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Author Details

Dyann F Wirth
The Broad Institute
1977
294
72
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36927839Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.Nat Commun2023
37961451Evaluating the performance of Plasmodium falciparum genetics for inferring National Malaria Control Program reported incidence in Senegal.Res Sq2023
37949851Malaria surveillance reveals parasite relatedness, signatures of selection, and correlates of transmission across Senegal.Nat Commun2023
37737220Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance.Elife2023
38045387Baseline malaria infection status and RTS,S/AS01E malaria vaccine efficacy.medRxiv2023
37131838Malaria surveillance reveals parasite relatedness, signatures of selection, and correlates of transmission across Senegal.medRxiv2023
37163114Two decades of molecular surveillance in Senegal reveal changes in known drug resistance mutations associated with historical drug use and seasonal malaria chemoprevention.medRxiv2023
34233174The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.Cell Chem Biol2022
35687594Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies.PLoS Pathog2022
36246152R H: a genetic metric for measuring intrahost Plasmodium falciparum relatedness and distinguishing cotransmission from superinfection.PNAS Nexus2022
36008486Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.Nat Commun2022
35149760Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance.Commun Biol2022
34348113Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.Cell Chem Biol2022
33436791Polymorphisms in Plasmodium falciparum dihydropteroate synthetase and dihydrofolate reductase genes in Nigerian children with uncomplicated malaria using high-resolution melting technique.Sci Rep2021
33648890MalDA, Accelerating Malaria Drug Discovery.Trends Parasitol2021
33820996A framework for microbiome science in public health.Nat Med2021
33534888Biomarkers to Distinguish Bacterial From Viral Pediatric Clinical Pneumonia in a Malaria-Endemic Setting.Clin Infect Dis2021
33608006Genomic investigation of atypical malaria cases in Kanel, northern Senegal.Malar J2021
34523908Prioritization of Molecular Targets for Antimalarial Drug Discovery.ACS Infect Dis2021
34333350Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations.Int J Parasitol Drugs Drug Resist2021
31875909Plasmodium falciparum Gametocyte Density and Infectivity in Peripheral Blood and Skin Tissue of Naturally Infected Parasite Carriers in Burkina Faso.J Infect Dis2021
33431225Breadth of humoral immune responses to the C-terminus of the circumsporozoite protein is associated with protective efficacy induced by the RTS,S malaria vaccine.Vaccine2021
33359205Polymorphisms in Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and multidrug-resistant gene 1 (Pfmdr-1) in Nigerian children 10 years post-adoption of artemisinin-based combination treatments.Int J Parasitol2021
32618255Evidence for Reduced Malaria Parasite Population after Application of Population-Level Antimalarial Drug Strategies in Southern Province, Zambia.Am J Trop Med Hyg2020
33370279Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum.PLoS Genet2020
33097045Genetic analysis reveals unique characteristics of Plasmodium falciparum parasite populations in Haiti.Malar J2020
32746830Genetic evidence for imported malaria and local transmission in Richard Toll, Senegal.Malar J2020
32958025Use of a Plasmodium vivax genetic barcode for genomic surveillance and parasite tracking in Sri Lanka.Malar J2020
30773881The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling.ACS Infect Dis2019
31801884In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model.Sci Transl Med2019
31849205Quantitative imaging of intraerythrocytic hemozoin by transient absorption microscopy.J Biomed Opt2019
31239364Reply to Velavan et al.: Polymorphisms of <i>pfcoronin</i> in natural populations: Implications for functional significance.Proc Natl Acad Sci U S A2019
31262308Detection of low-density Plasmodium falciparum infections using amplicon deep sequencing.Malar J2019
31311552Temporal changes in Plasmodium falciparum reticulocyte binding protein homolog 2b (PfRh2b) in Senegal and The Gambia.Malar J2019
29315306Modeling the genetic relatedness of Plasmodium falciparum parasites following meiotic recombination and cotransmission.PLoS Comput Biol2018
30009295Conformation-guided analogue design identifies potential antimalarial compounds through inhibition of mitochondrial respiration.Org Biomol Chem2018
30523084Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.Science2018
30420498Mutations in <i>Plasmodium falciparum</i> actin-binding protein coronin confer reduced artemisinin susceptibility.Proc Natl Acad Sci U S A2018
30558627Characterization of Plasmodium falciparum structure in Nigeria with malaria SNPs barcode.Malar J2018
29643376Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections.Nat Commun2018
29722884De Novo Mutations Resolve Disease Transmission Pathways in Clonal Malaria.Mol Biol Evol2018
29720620Plasmepsin II-III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum.Nat Commun2018
29439977Inactivation of Plasmepsins 2 and 3 Sensitizes Plasmodium falciparum to the Antimalarial Drug Piperaquine.Antimicrob Agents Chemother2018
29764422hmmIBD: software to infer pairwise identity by descent between haploid genotypes.Malar J2018
29739900Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection.mBio2018
29738740Transmission of molecularly undetectable circulating parasite clones leads to high infection complexity in mosquitoes post feeding.Int J Parasitol2018
29370810Global action for training in malaria elimination.Malar J2018
29336544Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum.ACS Infect Dis2018
29326268Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.Science2018
29325146Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance.J Infect Dis2018
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Collaborators

Harvard T.H. Chan School of Public Health
Co-authored papers 38
University of California San Diego
Co-authored papers 26
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
Co-authored papers 20
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Co-authored papers 17
Harvard University
Co-authored papers 17
Harvard Medical School, Blavatnik Institute
Co-authored papers 13
University of California San Diego
Co-authored papers 9
Genomics Institute of the Novartis Research Foundation
Co-authored papers 9
Co-authored papers 7
University of California San Diego
Co-authored papers 6
Kamuzu University of Health Sciences
Co-authored papers 6
University of California San Diego
Co-authored papers 6
Broad Institute
Co-authored papers 5
Kamuzu University of Health Sciences
Co-authored papers 5
Broad Institute of MIT and Harvard
Co-authored papers 5
Vanderbilt-Ingram Cancer Center, Vanderbilt University
Co-authored papers 5
a division of The Scripps Research Institute La Jolla
Co-authored papers 4
Columbia University Irving Medical Center
Co-authored papers 4
Broad Institute of MIT and Harvard
Co-authored papers 4
Broad Institute of MIT and Harvard
Co-authored papers 4
University of Science
Co-authored papers 4
Co-authored papers 3
Co-authored papers 3
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Co-authored papers 3
Broad Institute of MIT and Harvard
Co-authored papers 3
Broad Institute of MIT and Harvard
Co-authored papers 3
University of California
Co-authored papers 3
University of California
Co-authored papers 2
Co-authored papers 2
University of California san francisco
Co-authored papers 2