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Author Details

Jeffrey Tze-Fei Wong
The Hong Kong University of Science and Technology
1961
101
32
PMIDPaper TitleJournal TitlePublished Year
32636606Descent of Bacteria and Eukarya From an Archaeal Root of Life.Evol Bioinform Online2020
28264473Future of the Genetic Code.Life (Basel)2017
26999216Coevolution Theory of the Genetic Code at Age Forty: Pathway to Translation and Synthetic Life.Life (Basel)2016
24572018Mutations enabling displacement of tryptophan by 4-fluorotryptophan as a canonical amino acid of the genetic code.Genome Biol Evol2014
24896340Emergence of life: from functional RNA selection to natural selection and beyond.Front Biosci (Landmark Ed)2014
21914441Effects of flavone 6-substitutions on GABAA receptors efficacy.Eur J Pharmacol2011
20808824Genetic code mutations: the breaking of a three billion year invariance.PLoS One2010
19841848Search for primitive Methanopyrus based on genetic distance between Val- and Ile-tRNA synthetases.J Mol Evol2009
18508609The genomics of LUCA.Front Biosci2008
17884304Polyphasic evidence delineating the root of life and roots of biological domains.Gene2007
17943131Genome-wide detection and characterization of positive selection in human populations.Nature2007
17943122A second generation human haplotype map of over 3.1 million SNPs.Nature2007
17611816Question 6: coevolution theory of the genetic code: a proven theory.Orig Life Evol Biosph2007
15770677Coevolution theory of the genetic code at age thirty.Bioessays2005
16153784Congruence of evidence for a Methanopyrus-proximal root of life based on transfer RNA and aminoacyl-tRNA synthetase genes.Gene2005
15177692Anticodon and wobble evolution.Gene2004
12801633Transfer RNA paralogs: evidence for genetic code-amino acid biosynthesis coevolution and an archaeal root of life.Gene2003
14637197Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands.Biochem Pharmacol2003
128183725,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties.Biochem Pharmacol2003
11919203NMR analysis of bovine tRNATrp: conformation dependence of Mg2+ binding.J Biol Chem2002
12561253Two flavones from Scutellaria baicalensis Georgi and their binding affinities to the benzodiazepine site of the GABAA receptor complex.Pharmazie2002
12392823Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi.Biochem Pharmacol2002
12494329Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex.Planta Med2002
11834741Recognition by tryptophanyl-tRNA synthetases of discriminator base on tRNATrp from three biological domains.J Biol Chem2002
113842343D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors.J Med Chem2001
10702225NMR studies of Bacillus subtilis tRNA(Trp) hyperexpressed in Escherichia coli. Assignment of imino proton signals and determination of thermal stability.J Biol Chem2000
8757806A concerted tryptophanyl-adenylate-dependent conformational change in Bacillus subtilis tryptophanyl-tRNA synthetase revealed by the fluorescence of Trp92.J Mol Biol1996
8950174Isolation and characterization of the Bacillus subtilis tryptophanyl-tRNA synthetase gene (trpS) conferring 5-fluorotryptophan resistance and temperature sensitivity.Biochim Biophys Acta1996
8879425Enhancement of erythrocyte sedimentation rate by polymerized hemoglobin.Artif Cells Blood Substit Immobil Biotechnol1996
8522205Interferon induction of human tryptophanyl-tRNA synthetase safeguards the synthesis of tryptophan-rich immune-system proteins: a hypothesis.Gene1995
7518888Preparation of conjugated hemoglobins.Methods Enzymol1994
8478922Crystallization of Bacillus subtilis tryptophanyl-tRNA synthetase.J Mol Biol1993
8491810Purification of hyperexpressed Bacillus subtilis tRNA(Trp) cloned in Escherichia coli.J Chromatogr1993
8486627Identity elements of tRNA(Trp). Identification and evolutionary conservation.J Biol Chem1993
