hyperthermia induces the ER stress pathway.	PLoS ONE	2011
21135100	Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2.	Journal of Biological Chemistry	2011
20453876	PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage.	Oncogene	2010
20850340	PERK in beta cell biology and insulin biogenesis.	Trends in Endocrinology and Metabolism	2010
20530744	PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.		2010
19956728	PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice.	PLoS ONE	2009
19732428	Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation.	BMC Cell Biology	2009
19114729	Sleeping Beauty, awake! Regulation of insulin gene expression by methylation of histone H3.		2009
19509078	eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver.	Physiological Genomics	2009
19783659	GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.	Journal of Biological Chemistry	2009
18683826	PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation.	Journal of Cellular Physiology	2008
18070882	Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis.	Journal of Biological Chemistry	2008
18852460	PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation.	Proc Natl Acad Sci U S A	2008
17727724	PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice.	BMC Cell Biology	2007
17276353	The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.	Cell Metabolism	2007
17498303	Expansion and evolution of insect GMC oxidoreductases.	BMC Evolutionary Biology	2007
17760508	Translational control and the unfolded protein response.	Antioxidants and Redox Signaling	2007
16709834	The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells.	J Immunol	2006
16124869	PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis.	Biochemical Journal	2006
17157218	Tryptophan catabolism generates autoimmune-preventive regulatory T cells.	Transpl Immunol	2006
17141632	PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.	Cell Metabolism	2006
16715098	Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.	Nature Genetics	2006
16000157	PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia.	Journal of Neurochemistry	2005
15774759	Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.	Science	2005
15705595	Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum.	Journal of Biological Chemistry	2005
15213227	Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.	Journal of Biological Chemistry	2004