Author details

Full Name

Brian Button

Affiliation

ORCID

Career Start Year

1996

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37285404	Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration.		2023
35001665	Physiology and pathophysiology of human airway mucus.	Physiological Reviews	2022
35879412	Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.	Nat Genet	2022
35689870	Mucus-targeting therapies of defective mucus clearance for cystic fibrosis: A short review.	Current Opinion in Pharmacology	2022
35363522	Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis.	Science advances	2022
35356083	Regional Differences in Mucociliary Clearance in the Upper and Lower Airways.	Frontiers in Physiology	2022
34800616	A mucoadhesive biodissolvable thin film for localized and rapid delivery of lidocaine for the treatment of vestibulodynia.	Int J Pharm	2022
34064654	Airway Epithelial Nucleotide Release Contributes to Mucociliary Clearance.	Life	2021
32802823	Effect of hypertonic saline on mucociliary clearance and clinical outcomes in chronic bronchitis.	ERJ Open Research	2020
31800264	Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2020
31898911	TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis.	American Journal of Respiratory and Critical Care Medicine	2020
31120356	The Cystic Fibrosis-Like Airway Surface Layer Is not a Significant Barrier for Delivery of Eluforsen to Airway Epithelial Cells.	Journal of Aerosol Medicine and Pulmonary Drug Delivery	2019
31687423	Adhesive and Cohesive Peel Force Measurement of Human Airway Mucus.	Bio-protocol	2019
31524632	IL-1Î² dominates the promucin secretory cytokine profile in cystic fibrosis.	Journal of Clinical Investigation	2019
30712400	Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum.	COPD	2018
30361244	Pathological mucus and impaired mucus clearance in cystic fibrosis patients result from increased concentration, not altered pH.	European Respiratory Journal	2018
30420506	Roles of mucus adhesion and cohesion in cough clearance.	Proceedings of the National Academy of Sciences of the United States of America	2018
30282981	Mucociliary Clearance in Mice Measured by Tracking Trans-tracheal Fluorescence of Nasally Aerosolized Beads.	Scientific Reports	2018
29599187	The effect of nebulised hypertonic saline on human bronchial epithelium.	European Respiratory Journal	2018
29154907	An integrated mathematical epithelial cell model for airway surface liquid regulation by mechanical forces.	Journal of Theoretical Biology	2018
28062483	Sialic acid-to-urea ratio as a measure of airway surface hydration.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2017
29123085	Airway surface liquid pH is not acidic in children with cystic fibrosis.	Nature Communications	2017
27115951	Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype.	Annals of the American Thoracic Society	2016
26968767	Reduced mucociliary clearance in old mice is associated with a decrease in Muc5b mucin.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2016
25909230	The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis.	Am J Respir Crit Care Med	2015
24892808	Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure.	Journal of Clinical Investigation	2014
25267619	Probing biological nanotopology via diffusion of weakly constrained plasmonic nanorods with optical coherence tomography.	Proceedings of the National Academy of Sciences of the United States of America	2014
23415939	A mechanochemical model for auto-regulation of lung airway surface layer volume.	Journal of Theoretical Biology	2013
23757023	Mechanosensitive ATP release maintains proper mucus hydration of airways.	Science Signaling	2013
23751214	Structure and function of the mucus clearance system of the lung.	Cold Spring Harbor Perspectives in Medicine	2013
22003093	Transgenic hCFTR expression fails to correct Î²-ENaC mouse lung disease.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2012
22923574	A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia.	Science	2012
23024894	Monitoring airway mucus flow and ciliary activity with optical coherence tomography.	Biomedical Optics Express	2012
22259141	Establishment of respiratory air-liquid interface cultures and their use in studying mucin production, secretion, and function.	Methods in Molecular Biology	2012
21560044	Computational model for the regulation of extracellular ATP and adenosine in airway epithelia.	Sub-Cellular Biochemistry	2011
20566636	Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice.	Journal of Biological Chemistry	2010
20439165	Osmolytes and ion transport modulators: new strategies for airway surface rehydration.	Current Opinion in Pharmacology	2010
19621064	CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium.	PLoS Biol	2009
18585484	Role of mechanical stress in regulating airway surface hydration and mucus clearance rates.	Respiratory Physiology and Neurobiology	2008
18662982	Mathematical model of nucleotide regulation on airway epithelia. Implications for airway homeostasis.	Journal of Biological Chemistry	2008
17317749	Differential effects of cyclic and constant stress on ATP release and mucociliary transport by human airway epithelia.	Journal of Physiology	2007
16879250	Association between mannan-binding lectin and impaired lung function in cystic fibrosis may be age-dependent.	Clinical and Experimental Immunology	2006
16460283	Regulation of normal and cystic fibrosis airway surface liquid volume by phasic shear stress.	Annual Review of Physiology	2006
17116883	A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms.	Proceedings of the National Academy of Sciences of the United States of America	2006
16364874	Trends in lung pH and PO2 after circulatory arrest: implications for non-heart-beating donors and cell culture models of lung ischemia-reperfusion injury.	Journal of Heart and Lung Transplantation	2005
16087672	Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections.	J Biol Chem	2005
15463946	Measurements of airway surface liquid height and mucus transport by fluorescence microscopy, and of ion composition by X-ray microanalysis.	Journal of Cystic Fibrosis	2004
15282191	Potentiation of effect of PKA stimulation of Xenopus CFTR by activation of PKC: role of NBD2.	American Journal of Physiology - Cell Physiology	2004
11331356	PKC-mediated stimulation of amphibian CFTR depends on a single phosphorylation consensus site. insertion of this site confers PKC sensitivity to human CFTR.	Journal of General Physiology	2001
11236909	Quantitative assessment of a circulating depolarizing factor in shock.	Shock	2001