Author details

Full Name

Kenneth J Holroyd

Affiliation

Center for Technology Transfer and Commercialization, Vanderbilt University

ORCID

Career Start Year

1988

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
34394194	Human and Machine Intelligence Together Drive Drug Repurposing in Rare Diseases.	Front Genet	2021
32112228	Leveraging Human Genetics to Identify Safety Signals Prior to Drug Marketing Approval and Clinical Use.	Drug Saf	2020
29218624	Motivation for Launching a Cancer Metastasis Inhibition (CMI) Program.	Target Oncol	2018
29788759	Advocating for mutually beneficial access to shelved compounds.	Future Med Chem	2018
29193979	When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data.	Assay Drug Dev Technol	2017
28379727	Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.	Assay Drug Dev Technol	2017
18990064	Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream.	Clin Infect Dis	2008
20525149	Up-Regulation of Interleukin-9 and the Interleukin-9-Associated Calcium-Activated Chloride Channel hCLCA1 in Nasal Mucosa Following In Vivo Allergen Challenge.	Allergy Asthma Clin Immunol	2007
15875066	Increased expression of the calcium-activated chloride channel hCLCA1 in airways of patients with obstructive chronic bronchitis.	Can Respir J	2005
15218996	Expression of HCLCA1 in cystic fibrosis lungs is associated with mucus overproduction.	Eur Respir J	2004
12855619	A Phase I and pharmacokinetic study of squalamine, an aminosterol angiogenesis inhibitor.	Clin Cancer Res	2003
14707832	Squalamine lactate reduces choroidal neovascularization in a laser-injury model in the rat.	Retina	2003
14519633	A phase I/IIA trial of continuous five-day infusion of squalamine lactate (MSI-1256F) plus carboplatin and paclitaxel in patients with advanced non-small cell lung cancer.	Clin Cancer Res	2003
12782818	Increased expression of interleukin-9, interleukin-9 receptor, and the calcium-activated chloride channel hCLCA1 in the upper airways of patients with cystic fibrosis.	Laryngoscope	2003
12476105	Effect of squalamine on iris neovascularization in monkeys.	Retina	2002
12647846	Microbiological profile of infected diabetic foot ulcers.	Diabet Med	2002
11751482	A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers.	Clin Cancer Res	2001
11360152	A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties.	Int J Obes Relat Metab Disord	2001
11297269	Squalamine treatment of human tumors in nu/nu mice enhances platinum-based chemotherapies.	Clin Cancer Res	2001
10629460	IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma.	J Allergy Clin Immunol	2000
10871433	Interleukin-9 receptor expression in asthmatic airways In vivo.	Lung	2000
10529881	In vitro susceptibility to pexiganan of bacteria isolated from infected diabetic foot ulcers.	Diagn Microbiol Infect Dis	1999
10427975	IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice.	Eur J Immunol	1999
10329852	IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders.	J Allergy Clin Immunol	1999
10103181	In vitro antibacterial properties of pexiganan, an analog of magainin.	Antimicrob Agents Chemother	1999
9727018	Molecular analysis of human interleukin-9 receptor transcripts in peripheral blood mononuclear cells. Identification of a splice variant encoding for a nonfunctional cell surface receptor.	J Biol Chem	1998
9806735	Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice.	Am J Respir Cell Mol Biol	1998
9782093	Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region.	Genomics	1998
9398854	Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice.	Nat Genet	1997
9371819	Interleukin 9: a candidate gene for asthma.	Proc Natl Acad Sci U S A	1997
9316494	Genetic modeling of susceptibility to nitrogen dioxide-induced lung injury in mice.	Am J Physiol	1997
7607699	Localization of the A3 adenosine receptor gene (ADORA3) to human chromosome 1p.	Genomics	1995
8590330	Fine-structure mapping of genes providing susceptibility to asthma on chromosome 5q31-q33.	Clin Exp Allergy	1995
7631971	Insertion of a lumbar drain using a pediatric central venous catheter guidewire.	Anesthesiology	1995
7668269	Evidence for two unlinked loci regulating total serum IgE levels.	Am J Hum Genet	1995
7666875	Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy.	N Engl J Med	1995
7943772	Coronary artery revascularization before abdominal aortic aneurysm surgery: a decision analytic approach.	Anesth Analg	1994
8342849	Intraarterial vasodilator administration to restore pulse oximeter function.	Anesthesiology	1993
8256245	Correction of glutathione deficiency in the lower respiratory tract of HIV seropositive individuals by glutathione aerosol treatment.	Thorax	1993
8380824	Activation of alveolar macrophages in asymptomatic HIV-infected individuals.	J Immunol	1993
1676780	Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis.	Lancet	1991
1905329	Organ specific cytokine therapy. Local activation of mononuclear phagocytes by delivery of an aerosol of recombinant interferon-gamma to the human lung.	J Clin Invest	1991
2110187	Increased numbers of T lymphocytes with gamma delta-positive antigen receptors in a subgroup of individuals with pulmonary sarcoidosis.	J Clin Invest	1990
1968559	Glutathione deficiency and HIV.	Lancet	1990
2141626	Diversity in junctional sequences associated with the common human V gamma 9 and V delta 2 gene segments in normal blood and lung compared with the limited diversity in a granulomatous disease.	J Exp Med	1990
2151899	Limited diversity of gamma delta T-cell antigen receptor junctional region sequences in individuals with sarcoidosis compared to broad diversity in normal subjects.	Trans Assoc Am Physicians	1990
2574255	Systemic glutathione deficiency in symptom-free HIV-seropositive individuals.	Lancet	1989
3189374	Streptobacillus moniliformis polyarthritis mimicking rheumatoid arthritis: an urban case of rat bite fever.	Am J Med	1988

