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Author Details

Stefan W??lfl
Institute of Pharmacy and Molecular Biotechnology, Heidelberg University
1987
144
39
Kirsten Obernier (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36898000Elucidating the Multimodal Anticancer Mechanism of an Organometallic Terpyridine Platinum(II) N-Heterocyclic Carbene Complex against Triple-Negative Breast Cancer In Vitro and In Vivo.J Med Chem2023
37253308Development of a next-generation endogenous OCT4 inducer and its anti-aging effect in vivo.Eur J Med Chem2023
35304627Real-time monitoring of immediate drug response and adaptation upon repeated treatment in a microfluidic chip system.Arch Toxicol2022
35484422MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.Nat Cancer2022
36497120Cell Type-Specific Metabolic Response to Amino Acid Starvation Dictates the Role of Sestrin2 in Regulation of mTORC1.Cells2022
36496994Oxygen Gradient Induced in Microfluidic Chips Can Be Used as a Model for Liver Zonation.Cells2022
34860252pVHL-mediated SMAD3 degradation suppresses TGF-β signaling.J Cell Biol2022
33359260Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis.Free Radic Biol Med2021
33482908Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells.Cancer Metab2021
34008350Continuous optical in-line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality.Biotechnol J2021
32330875Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance.EBioMedicine2020
31909202NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice.Commun Biol2020
32529715A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT-116 Colorectal Carcinoma Cells.Angew Chem Int Ed Engl2020
30874583In vitro metabolic activation of vitamin D3 by using a multi-compartment microfluidic liver-kidney organ on chip platform.Sci Rep2019
31231607p53-Dependent Anti-Proliferative and Pro-Apoptotic Effects of a Gold(I) <i>N</i>-Heterocyclic Carbene (NHC) Complex in Colorectal Cancer Cells.Front Oncol2019
29352207Ethanol sensitizes hepatocytes for TGF-β-triggered apoptosis.Cell Death Dis2018
33418680Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites.ACS Biomater Sci Eng2018
30181873Activation of pro-survival metabolic networks by 1,25(OH)<sub>2</sub>D<sub>3</sub> does not hamper the sensitivity of breast cancer cells to chemotherapeutics.Cancer Metab2018
30176945Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.J Exp Clin Cancer Res2018
30006161Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction.Eur J Med Chem2018
30544880A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway.Int J Mol Sci2018
30511023Golgi stress mediates redox imbalance and ferroptosis in human cells.Commun Biol2018
30388963Correction to: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.J Exp Clin Cancer Res2018
29354647Guidelines and recommendations on yeast cell death nomenclature.Microb Cell2018
29534438Expression of TXNIP in Cancer Cells and Regulation by 1,25(OH)â¿¿Dâ¿¿: Is It Really the Vitamin Dâ¿¿ Upregulated Protein?Int J Mol Sci2018
29651101Author Correction: Essential role of mitochondrial Stat3 in p38<sup>MAPK</sup> mediated apoptosis under oxidative stress.Sci Rep2018
29209748Monitoring cytochrome P450 activity in living hepatocytes by chromogenic substrates in response to drug treatment or during cell maturation.Arch Toxicol2018
29095348Di (2-Ethylhexyl) Phthalate and Its Role in Developing Cholestasis: An In Vitro Study on Different Liver Cell Types.J Pediatr Gastroenterol Nutr2018
27884681Acidic stress induced G1 cell cycle arrest and intrinsic apoptotic pathway in Jurkat T-lymphocytes.Exp Cell Res2017
28357389Mutational analysis of fructose-1,6-bis-phosphatase FBP1 indicates partially independent functions in gluconeogenesis and sensitivity to genotoxic stress.Microb Cell2017
28155845Design and fabrication of a scalable liver-lobule-on-a-chip microphysiological platform.Biofabrication2017
28426762Human microRNA-299-3p decreases invasive behavior of cancer cells by downregulation of Oct4 expression and causes apoptosis.PLoS One2017
28124999Effects of 1,25(OH)â¿¿Dâ¿¿ on Cancer Cells and Potential Applications in Combination with Established and Putative Anti-Cancer Agents.Nutrients2017
29133922Essential role of mitochondrial Stat3 in p38<sup>MAPK</sup> mediated apoptosis under oxidative stress.Sci Rep2017
29048387Vitamin D as a Novel Regulator of Tumor Metabolism: Insights on Potential Mechanisms and Implications for Anti-Cancer Therapy.Int J Mol Sci2017
286519731,25(OH)<sub>2</sub>D<sub>3</sub> disrupts glucose metabolism in prostate cancer cells leading to a truncation of the TCA cycle and inhibition of TXNIP expression.Biochim Biophys Acta Mol Cell Res2017
28730310Optical biosensor optimized for continuous in-line glucose monitoring in animal cell culture.Anal Bioanal Chem2017
28618116Differences in p53 status significantly influence the cellular response and cell survival to 1,25-dihydroxyvitamin D3-metformin cotreatment in colorectal cancer cells.Mol Carcinog2017
28557430Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule.J Med Chem2017
26972255Modified STAP conditions facilitate bivalent fate decision between pluripotency and apoptosis in Jurkat T-lymphocytes.Biochem Biophys Res Commun2016
28006013Procarcinogens - Determination and Evaluation by Yeast-Based Biosensor Transformed with Plasmids Incorporating RAD54 Reporter Construct and Cytochrome P450 Genes.PLoS One2016
27334935A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action.Dalton Trans2016
27344203Multimodal Eph/Ephrin signaling controls several phases of urogenital development.Kidney Int2016
27313533Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts.Front Physiol2016
27306974BMP2 Transfer to Neighboring Cells and Activation of Signaling.Traffic2016
26887594Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs.Mol Oncol2016
26686930The new facile and straightforward method for the synthesis of 4H-1,2,3-thiadiazolo[5,4-b]indoles and determination of their antiproliferative activity.Eur J Med Chem2016
26850306Alkynyl gold(I) phosphane complexes: Evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex.J Inorg Biochem2016
25608481Vesicular disruption of lysosomal targeting organometallic polyarginine bioconjugates.Metallomics2015
26488607In Vitro Generation of Functional Liver Organoid-Like Structures Using Adult Human Cells.PLoS One2015
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Collaborators

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Co-authored papers 4
Institute of Neurophysiology, University of Cologne
Co-authored papers 1
Medical University of Vienna
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University of Augsburg
Co-authored papers 1
Saint Louis University School of Medicine
Co-authored papers 1
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Universitat Heidelberg
Co-authored papers 1
University of Maryland School of Medicine
Co-authored papers 1
Weizmann Institute of Science
Co-authored papers 1
Co-authored papers 1
Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg
Co-authored papers 1
Columbia University Medical Center
Co-authored papers 1
University of Zurich
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Research Centre, Ananda College
Co-authored papers 1
University Children's Hospital of Cologne
Co-authored papers 1
Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg
Co-authored papers 1
Universitat Heidelberg
Co-authored papers 1
Chalmers University of Technology
Co-authored papers 1
Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg
Co-authored papers 1
Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg
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University of Colorado School of Medicine
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Center for Molecular Imaging, University of Pittsburgh School of Medicine
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