Author details

Full Name

Guillaume Lettre

Affiliation

ORCID

Career Start Year

2004

Papers

151

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37228746	Systematic elucidation of genetic mechanisms underlying cholesterol uptake.		2023
36226494	Variation and impact of polygenic hematologic traits in monogenic sickle cell disease.	Haematologica	2023
37732177	Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification.		2023
38077122	Gene-metabolite annotation with shortest reactional distance enhances metabolite genome-wide association studies results.		2023
37552626	Re-assessing the effect of fetal hemoglobin on stroke in the Cooperative Study of Sickle Cell Disease.		2023
36711952	Systematic elucidation of genetic mechanisms underlying cholesterol uptake.		2023
36894706	Major cell-types in multiomic single-nucleus datasets impact statistical modeling of links between regulatory sequences and target genes.		2023
37451613	Association Analyses of Predicted Loss-of-Function Variants Prioritized 15 Genes as Blood Pressure Regulators.		2023
36993181	Gene-metabolite annotation with shortest reactional distance enhances metabolite genome-wide association studies results.		2023
36928188	Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells.	PLoS Genet	2023
35138379	Transcriptome-wide association study in UK Biobank Europeans identifies associations with blood cell traits.	Hum Mol Genet	2022
35668299	One step closer to linking GWAS SNPs with the right genes.	Nature Genetics	2022
35352813	Importance of genetic testing in unexplained cardiac arrest.	Eur Heart J	2022
36400533	Genetic Modifiers of Sickle Cell Disease.	Hematology/Oncology Clinics of North America	2022
35273064	Cohort profile: genomic data for 26 622 individuals from the Canadian Longitudinal Study on Aging (CLSA).	BMJ Open	2022
34582791	Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program.	Am J Hum Genet	2021
33532840	Motif-Raptor: a cell type-specific and transcription factor centric approach for post-GWAS prioritization of causal regulators.		2021
34109777	A <i>Grammastola spatulata</i> mechanotoxin-4 (GsMTx4)-sensitive cation channel mediates increased cation permeability in human hereditary spherocytosis of multiple genetic etiologies.	Haematologica	2021
34270327	Transcriptomic Profiling of Canine Atrial Fibrillation Models After One Week of Sustained Arrhythmia.	Circulation: Arrhythmia and Electrophysiology	2021
34107879	Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) study.	BMC Genomics	2021
33887194	Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.	Am J Hum Genet	2021
34087167	Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.	Am J Hum Genet	2021
33713608	Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry.	Am J Hum Genet	2021
33495596	Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.	Nat Genet	2021
32949984	Potential causal role of l-glutamine in sickle cell disease painful crises: A Mendelian randomization analysis.	Blood Cells Mol Dis	2021
35047852	From GWAS variant to function: A study of â¿¼148,000 variants for blood cell traits.	HGG Adv	2021
34746258	Design of a Randomized Placebo-Controlled Trial to Evaluate the Anti-inflammatory and Senolytic Effects of Quercetin in Patients Undergoing Coronary Artery Bypass Graft Surgery.	Front Cardiovasc Med	2021
34521115	Clonal hematopoiesis in sickle cell disease.	Blood	2021
34517814	Correction to: Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) Study.	BMC Genomics	2021
34508877	Understanding the molecular events preceding and leading to atrial fibrillation.	Heart Rhythm	2021
30617275	Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.	Mol Psychiatry	2020
32142671	Blocking HbS Polymerization in SCD.	Cell	2020
32869539	A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy.	ESC Heart Fail	2020
32888494	The Polygenic and Monogenic Basis of Blood Traits and Diseases.	Cell	2020
32888493	Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.	Cell	2020
31308240	Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson's disease.	Proc Natl Acad Sci U S A	2019
30307499	Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans.	Hum Mol Genet	2019
31287004	Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene.		2019
31184202	Validation of Genome-Wide Polygenic Risk Scores for Coronary Artery Disease in French Canadians.	Circ Genom Precis Med	2019
31160809	Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.	Nat Genet	2019
29273807	Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.	Nat Genet	2018
28649937	The genetics of platelet count and volume in humans.	Platelets	2018
29884117	PHACTR1 splicing isoforms and eQTLs in atherosclerosis-relevant human cells.	BMC Medical Genetics	2018
30505949	White Paper: Pathways to Progress in Newborn Screening for Sickle Cell Disease in Sub-Saharan Africa.	J Trop Dis Public Health	2018
30105803	A common functional PIEZO1 deletion allele associates with red blood cell density in sickle cell disease patients.	American Journal of Hematology	2018
30289950	Lp-PLA2, scavenger receptor class B type I gene (SCARB1) rs10846744 variant, and cardiovascular disease.	PLoS One	2018
30369316	Variants at the APOE /C1/C2/C4 Locus Modulate Cholesterol Efflux Capacity Independently of High-Density Lipoprotein Cholesterol.	J Am Heart Assoc	2018
30410998	Sickle Cell Disease Clinical Trials and Phenotypes.	J Trop Dis Public Health	2018
29432581	14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts.	Hum Mol Genet	2018
29549330	Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.	Nat Genet	2018