1 - 48 of 48

Saurabh Aggarwal

University of Alabama at Birmingham

Career Start Year 2009

Number of shared co-authors 0

Paola Nicoletti

Icahn School of Medicine at Mount Sinai

Career Start Year 2005

Number of shared co-authors 1

John Kenneth Baillie

Roslin Institute, University of Edinburgh

Career Start Year 2005

Number of shared co-authors 1

Scott D Pope

Yale School of Medicine, USA Howard Hughes Medical Institute

Career Start Year 2005

Number of shared co-authors 0

Michelle S Harkins

University of New Mexico

Career Start Year 2003

Number of shared co-authors 5

Arun H S Kumar

Sher-i-Kashmir Institute of Medical Sciences

Career Start Year 2002

Number of shared co-authors 0

Sun-Hee Ahn

The Warren Alpert Medical School of Brown University/Rhode Island Hospital

Career Start Year 2002

Number of shared co-authors 0

Jyoti Gupta

Dr. Harvansh Singh Judge Institute of Dental Sciences and Hospital, Panjab University

Career Start Year 2001

Number of shared co-authors 0

Soledad Fernandez

McGill University

Career Start Year 2001

Number of shared co-authors 0

Vivian Lee

Keck School of Medicine of USC, University of Southern

Career Start Year 1999

Number of shared co-authors 0

Huy Nguyen

The University of Danang-University of Science and Technology

Career Start Year 1993

Number of shared co-authors 0

Andrea Hofmann

Institute of Human Genetics, University of Bonn and Department of Genomics

Career Start Year 1991

Number of shared co-authors 0

Iftikhar Ahmed

International Islamic University

Career Start Year 1990

Number of shared co-authors 0

Christopher P Austin

St. George's University Medical School

Career Start Year 1990

Number of shared co-authors 1

Peter W Marks

Center for Biologics Evaluation and Research

Career Start Year 1988

Number of shared co-authors 0

Pedro A Lamothe

Allergy and Critical Care Medicine Emory University School of Medicine

Career Start Year 1988

Number of shared co-authors 0

Manuel C Peitsch

Philip Morris International Research Laboratories Pte. Ltd

Career Start Year 1987

Number of shared co-authors 0

Wayne Conrad Liles

University of Washington

Career Start Year 1986

Number of shared co-authors 0

Kirk A Easley

Rollins School of Public Health, Emory University School of Medicine

Career Start Year 1984

Number of shared co-authors 0

Phuong Nguyen

Hoag Memorial Hospital Presbyterian

Career Start Year 1983

Number of shared co-authors 0

Daniel Cruz

University of California Los Angeles

Career Start Year 1982

Number of shared co-authors 0

Charles M Stein

Vanderbilt University School of Medicine

Career Start Year 1982

Number of shared co-authors 6

Wataru Ito

Niigata University of Health and Welfare

Career Start Year 1981

Number of shared co-authors 0

Emilia Mia Sordillo

Icahn School of Medicine at Mount Sinai

