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Author Details

Michael K Rosen
UT Southwestern Medical Center
1990
130
68
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36972455Quantitative reconstitution of yeast RNA processing bodies.Proc Natl Acad Sci U S A2023
37488172Molecular features driving condensate formation and gene expression by the BRD4-NUT fusion oncoprotein are overlapping but distinct.Sci Rep2023
37126554Coupling of protein condensates to ordered lipid domains determines functional membrane organization.Sci Adv2023
37214845Molecular features driving condensate formation and gene expression by the BRD4-NUT fusion oncoprotein are overlapping but distinct.bioRxiv2023
34772789Using quantitative reconstitution to investigate multicomponent condensates.RNA2022
35922507A mitotic chromatin phase transition prevents perforation by microtubules.Nature2022
35332323Bound nucleotide can control the dynamic architecture of monomeric actin.Nat Struct Mol Biol2022
35049497Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation.Elife2022
34986150Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity.PLoS One2022
33395293Structure-Function Properties in Disordered Condensates.J Phys Chem B2021
33692102Inhibition of CRISPR-Cas12a DNA targeting by nucleosomes and chromatin.Sci Adv2021
34035521Mechanistic dissection of increased enzymatic rate in a phase-separated compartment.Nat Chem Biol2021
33973848The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains.Elife2021
33169001A framework for understanding the functions of biomolecular condensates across scales.Nat Rev Mol Cell Biol2021
32451441Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein.Nat Cell Biol2020
32474299Karyopherins and condensates.Curr Opin Cell Biol2020
32553117A quantitative inventory of yeast P body proteins reveals principles of composition and specificity.Elife2020
30846599Stoichiometry controls activity of phase-separated clusters of actin signaling proteins.Science2019
31268421A composition-dependent molecular clutch between T cell signaling condensates and actin.Elife2019
31599693Phosphorylation of nephrin induces phase separated domains that move through actomyosin contraction.Mol Biol Cell2019
31543265Organization of Chromatin by Intrinsic and Regulated Phase Separation.Cell2019
31541396Improved strategy for isoleucine <sup>1</sup>H/<sup>13</sup>C methyl labeling in Pichia pastoris.J Biomol NMR2019
30951647Regulation of Transmembrane Signaling by Phase Separation.Annu Rev Biophys2019
29425497Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly.Cell Rep2018
30099028Who's In and Who's Out-Compositional Control of Biomolecular Condensates.J Mol Biol2018
29677513Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.Cell2018
28522495ATP controls the crowd.Science2017
28255696Reconstitution of TCR Signaling Using Supported Lipid Bilayers.Methods Mol Biol2017
28225081Biomolecular condensates: organizers of cellular biochemistry.Nat Rev Mol Cell Biol2017
29182244Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation.J Am Chem Soc2017
28949297Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites.Elife2017
29091028Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins.Elife2017
28924037Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs.J Biol Chem2017
26894386Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris.J Biomol NMR2016
27871362Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster.Elife2016
27827364Structural and mechanistic insights into regulation of the retromer coat by TBC1d5.Nat Commun2016
27392146Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein.Mol Cell2016
27374333Compositional Control of Phase-Separated Cellular Bodies.Cell2016
27459345Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives.J Am Chem Soc2016
26903538Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation.J Cell Biol2016
27056844Phase separation of signaling molecules promotes T cell receptor signal transduction.Science2016
27002172Correction: Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation.J Cell Biol2016
26947396Data publication with the structural biology data grid supports live analysis.Nat Commun2016
26025061Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris.J Biomol NMR2015
26412307Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins.Mol Cell2015
26553976Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck.Proc Natl Acad Sci U S A2015
24439376The WAVE regulatory complex links diverse receptors to the actin cytoskeleton.Cell2014
28903028Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation.Curr Biol2014
25203209Ena/VASP proteins cooperate with the WAVE complex to regulate the actin cytoskeleton.Dev Cell2014
25321392Phase transitions of multivalent proteins can promote clustering of membrane receptors.Elife2014
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Collaborators

CUNY Advanced Science Research Center
Co-authored papers 9
Co-authored papers 8
Broad Institute
Co-authored papers 7
University of Texas Southwestern Medical Center
Co-authored papers 7
University of Toronto
Co-authored papers 6
Howard Hughes Medical Institute, UT Southwestern Medical Center
Co-authored papers 6
Washington University School of Medicine
Co-authored papers 6
University of Georgia
Co-authored papers 5
University of Texas Southwestern Medical Center
Co-authored papers 5
UT Southwestern Medical Center
Co-authored papers 5
Co-authored papers 4
University of Texas Southwestern Medical Center
Co-authored papers 3
University of Texas Southwestern Medical Center
Co-authored papers 3
Washington University School of Medicine at St. Louis
Co-authored papers 3
University of California San Francisco
Co-authored papers 2
University of Texas Southwestern Medical Center
Co-authored papers 2
Co-authored papers 2
University of California san francisco
Co-authored papers 2
Bijvoet Center for Biomolecular Research, Utrecht University
Co-authored papers 2
University of Toronto, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 2
Lawrence Berkeley National Laboratory, University of California
Co-authored papers 2
Harvard University
Co-authored papers 2
Memorial Sloan-Kettering Cancer Center
Co-authored papers 2
Northwestern University
Co-authored papers 2
and Center for Structural Biology, Vanderbilt University
Co-authored papers 2
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)
Co-authored papers 2
University of Texas Southwestern Medical Center
Co-authored papers 1
Marine Biological Laboratory
Co-authored papers 1
The University of Sheffield
Co-authored papers 1
Dana-Farber Cancer Institute
Co-authored papers 1