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Author Details

Darwin S Linthicum
1970
124
27
PMIDPaper TitleJournal TitlePublished Year
26756394Three-dimensional structure, binding, and spectroscopic characteristics of the monoclonal antibody 43.1 directed to the carboxyphenyl moiety of fluorescein.Biopolymers2016
23920483Prodrugs of N-dicarboximide derivatives of the rat selective toxicant norbormide.Bioorganic and Medicinal Chemistry2013
22658693Design and synthesis of prodrugs of the rat selective toxicant norbormide.Bioorganic and Medicinal Chemistry2012
16026161Cocrystal structures of NC6.8 Fab identify key interactions for high potency sweetener recognition: implications for the design of synthetic sweeteners.Biochemistry2005
15231866Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells.Journal of Pharmacology and Experimental Therapeutics2004
12650829Early changes in metabolism of leukemic cell lines upon induction of apoptosis by cytotoxic drugs.European Journal of Pharmacology2003
11922754Combined use of regulatory elements within the cDNA to increase the production of a soluble mouse single-chain antibody, scFv, from tobacco cell suspension cultures.Protein Expression and Purification2002
11169615Cellular responses of NG108-15 and SK-N-MC lines to sweet and bitter tastants as measured by extracellular acidification rates.Journal of Neuroscience Research2001
11472232Antibody-ligand interactions: computational modeling and correlation with biophysical measurements.Combinatorial Chemistry and High Throughput Screening2001
11472231Antibody-based fluorescence polarization assay to screen combinatorial libraries for sweet taste compounds.Combinatorial Chemistry and High Throughput Screening2001
11949787Ultrastructural effects of silicic acid on primary lung fibroblasts in tissue culture.Tissue and Cell2001
11206460Dimeric beta-turn peptidomimetics as ligands for the neurotrophin receptor TrkC.Bioorganic and Medicinal Chemistry Letters2001
10797538Vasoactive amine responses in murine cerebrovascular endothelial cells as measured by extracellular acidification rates.Journal of Neuroscience Research2000
10694457Analysis of correlated motion in antibody combining sites from molecular dynamics simulations.Methods2000
10694449EditorialMethods2000
11257304Analysis of diversity of nucleotide and amino acid distributions in the VD and DJ joining regions in Ig heavy chains.Molecular Immunology2000
11120786CDK4 expression and activity are required for cytokine responsiveness in T cells.Journal of Immunology2000
10993728The three-dimensional structure of a complex of a murine Fab (NC10. 14) with a potent sweetener (NC174): an illustration of structural diversity in antigen recognition by immunoglobulins.J Mol Biol2000
10354424Ligand binding by antibody IgE Lb4: assessment of binding site preferences using microcalorimetry, docking, and free energy simulations.Biophysical Journal1999
10444003pH dependence of antibody: hapten association.Mol Immunol1999
10444001Conservation of cys-cys trp structural triads and their geometry in the protein domains of immunoglobulin superfamily members.Molecular Immunology1999
10440997Construction and characterization of two anti-sweetener single chain antibodies using radioligand binding, fluorescence and circular dichroism spectroscopy.Journal of Molecular Recognition1999
9871559A labeled guanidine ligand for studying sweet taste.Bioorganic and Medicinal Chemistry Letters1998
9786848Crystal structure of monoclonal 6B5 Fab complexed with phencyclidine.Journal of Biological Chemistry1998
9571052Ligand-induced domain movement in an antibody Fab: molecular dynamics studies confirm the unique domain movement observed experimentally for Fab NC6.8 upon complexation and reveal its segmental flexibility.Journal of Molecular Biology1998
9413272Nicotine induces leukocyte rolling and adhesion in the cerebral microcirculation of the mouse.Journal of Neuroimmunology1997
9587873Recognition of superpotent sweetener ligands by a library of monoclonal antibodies.Journal of Molecular Recognition1997
9354253Local histamine release increases leukocyte rolling in the cerebral microcirculation of the mouse.Brain Injury1997
9354243Libraries of opiate and anti-opiate peptidomimetics containing 2,3-methanoleucine.Bioorganic and Medicinal Chemistry1997
8573581Circular dichroism spectroscopy of monoclonal antibodies that bind a superpotent guanidinium sweetener ligand.Biochemistry1996
8872894Hypothesis: a possible role for mast cells and their inflammatory mediators in the pathogenesis of autoimmune encephalomyelitis.Journal of Neuroscience Research1996
9630894ABGEN: a knowledge-based automated approach for antibody structure modeling.Nat Biotechnol1996
9064282Molecular probes for sweeteners: immunorecognition of superpotent guanidinium compounds.1996
8799721Mast cell-derived histamine and tumour necrosis factor: differences between SJL/J and BALB/c inbred strains of mice.Immunology and Cell Biology1996
8756519Modeling the structure of the combining site of an antisweet taste ligand monoclonal antibody NC10.14.Biopolymers1996
8735668Microvascular leakage in mouse pial venules induced by bradykinin.Brain Injury1996
8649435Heteroligation of a mouse monoclonal IgE antibody (La2) with small molecules, analysed by computer-aided automated docking.Molecular Immunology1996
8519975Structural predictions of the binding site architecture for monoclonal antibody NC6.8 using computer-aided molecular modeling, ligand binding, and spectroscopy.Biophys J1995
24226794Fluorescence spectroscopy of monoclonal antibodies produced against the fluorescyl hapten conjugated through the xanthene ring.Journal of Fluorescence1995
7499504Expression of mRNA for 55-kDa and 75-kDa tumor necrosis factor (TNF) receptors in mouse cerebrovascular endothelium: effects of interleukin-1 beta, interferon-gamma and TNF-alpha on cultured cells.Journal of Neuroimmunology1995
7821748Intramolecular signaling upon complexation.FASEB Journal1995
7788557Absorption spectroscopy of the complexation between superpotent guanidinium sweeteners and specific monoclonal antibodies.International Journal of Biochemistry and Cell Biology1995
8089487Identification of residues in monoclonal antibody NC10.8 that bind to the sweetener N-(p-cyanophenyl)-N'-(diphenylmethyl)guanidinoacetic acid by using radioligand binding, absorption and fluorescence spectroscopy, computer-aided molecular modeling, and siJournal of Immunology1994
7893280Local and transmitted conformational changes on complexation of an anti-sweetener Fab.Journal of Molecular Biology1994
8190129Mechanism of allergenic cross-reactions--IV. Evidence for participation of aromatic residues in the ligand binding site of two multi-specific IgE monoclonal antibodies.Molecular Immunology1994
8188324Nucleotide sequence of the TNF type I receptor from a mouse endothelioma cell line.Immunogenetics1994
7945792Spectroscopic evidence for charge-transfer complexation in monoclonal antibodies that bind opiates.1994
7932796Histamine-induced microvascular leakage in pial venules: differences between the SJL/J and BALB/c inbred strains of mice.Journal of Neurotrauma1994
7696216Computer-aided molecular modeling of the binding site architecture for eight monoclonal antibodies that bind a high potency guanidinium sweetener.J Mol Graph1994
7686135Monoclonal antibodies to sweet taste proteins: II. Development of two different immunoassays for thaumatin and monellin.1993
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