Career Start Year 1981

Number of shared co-authors 0

Judith D Goldberg

NYU Grossman School of Medicine

Career Start Year 1974

Number of shared co-authors 1

Scott T Weiss

Brigham and Women's Hospital, Harvard Medical School

Career Start Year 1972

Number of shared co-authors 4

Quang Nguyen

Center for Andrology and Sexual Medicine, Viet Duc University Hospital

Career Start Year 1970

Number of shared co-authors 0

Howard Levy

Howard Levy Consulting LLC

Career Start Year 1966

Number of shared co-authors 1

Gilbert S Omenn

and School of Public Health, University of Michigan ann arbor

Career Start Year 1965

Number of shared co-authors 1

Anthony P Monaco

Monash University

Career Start Year 1958

Number of shared co-authors 0

row(s) 1 - 30 of 30

Jill M Pulley

Vanderbilt University School of Medicine

Co-authored papers 6

Jana K Shirey-Rice

Vanderbilt University School of Medicine

Co-authored papers 6

Michael Zasloff

Enterin Research Institute Inc.

Co-authored papers 6

Rebecca N Jerome

12328Vanderbilt University Medical Center

Co-authored papers 6

Gordon R Bernard

Vanderbilt University

Co-authored papers 5

Nicole M Zaleski

Co-authored papers 5

Robert R Lavieri

Vanderbilt University Medical Center

Co-authored papers 4

David M Aronoff

Indiana University School of Medicine

Co-authored papers 3

Dan M Roden

Vanderbilt University Medical Center

Co-authored papers 2

Deborah A Meyers

Co-authored papers 2

Noel G McElvaney

Co-authored papers 2

Eugene R Bleecker

Co-authored papers 2

Joshua C Denny

Vanderbilt University

Co-authored papers 2

Leslie J Crofford

Vanderbilt University School of Medicine

Co-authored papers 2

Ingrid A Mayer

Vanderbilt University Medical Center

Co-authored papers 2

Talat Alp Ikizler

Vanderbilt University Medical Center

Co-authored papers 1

Ronald P Danis

University of Wisconsin, Wisconsin EyeKor Inc.

Co-authored papers 1

James C Jackson

Vanderbilt University Medical Center

Co-authored papers 1

Christopher J Lindsell

Duke University

Co-authored papers 1

Lisa Bastarache

Vanderbilt University Medical Center

Co-authored papers 1

Roy S Herbst

Yale School of Medicine

Co-authored papers 1

Meghan Morrison Joly

Vanderbilt University Medical Center

Co-authored papers 1

April Barnado

Vanderbilt University School of Medicine

Co-authored papers 1

Raymond C Harris

Vanderbilt University Medical Center

Co-authored papers 1

Alexander P Reiner

Co-authored papers 1

Jianfeng Xu

Co-authored papers 1

Harold P Lehmann

Johns Hopkins University School of Medicine

Co-authored papers 1

David A Edwards

Vanderbilt University Medical Center

Co-authored papers 1

Anup P Challa

Vanderbilt University

Co-authored papers 1

Daniel D Von Hoff

Co-authored papers 1

1 - 30

Author Details

Column Actions

Recommended Authors

Collaborators