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Author Details

Zhongwu Lai
Oncology R&D
1998
45
26
PMIDPaper TitleJournal TitlePublished Year
36043882Detection of BRCA1, BRCA2, and ATM Alterations in Matched Tumor Tissue and Circulating Tumor DNA in Patients with Prostate Cancer Screened in PROfound.Clin Cancer Res2023
37589839Identifying homologous recombination deficiency in breast cancer: genomic instability score distributions differ among breast cancer subtypes.Breast Cancer Res Treat2023
37517589Pan-Cancer Proteomics Analysis to Identify Tumor-Enriched and Highly Expressed Cell Surface Antigens as Potential Targets for Cancer Therapeutics.Mol Cell Proteomics2023
37390980Durvalumab in Combination With Olaparib Versus Durvalumab Alone as Maintenance Therapy in Metastatic NSCLC: The Phase 2 ORION Study.J Thorac Oncol2023
37146473Olaparib and durvalumab in patients with relapsed small cell lung cancer (MEDIOLA): An open-label, multicenter, phase 1/2, basket study.Lung Cancer2023
34645648Adavosertib with Chemotherapy in Patients with Primary Platinum-Resistant Ovarian, Fallopian Tube, or Peritoneal Cancer: An Open-Label, Four-Arm, Phase II Study.Clin Cancer Res2022
35394676Uncovering variable neoplasms between ATM protein-truncating and common missense variants using 394â¿¿694 UK Biobank exomes.Genes Chromosomes Cancer2022
35921524Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance.Clin Cancer Res2022
34979999Landscape of homologous recombination deficiencies in solid tumours: analyses of two independent genomic datasets.BMC Cancer2022
34830984Homologous Recombination Repair Gene Mutation Characterization by Liquid Biopsy: A Phase II Trial of Olaparib and Abiraterone in Metastatic Castrate-Resistant Prostate Cancer.Cancers (Basel)2021
34500047Analysis of mutation status and homologous recombination deficiency in tumors of patients with germline BRCA1 or BRCA2 mutations and metastatic breast cancer: OlympiAD.Ann Oncol2021
34742578Concordance of BRCA mutation detection in tumor versus blood, and frequency of bi-allelic loss of BRCA in tumors from patients in the phase III SOLO2 trial.Gynecol Oncol2021
32771088Olaparib and durvalumab in patients with germline BRCA-mutated metastatic breast cancer (MEDIOLA): an open-label, multicentre, phase 1/2, basket study.Lancet Oncol2020
29215764An evaluation of the challenges to developing tumor BRCA1 and BRCA2 testing methodologies for clinical practice.Hum Mutat2018
29941481The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer.Clin Cancer Res2018
30022119Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.Nat Cell Biol2018
30353044Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes.Br J Cancer2018
29528792Selumetinib in Combination With Dacarbazine in Patients With Metastatic Uveal Melanoma: A Phase III, Multicenter, Randomized Trial (SUMIT).J Clin Oncol2018
29635390RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.Ann Oncol2018
28525389Biological and clinical evidence for somatic mutations in BRCA1 and BRCA2 as predictive markers for olaparib response in high-grade serous ovarian cancers in the maintenance setting.Oncotarget2017
28223274Long-Term Responders on Olaparib Maintenance in High-Grade Serous Ovarian Cancer: Clinical and Molecular Characterization.Clin Cancer Res2017
28392986Prioritisation of structural variant calls in cancer genomes.PeerJ2017
27112209Defining actionable mutations for oncology therapeutic development.Nat Rev Cancer2016
26578606BubbleTree: an intuitive visualization to elucidate tumoral aneuploidy and clonality using next generation sequencing data.Nucleic Acids Res2016
27472462Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations.Oncotarget2016
27189703Next-generation sequencing identifies a novel ELAVL1-TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208.Leuk Lymphoma2016
27060149VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research.Nucleic Acids Res2016
26824321Differential regulation of mTOR signaling determines sensitivity to AKT inhibition in diffuse large B cell lymphoma.Oncotarget2016
25301847Reproducible, Quantitative, and Flexible Molecular Subtyping of Clinical DLBCL Samples Using the NanoString nCounter System.Clin Cancer Res2015
25870145Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models.Cancer Res2015
25939061Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M.Nat Med2015
23272696Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol.ACS Chem Biol2013
23895133Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1.ACS Chem Biol2013
12690205Human chromosome 7: DNA sequence and biology.Science2003
12040188A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.Science2002
12364791The genome sequence of the malaria mosquito Anopheles gambiae.Science2002
12364792Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster.Science2002
11181995The sequence of the human genome.Science2001
11473002Design of a compartmentalized shotgun assembler for the human genome.Bioinformatics2001
10731133A whole-genome assembly of Drosophila.Science2000
10984460Optical mapping of BAC clones from the human Y chromosome DAZ locus.Genome Res2000
10731132The genome sequence of Drosophila melanogaster.Science2000
10610179A shotgun optical map of the entire Plasmodium falciparum genome.Nat Genet1999
10022982Optical mapping of Plasmodium falciparum chromosome 2.Genome Res1999
9804551Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.Science1998
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Collaborators

Oncology R&D
Co-authored papers 16
The J. Craig Venter Institute
Co-authored papers 8
J. Craig Venter Institute
Co-authored papers 8
Case Western Reserve University School of Medicine
Co-authored papers 7
Euclid Diagnostics LLC
Co-authored papers 7
The J. Craig Venter Institute.
Co-authored papers 6
Illumina Inc.
Co-authored papers 6
Center for Computational Biology, Johns Hopkins School of Medicine
Co-authored papers 6
Max Planck Institute of Molecular Cell Biology and Genetics
Co-authored papers 6
Co-authored papers 6
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University of Utah
Co-authored papers 5
Center for Computational Biology, Johns Hopkins University
Co-authored papers 5
Zibo First Hospital
Co-authored papers 5
Present Address: Tempus Labs Inc.
Co-authored papers 5
Co-authored papers 5
J. Craig Venter Institute
Co-authored papers 5
BC Cancer Research Institute
Co-authored papers 5
Xuzhou Kuangshan Hospital
Co-authored papers 5
Institut fur Informatik, Freie Universitat Berlin
Co-authored papers 5
Co-authored papers 5
Michigan State University
Co-authored papers 4
College of Veterinary Medicine, Sichuan Agricultural University
Co-authored papers 4
Broad Institute of MIT and Harvard
Co-authored papers 4
Beijing University of Chinese Medicine
Co-authored papers 4
Flinders Medical Centre
Co-authored papers 4
University of Wisconsin-Madison
Co-authored papers 4
Mayo Clinic
Co-authored papers 4
GE Global Research Center
Co-authored papers 4
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