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Author Details

Raymond C Stevens
iHuman Institute, ShanghaiTech University
1988
386
107
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36677809GLP-1R Signaling and Functional Molecules in Incretin Therapy.Molecules2023
36973264Structural insights into the human niacin receptor HCA2-G<sub>i</sub> signalling complex.Nat Commun2023
35093200A new visual design language for biological structures in a cell.Structure2022
35436726Aerobic glycolysis imaging of epileptic foci during the inter-ictal period.EBioMedicine2022
35817871Structural insight into apelin receptor-G protein stoichiometry.Nat Struct Mol Biol2022
35921440Quantitative, in situ visualization of intracellular insulin vesicles in pancreatic beta cells.Proc Natl Acad Sci U S A2022
35977382GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A<sub>2A</sub> Adenosine Receptor.J Med Chem2022
36048824An intensity-based post-processing tool for 3D instance segmentation of organelles in soft X-ray tomograms.PLoS One2022
33190475Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structureâ¿ .J Med Chem2021
33753204Assessment of scoring functions to rank the quality of 3D subtomogram clusters from cryo-electron tomography.J Struct Biol2021
34641297Pursuing High-Resolution Structures of Nicotinic Acetylcholine Receptors: Lessons Learned from Five Decades.Molecules2021
34453000Bayesian metamodeling of complex biological systems across varying representations.Proc Natl Acad Sci U S A2021
34477367Rational Remodeling of Atypical Scaffolds for the Design of Photoswitchable Cannabinoid Receptor Tools.J Med Chem2021
34012065Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes.Commun Biol2021
34254582Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor.Elife2021
32125824Correction to Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor.Anal Chem2020
31784719Small-scale approach for precrystallization screening in GPCR X-ray crystallography.Nat Protoc2020
31978323Biased Signaling of the G-Protein-Coupled Receptor β<sub>2</sub>AR Is Governed by Conformational Exchange Kinetics.Structure2020
33298443Visualizing subcellular rearrangements in intact β cells using soft x-ray tomography.Sci Adv2020
33298442Visualizing insulin vesicle neighborhoods in β cells by cryo-electron tomography.Sci Adv2020
33069069An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli.Bioorg Med Chem2020
33006884A Single Reactive Noncanonical Amino Acid is Able to Dramatically Stabilize Protein Structure.ACS Chem Biol2020
32152292Full-length human GLP-1 receptor structure without orthosteric ligands.Nat Commun2020
32327598Determination of the melanocortin-4 receptor structure identifies Ca<sup>2+</sup> as a cofactor for ligand binding.Science2020
32537509Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases.Sci Adv2020
30639103Crystal Structure of the Human Cannabinoid Receptor CB2.Cell2019
31807708Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.Sci Adv2019
31801061Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α<sub>2C</sub> Adrenergic Receptor.Cell Rep2019
31801060Structural Basis of the Diversity of Adrenergic Receptors.Cell Rep2019
31855179Common activation mechanism of class A GPCRs.Elife2019
30239054Emerging structural biology of lipid G protein-coupled receptors.Protein Sci2019
31181898A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure.ACS Chem Biol2019
31180094The structure-based traceless specific fluorescence labeling of the smoothened receptor.Org Biomol Chem2019
31515283Probing the CB<sub>1</sub> Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist.Mol Pharmacol2019
30744995De Novo Structural Pattern Mining in Cellular Electron Cryotomograms.Structure2019
30840872Advancing Chemokine GPCR Structure Based Drug Discovery.Structure2019
31094506Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor.Anal Chem2019
31038495The lipid phase preference of the adenosine A<sub>2A</sub> receptor depends on its ligand binding state.Chem Commun (Camb)2019
30733446Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.Nat Commun2019
31048811Publisher Correction: Structural basis of ligand recognition at the human MT1 melatonin receptor.Nature2019
31019306Structural basis of ligand recognition at the human MT<sub>1</sub> melatonin receptor.Nature2019
31019305XFEL structures of the human MT<sub>2</sub> melatonin receptor reveal the basis of subtype selectivity.Nature2019
30573766Publisher Correction: Crystal structure of misoprostol bound to the labor inducer prostaglandin E<sub>2</sub> receptor.Nat Chem Biol2019
30510194Crystal structure of misoprostol bound to the labor inducer prostaglandin E<sub>2</sub> receptor.Nat Chem Biol2019
30664776An online resource for GPCR structure determination and analysis.Nat Methods2019
29290469Allosteric Coupling of Drug Binding and Intracellular Signaling in the A<sub>2A</sub> Adenosine Receptor.Cell2018
30135577Crystal structure of the Frizzled 4 receptor in a ligand-free state.Nature2018
29808000Structural basis for signal recognition and transduction by platelet-activating-factor receptor.Nat Struct Mol Biol2018
30038283Author Correction: Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y<sub>1</sub> and P2Y<sub>12</sub> receptors.Sci Rep2018
29927385Computational design of thermostabilizing point mutations for G protein-coupled receptors.Elife2018
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Collaborators

Gye Won Han
Bridge Institute, University of Southern California
Co-authored papers 85
Peter Kuhn
University of Tubingen
Co-authored papers 68
Ian A Wilson
The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 54
Scott A Lesley
Merck & Co., Inc.
Co-authored papers 51
Lukasz Jaroszewski
University of California Riverside School of Medicine
Co-authored papers 48
Ashley M Deacon
Accelero Biostructures Inc., USA XPose Therapeutics Inc.
Co-authored papers 48
Heath E Klock
Merck & Co., Inc.
Co-authored papers 48
Daniel McMullan
Genomics Institute of the Novartis Research Foundation
Co-authored papers 47
Adam Godzik
University of California Riverside
Co-authored papers 47
John Wooley
University of California
Co-authored papers 47
Keith O Hodgson
Stanford University
Co-authored papers 47
Slawomir K Grzechnik
Co-authored papers 47
Marc-Andr?? Elsliger
Joint Center for Structural Genomics
Co-authored papers 47
Mitchell D Miller
Rice University
Co-authored papers 47
Henry van den Bedem
University of California San Francisco
Co-authored papers 46
Qingping Xu
Argonne National Laboratory
Co-authored papers 41
Andrew T Morse
Co-authored papers 35
Polat Abdubek
Regeneron Pharmaceuticals, Inc.
Co-authored papers 31
Hsiu-Ju Chiu
Joint Center for Structural Genomics
Co-authored papers 30
Ron Reyes
Co-authored papers 25
Linda S Brinen
The Joint Center for Structural Genomics, Stanford University
Co-authored papers 24
Bryan L Roth
UNC Chapel Hill School of Medicine
Co-authored papers 22
Suwen Zhao
ShanghaiTech University, China iHuman Institute
Co-authored papers 22
Kurt W??thrich
iHuman Institute, ShanghaiTech University
Co-authored papers 20
Aprilfawn White
Co-authored papers 19
Edward Nigoghossian
Genomics Institute of the Novartis Research Foundation
Co-authored papers 19
Kenneth A Jacobson
National Institutes of Health
Co-authored papers 18
Kate L White
Lawrence Berkeley National Laboratory
Co-authored papers 18
Jessica Paulsen
Co-authored papers 17
Herbert L Axelrod
Joint Center for Structural Genomics
Co-authored papers 15
Release 1.2