Author details

Full Name

Peter J Ratcliffe

Affiliation

ORCID

Career Start Year

1982

Papers

329

H Index

111

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36725335	Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma.		2023
37572852	Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells.		2023
35232980	Publisher Correction: Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation.	Scientific Reports	2022
36098684	A global view of the aspiring physician-scientist.	eLife	2022
36097292	Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer.	Nature Structural and Molecular Biology	2022
35624205	Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation.	Nat Immunol	2022
35930668	Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6.	Proceedings of the National Academy of Sciences of the United States of America	2022
35854097	Author Correction: Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation.	Nat Immunol	2022
35537551	Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins.	Journal of Biological Chemistry	2022
36384128	Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature.	Cell Rep	2022
35046429	Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation.	Scientific Reports	2022
34921056	Harveian Oration 2020: Elucidation of molecular oxygen sensing mechanisms in human cells: implications for medicine.	Clinical Medicine	2022
33451998	Erratum. Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion. Diabetes 2015;64:733-745.		2021
33852916	Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells.	Cell Reports	2021
33626887	Precisely Tuned Inhibition of HIF Prolyl Hydroxylases Is Key for Cardioprotection After Ischemia.	Circulation Research	2021
34155378	The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes.	Nature Genetics	2021
32668176	Endothelial Oxygen Sensing in Alveolar Maintenance.	American Journal of Respiratory and Critical Care Medicine	2020
31964803	Genetic basis of oxygen sensing in the carotid body: HIF2Î± and an isoform switch in cytochrome c oxidase subunit 4.	Science Signaling	2020
31690629	Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI.	Journal of Biological Chemistry	2020
31999648	Marked and rapid effects of pharmacological HIF-2Î± antagonism on hypoxic ventilatory control.	Journal of Clinical Investigation	2020
31751494	Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors.	ChemMedChem	2020
31162141	Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.	Journal of Clinical Investigation	2019
31822727	Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer.	Sci Rep	2019
30429208	Inherent DNA-binding specificities of the HIF-1Î± and HIF-2Î± transcription factors in chromatin.	EMBO Reports	2019
31488900	Mechanisms of hypoxia signalling: new implications for nephrology.	Nature Reviews Nephrology	2019
31500697	Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates.	eLife	2019
31273118	Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.	Science	2019
29950663	Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.	Nature Chemical Biology	2018
29059365	The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia.	Nucleic Acids Res	2018
29917232	PHD2 inactivation in Type I cells drives HIF-2Î±-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies.	Journal of Physiology	2018
29915238	The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.	Nature Chemical Biology	2018
30333145	Nuclear entry and export of FIH are mediated by HIF1Î± and exportin1, respectively.	Journal of Cell Science	2018
28315322	New horizons in hypoxia signaling pathways.	Experimental Cell Research	2017
28805660	Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.	Journal of Clinical Investigation	2017
28715484	Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.	PLoS Genetics	2017
28352643	Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics.	Hypoxia (Auckl)	2017
28257692	A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism.	American Journal of Human Genetics	2017
27774982	Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer.	Nature Communications	2016
27060169	Adult hematopoietic stem cells lacking Hif-1Î± self-renew normally.	Blood	2016
27103577	On the pivotal role of PPARÎ± in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.	FASEB Journal	2016
27140401	Clinical iron deficiency disturbs normal human responses to hypoxia.	Journal of Clinical Investigation	2016
26791432	Pharmacological targeting of the HIF hydroxylases--A new field in medicine development.	Molecular Aspects of Medicine	2016
26298207	Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer.	Eur Urol	2016
26337139	Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway.	Journal of Physiology	2016
27800509	Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice.		2016
27651169	Gene panel sequencing improves the diagnostic work-up of patients with idiopathic erythrocytosis and identifies new mutations.	Haematologica	2016
27693047	Expression of Idh1 in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.	Cancer Cell	2016
27561929	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.	Nature Communications	2016
27506891	Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters.	EMBO Reports	2016
27502280	Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases.	J Biol Chem	2016