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Author Details

Christopher J Langmead
Monash University
2000
131
36
PMIDPaper TitleJournal TitlePublished Year
36355830Opportunities and challenges for the development of M<sub>1</sub> muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits.Br J Pharmacol2024
37605621Molecular insights into orphan G protein-coupled receptors relevant to schizophrenia.Br J Pharmacol2024
36702158Structural and Molecular Determinants for Isoform Bias at Human Histamine H<sub>3</sub> Receptor Isoforms.ACS Chem Neurosci2023
37699762"We don't want to run before we walk": the attitudes of Australian stakeholders towards using psychedelics for mental health conditions.Public Health Res Pract2023
37679998Molecular and structural insights into the 5-HT<sub>2C</sub> receptor as a therapeutic target for substance use disorders.Br J Pharmacol2023
37337902Identifying promising sequences for protein engineering using a deep transformer protein language model.Proteins2023
37005377Targeting muscarinic receptors for the treatment of alcohol use disorders: Opportunities and hurdles for clinical development.Br J Pharmacol2023
36920855Building the foundation for a community-generated national research blueprint for inherited bleeding disorders: facilitating research through infrastructure, workforce, resources and funding.Expert Rev Hematol2023
36932159Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?Mol Psychiatry2023
34376825Binding of SEP-363856 within TAAR1 and the 5HT<sub>1A</sub> receptor: implications for the design of novel antipsychotic drugs.Mol Psychiatry2022
37881541<i>Gpr88</i> Deletion Impacts Motivational Control Without Overt Disruptions to Striatal Dopamine.Biol Psychiatry Glob Open Sci2022
35393394Beyond antipsychotics: a twenty-first century update for preclinical development of schizophrenia therapeutics.Transl Psychiatry2022
36812511Unifying cardiovascular modelling with deep reinforcement learning for uncertainty aware control of sepsis treatment.PLOS Digit Health2022
35125345Multipathway In Vitro Pharmacological Characterization of Specialized Proresolving G Protein-Coupled Receptors.Mol Pharmacol2022
35311018Trace Amine-Associated Receptor 1 (TAAR1): Molecular and Clinical Insights for the Treatment of Schizophrenia and Related Comorbidities.ACS Pharmacol Transl Sci2022
34962108M<sub>1</sub> muscarinic receptor activation decreases alcohol consumption via a reduction in consummatory behavior.Pharmacol Res Perspect2022
33955376A Novel 5-Cytokine Panel Outperforms Conventional Predictive Markers of Persistent Organ Failure in Acute Pancreatitis.Clin Transl Gastroenterol2021
33794760HARVESTMAN: a framework for hierarchical feature learning and selection from whole genome sequencing data.BMC Bioinformatics2021
33776771Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure.Front Pharmacol2021
34822784From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.Cell2021
34547628Cryo-EM structure of the dual incretin receptor agonist, peptide-19, in complex with the glucagon-like peptide-1 receptor.Biochem Biophys Res Commun2021
34782333Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms.BMJ Open Diabetes Res Care2021
34252975Asynchronous parallel Bayesian optimization for AI-driven cloud laboratories.Bioinformatics2021
33942300Muscarinic M<sub>4</sub> and M<sub>5</sub> receptors in the ventral subiculum differentially modulate alcohol seeking versus consumption in male alcohol-preferring rats.Br J Pharmacol2021
34351123Identification of a Novel Allosteric Site at the M<sub>5</sub> Muscarinic Acetylcholine Receptor.ACS Chem Neurosci2021
34210336Bayesian optimization with evolutionary and structure-based regularization for directed protein evolution.Algorithms Mol Biol2021
32259091New Advances in Targeting the Resolution of Inflammation: Implications for Specialized Pro-Resolving Mediator GPCR Drug Discovery.ACS Pharmacol Transl Sci2020
31881094Negative allosteric modulators of the human calcium-sensing receptor bind to overlapping and distinct sites within the 7-transmembrane domain.Br J Pharmacol2020
33344888Translation-Focused Approaches to GPCR Drug Discovery for Cognitive Impairments Associated with Schizophrenia.ACS Pharmacol Transl Sci2020
33027691Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.Mol Cell2020
32669442Structure-based development of a subtype-selective orexin 1 receptor antagonist.Proc Natl Acad Sci U S A2020
