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Author Details

Todd M Brusko
College of Medicine, Diabetes Institute, University of Florida
2003
131
44
PMIDPaper TitleJournal TitlePublished Year
37888801Diabetes Study of Children of Diverse Ethnicity and Race: Study design.Diabetes Metab Res Rev2024
38079221NADPH Oxidase 2-Derived Reactive Oxygen Species Promote CD8+ T Cell Effector Function.J Immunol2024
36282337Milder loss of insulin-containing islets in individuals with type 1 diabetes and type 2 diabetes-associated TCF7L2 genetic variants.Diabetologia2023
37594278Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells.J Immunol2023
37625150Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability.Diabetes2023
37498686Human immune phenotyping reveals accelerated aging in type 1 diabetes.JCI Insight2023
37460638Induction of bronchus-associated lymphoid tissue is an early life adaptation for promoting human B cell immunity.Nat Immunol2023
37325626Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8<sup>+</sup> T cells.Front Immunol2023
37421943Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood.Immunity2023
37237059A genomic data archive from the Network for Pancreatic Organ donors with Diabetes.Sci Data2023
37432736Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes.JCI Insight2023
37332366<i>DHCR7</i> Expression Predicts Poor Outcomes and Mortality From Sepsis.Crit Care Explor2023
36082558Biomaterials-based nanoparticles conjugated to regulatory T cells provide a modular system for localized delivery of pharmacotherapeutic agents.J Biomed Mater Res A2023
35025103Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.Eur J Immunol2022
35693814Human CD4<sup>+</sup>CD25<sup>+</sup>CD226<sup>-</sup> Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4<sup>+</sup>CD25<sup>+</sup>CD127<sup>lo/-</sup> Tregs for Adoptive Cell Therapy.Front Immunol2022
35043156Improving the Prediction of Type 1 Diabetes Across Ancestries.Diabetes Care2022
33021571Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study.Shock2021
33545036TCR<sup>+</sup>/BCR<sup>+</sup> dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes.Cell2021
33483996De-coding genetic risk variants in type 1 diabetes.Immunol Cell Biol2021
33920038Lipid and Lipoprotein Dysregulation in Sepsis: Clinical and Mechanistic Insights into Chronic Critical Illness.J Clin Med2021
33632742Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report.Diabetes2021
34890254Infant T cells are developmentally adapted for robust lung immune responses through enhanced T cell receptor signaling.Sci Immunol2021
34858326Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes.Front Endocrinol (Lausanne)2021
34852222Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex.Cell Rep2021
34872616geneBasis: an iterative approach for unsupervised selection of targeted gene panels from scRNA-seq.Genome Biol2021
34618554SARS-CoV-2 infection generates tissue-localized immunological memory in humans.Sci Immunol2021
34806648Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes.JCI Insight2021
34603322The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes.Front Immunol2021
34721308Editorial: Footprints of Immune Cells in the Type 1 Diabetic Pancreas.Front Endocrinol (Lausanne)2021
34484194A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis.Front Immunol2021
34535154A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes.Crit Care2021
34620616Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes.Diabetes2021
33940160CAR- and TRuC-redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII.Mol Ther2021
34301848Overexpression of the <i>PTPN22</i> Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4<sup>+</sup> T Cell Activation.J Immunol2021
34326233Strategies for durable β cell replacement in type 1 diabetes.Science2021
34156979Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.JCI Insight2021
33419759Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis.Diabetes2021
33441381Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.Diabetes2021
32229538Characterization of Proinsulin T Cell Epitopes Restricted by Type 1 Diabetes-Associated HLA Class II Molecules.J Immunol2020
31959869Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis.Sci Rep2020
31826866Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis.Diabetes2020
32035746Innate inflammation drives NK cell activation to impair Treg activity.J Autoimmun2020
33113547A Novel Mutation in Insulin-Like Growth Factor 1 Receptor (c.641-2A&gt;G) Is Associated with Impaired Growth, Hypoglycemia, and Modified Immune Phenotypes.Horm Res Paediatr2020
33193362Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype <i>In Vitro</i> and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses.Front Immunol2020
33007439Immunophenotyping reveals distinct subgroups of lupus patients based on their activated T cell subsets.Clin Immunol2020
32833543Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes.Diabetes Technol Ther2020
32634859Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.Diabet Med2020
33013915CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.Front Immunol2020
32868408CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice.J Immunol2020
32273533Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice.Sci Rep2020
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Collaborators

Co-authored papers 44
College of Medicine, Diabetes Institute, University of Florida
Co-authored papers 17
University of Florida
Co-authored papers 13
University of Florida
Co-authored papers 10
University of Florida College of Medicine
Co-authored papers 9
University of Florida College of Medicine.
Co-authored papers 8
Co-authored papers 5
Co-authored papers 5
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 4
College of Medicine, University of Florida
Co-authored papers 3
University of Florida College of Medicine - Jacksonville
Co-authored papers 3
University of Florida Health
Co-authored papers 3
Forensic and Scientific Services
Co-authored papers 3
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 3
University of North Carolina at Chapel Hill
Co-authored papers 3
Columbia University
Co-authored papers 3
Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
Co-authored papers 3
University of Florida College of Medicine
Co-authored papers 3
USC/Children's Hospital Los Angeles Los Angeles California USA.
Co-authored papers 3
University of Florida
Co-authored papers 2
University of Florida College of Medicine
Co-authored papers 2
Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 2
College of Medicine, University of Florida
Co-authored papers 2
Co-authored papers 2
University of Florida, Univerzitet u Sarajevu Medicinski Fakultet
Co-authored papers 2
Institute on Aging, University of Florida
Co-authored papers 2
Co-authored papers 2
University of Florida
Co-authored papers 2
University of Florida.
Co-authored papers 2
University of Florida
Co-authored papers 2