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Author Details

Joseph L Witztum
1976
472
142
PMIDPaper TitleJournal TitlePublished Year
36781985Apolipoprotein C3 induces inflammasome activation only in its delipidated form.Nat Immunol2023
38045410Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter.2023
37848630Oxidized phospholipids in cardiovascular disease.2023
37338713On-treatment platelet reactivity through the thromboxane A or P2Y12 platelet receptor pathways is not affected by pelacarsen.2023
37211249High immunoglobulin-M levels to oxidation-specific epitopes are associated with lower risk of acute myocardial infarction.2023
37164837APOC3 inhibition with volanesorsen reduces hepatic steatosis in patients with severe hypertriglyceridemia.2023
37100699Volanesorsen and triglyceride levels in familial chylomicronemia syndrome: Long-term efficacy and safety data from patients in an open-label extension trial.2023
35025993Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk.Eur Heart J2022
35902351Effect of olezarsen targeting APOC-III on lipoprotein size and particle number measured by NMR in patients with hypertriglyceridemia.J Clin Lipidol2022
35653195Interventional hepatic apoC-III knockdown improves atherosclerotic plaque stability and remodeling by triglyceride lowering.JCI insight2022
36008083Shared Mechanisms between Cardiovascular Disease and NAFLD.Semin Liver Dis2022
35688187Development and validation of an isoform-independent monoclonal antibody-based ELISA for measurement of lipoprotein(a).Journal of Lipid Research2022
35935999B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis.Frontiers in Immunology2022
36402670Assessment of efficacy and safety of volanesorsen for treatment of metabolic complications in patients with familial partial lipodystrophy: Results of the BROADEN study: Volanesorsen in FPLD; The BROADEN Study.Journal of Clinical Lipidology2022
35917178The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis.JCI Insight2022
35218041Bioactive lipids and metabolic syndrome-a symposium report.Annals of the New York Academy of Sciences2022
34696496Longitudinal Assessment of Lipoprotein(a) Levels in Perinatally HIV-Infected Children and Adolescents.Viruses2021
33798466Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.Lancet Diabetes and Endocrinology,The2021
33636163Novel method for quantification of lipoprotein(a)-cholesterol: implications for improving accuracy of LDL-C measurements.J Lipid Res2021
34278710Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice.Aging Cell2021
34102100Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8<sup>+</sup> T cells in tumors.Immunity2021
33872986Prevalence and influence of LPA gene variants and isoform size on the Lp(a)-lowering effect of pelacarsen.Atherosclerosis2021
32990984A Neutralizing Antibody Targeting Oxidized Phospholipids Promotes Bone Anabolism in Chow-Fed Young Adult Mice.Journal of Bone and Mineral Research2021
34846914Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.Circulation2021
31111151Statin therapy increases lipoprotein(a) levels.Eur Heart J2020
32029622An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.Science2020
32362324Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.Immunity2020
31893580Lipoprotein(a) Reduction in Persons with Cardiovascular Disease.New England Journal of Medicine2020
31893480Statins and increases in Lp(a): an inconvenient truth that needs attention.Eur Heart J2020
32054669ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis.Heart2020
32160811Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation.Circ Res2020
32043907Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia.Nucleic Acid Therapeutics2020
31761566Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis.Cell Metab2020
32641432Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a).J Lipid Res2020
32635160CD1d Selectively Down Regulates the Expression of the Oxidized Phospholipid-Specific E06 IgM Natural Antibody in Mice.Antibodies2020
32860031Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia.European Heart Journal2020
31549940Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis.Circulation Research2019
31777768Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles.Journal of the Endocrine Society2019
31676683Erratum: A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma.Journal of Lipid Research2019
31881148Volanesorsen, Familial Chylomicronemia Syndrome, and Thrombocytopenia. Reply.New England Journal of Medicine2019
31881147Volanesorsen, Familial Chylomicronemia Syndrome, and Thrombocytopenia.New England Journal of Medicine2019
32159096Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography.CJC Open2019
31551368Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis.J Lipid Res2019
30553772CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice.Mol Metab2019
30563909A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma.Journal of Lipid Research2019
29850765Reduction of myocardial ischaemia-reperfusion injury by inactivating oxidized phospholipids.Cardiovasc Res2019
31092690ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance.J Lipid Res2019
30968745Apolipoprotein Profiles in Very Preterm and Term-Born Preschool Children.Journal of the American Heart Association2019
31390500Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome.New England Journal of Medicine2019
30726759RNA-Targeted Therapeutics.2019
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