32416874Preface.Adv Pharmacol2020
32331824Acetylcholine Muscarinic M<sub>4</sub> Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents.Biol Psychiatry2020
32519845β-Arrestin-2-Dependent Mechanism of GPR52 Signaling in Frontal Cortical Neurons.ACS Chem Neurosci2020
32519838In the Loop: Extrastriatal Regulation of Spiny Projection Neurons by GPR52.ACS Chem Neurosci2020
30359639Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H<sub>3</sub> receptor antagonists.Neuropharmacology2019
31772027Crystal structure of the M<sub>5</sub> muscarinic acetylcholine receptor.Proc Natl Acad Sci U S A2019
31769019The importance of sex differences in pharmacology research.Br J Pharmacol2019
29080701G protein-coupled receptors as anabolic drug targets in osteoporosis.Pharmacol Ther2018
30302756Molecular pharmacology of GPCRs.Br J Pharmacol2018
29695609Bitopic Binding Mode of an M<sub>1</sub> Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes.Mol Pharmacol2018
29746559Comparative genotypic and phenotypic analysis of human peripheral blood monocytes and surrogate monocyte-like cell lines commonly used in metabolic disease research.PLoS One2018
29714810Divergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity.Br J Pharmacol2018
29683647Structure-Activity Relationships of Pan-Gα<sub>q/11</sub> Coupled Muscarinic Acetylcholine Receptor Positive Allosteric Modulators.ACS Chem Neurosci2018
29483658Muscarinic M<sub>5</sub> receptors modulate ethanol seeking in rats.Neuropsychopharmacology2018
29678111Discovery and Optimization of Potent and CNS Penetrant M<sub>5</sub>-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold.ACS Chem Neurosci2018
29185777Systematic Testing of Belief-Propagation Estimates for Absolute Free Energies in Atomistic Peptides and Proteins.J Chem Theory Comput2018
29233848G Protein-Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus.Pharmacol Rev2018
27864425Isoform-Specific Biased Agonism of Histamine H3 Receptor Agonists.Mol Pharmacol2017
27988276High throughput, quantitative analysis of human osteoclast differentiation and activity.Anal Biochem2017
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Collaborators

David C Whitcomb
University of Pittsburgh Medical Center
Co-authored papers 4
G Clermont
University of Pittsburgh
Co-authored papers 3
Jian Jin
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Co-authored papers 3
Georgios I Papachristou
The Ohio State University, Wexner Medical Center
Co-authored papers 3
Angela M Gronenborn
University of Pittsburgh
Co-authored papers 2
David A Case
Rutgers University
Co-authored papers 1
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The Microsoft Research University of Trento
Co-authored papers 1
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University of Pittsburgh
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Andrea Gogos
Co-authored papers 1
Mark A Febbraio
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Su-In Lee
University of Washington
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Peter Kolb
Institut fur Pharmazeutische Chemie, Philipps-Universitat Marburg
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David Swigon
University of Pittsburgh
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Alexandre Donz??
University of California berkeley
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Christopher Aiken
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Phil A Hart
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University of Alabama at Birmingham
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Qi Mi
University of Pittsburgh
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Roger J Lewis
Harbor-university of california los angeles Medical Center
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Dhiraj Yadav
University of Pittsburgh Medical Center
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William A Catterall
Co-authored papers 1
Carl Kingsford
Carnegie Mellon University
Co-authored papers 1
Judith Klein-Seetharaman
School of Molecular Sciences & College of Health Solutions, Arizona State University
Co-authored papers 1
Robert F Murphy
Carnegie Mellon University
Co-authored papers 1
Yoram Vodovotz
University of Pittsburgh
Co-authored papers 1
Brian B Haab
Co-authored papers 1
Peijun Zhang
Co-authored papers 1
Joel L Weissfeld
Co-authored papers 1
Release 1.2