1577751Mutational identification of an essential tryptophan in tryptophanyl-tRNA synthetase of Bacillus subtilis.J Biol Chem1992
10078288Properties of hemoglobin and dextran-hemoglobin rightshifted by oxidized inositol tetrakisphosphate.Artif Organs1992
1724560Origin of genetically encoded protein synthesis: a model based on selection for RNA peptidation.Orig Life Evol Biosph1991
2111710High-level expression of Bacillus subtilis tryptophanyl-tRNA synthetase in Escherichia coli.Biochem Cell Biol1990
2494170Tryptophanyl-tRNA synthetase from Bacillus subtilis. Characterization and role of hydrophobicity in substrate recognition.J Biol Chem1989
2460165Rightshifted dextran-hemoglobin as blood substitute.Biomater Artif Cells Artif Organs1988
3339272Impairment of renal function by stroma-free hemoglobin in rats.J Lab Clin Med1988
3124823Suppression of fluorescence of tryptophan residues in proteins by replacement with 4-fluorotryptophan.Biochem J1988
3079235Evolution of the genetic code.Microbiol Sci1988
3149612Cloning and nucleotide sequence of the structural gene coding for Bacillus subtilis tryptophanyl-tRNA synthetase.Gene1988
3592658Complementary base-pairing properties of cyclized and linear oligonucleotides.Arch Biochem Biophys1987
2426292Separation of tRNA by high-performance liquid chromatography at ambient temperature.J Chromatogr1986
3091367Natural selection versus primitive gene structure as determinant of codon usage.Eur J Biochem1986
2428789Biophysical basis of hypoxic radioprotection by deoxygenated dextran-hemoglobin.Int J Radiat Oncol Biol Phys1986
6200464Initial studies of hypoxic radioprotection by deoxygenated dextran-hemoglobin.Int J Radiat Oncol Biol Phys1984
6380688A highly thermostable proline:tRNA ligase from Thermus aquaticus. Purification and enzyme-tRNA recognition at elevated temperatures.Can J Biochem Cell Biol1984
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Collaborators

Hong Xue
Hong Kong University of Science and Technology
Co-authored papers 30
Stephen Kwok-Wing Tsui
The Chinese University of Hong Kong
Co-authored papers 3
Yangfan Liu
Co-authored papers 2
Jessica Roy
Co-authored papers 2
Jian-Bing Fan
Nanfang Hospital and Basic Medical College, Southern Medical University
Co-authored papers 2
Jean-Fran??ois Olivier
McGill University Health Center
Co-authored papers 2
Robert W Plumb
Co-authored papers 2
Ludmila Pawlikowska
Center for Cerebrovascular Research
Co-authored papers 2
David A Hinds
23andMe Inc.
Co-authored papers 2
Suzanne M Leal
Center for Statistical Genetics, Columbia University Medical Center
Co-authored papers 2
Thomas D Willis
Adaptive Biotechnologies
Co-authored papers 2
Li Jin
Fudan University
Co-authored papers 2
Jeffrey Barrett
Wellcome Trust Sanger Institute
Co-authored papers 2
E Clayton
Harvard Medical School, Vanderbilt University, Yale University Yale Law School
Co-authored papers 2
Hongbin Zhao
First Hospital of Xingtai
Co-authored papers 2
Fanny Chagnon
McGill University
Co-authored papers 2
Panos Deloukas
William Harvey Research Institute, Queen Mary University of London
Co-authored papers 2
Mark F Leppert
University of Utah
Co-authored papers 2
Chris Clee
Co-authored papers 2
Alexandre Montpetit
McGill University and Genome Quebec Innovation Centre
Co-authored papers 2
John W Belmont
Illumina Inc.
Co-authored papers 2
Ruth Jamieson
Newcastle University
Co-authored papers 2
Marcos Delgado
Co-authored papers 2
Michael Feolo
University of Massachusetts Medical School
Co-authored papers 2
IkeOluwapo O Ajayi
University of Ibadan
Co-authored papers 2
Emmanouil T Dermitzakis
University of Geneva
Co-authored papers 2
Pak C Sham
the University of Hong Kong
Co-authored papers 2
Charmaine D M Royal
Duke University
Co-authored papers 2
Hua Han
He Bei General Hospital
Co-authored papers 2
David J Cutler
Emory University School of Medicine
Co-authored papers 2
Release 1.2