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Author Details

Peter S Linsley
8Benaroya Research Institute
1978
297
106
PMIDPaper TitleJournal TitlePublished Year
36920087Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial.Diabetes Care2023
36947816Investigating Thymic Epithelial Cell Diversity Using Systems Biology.J Immunol2023
37432736Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes.JCI Insight2023
36961507<i>PTPN22</i> R620W gene editing in T cells enhances low-avidity TCR responses.Elife2023
34816633Pcsk9 Deletion Promotes Murine Nonalcoholic Steatohepatitis and Hepatic Carcinogenesis: Role of Cholesterol.Hepatol Commun2022
36150059Innovative Designs and Logistical Considerations for Expedited Clinical Development of Combination Disease-Modifying Treatments for Type 1 Diabetes.Diabetes Care2022
35911690IL-6-Driven pSTAT1 Response Is Linked to T Cell Features Implicated in Early Immune Dysregulation.Front Immunol2022
36206462Evaluating the Immunopathogenesis of Diabetes After Acute Pancreatitis in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium.Pancreas2022
36197963Pancreatic islet-specific engineered T<sub>regs</sub> exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models.Sci Transl Med2022
36219765Erratum. Innovative Designs and Logistical Considerations for Expedited Clinical Development of Combination Disease-Modifying Treatments for Type 1 Diabetes. Diabetes Care 2022;45:2189-2201.Diabetes Care2022
35020411Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity.Sci Transl Med2022
33351781Exhausted-like CD8+ T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects.JCI Insight2021
33741606Uncovering Pathways to Personalized Therapies in Type 1 Diabetes.Diabetes2021
34806648Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes.JCI Insight2021
34124936The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4<sup>+</sup> T Cells via a Novel CDK8-GATA3-FOXP3 Pathway.Mol Cell Biol2021
31974109Inflammatory Cytokines Induce Sustained CTLA-4 Cell Surface Expression on Human MAIT Cells.Immunohorizons2020
31877114IRF5 genetic risk variants drive myeloid-specific IRF5 hyperactivation and presymptomatic SLE.JCI Insight2020
31815738Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression.J Clin Invest2020
30830868Cell type-specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes.JCI Insight2019
31671072A composite immune signature parallels disease progression across T1D subjects.JCI Insight2019
31801887The human tissue-resident CCR5<sup>+</sup> T cell compartment maintains protective and functional properties during inflammation.Sci Transl Med2019
29925930Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes.Genes Immun2019
31157632Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D.Curr Opin Endocrinol Diabetes Obes2019
30830871B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes.JCI Insight2019
29377961Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling.PLoS One2018
30232284Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes.JCI Insight2018
30534127Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers.Front Immunol2018
28576979Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations.J Immunol2017
28566371Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4<sup>+</sup> T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.J Immunol2017
28768806A phenotypically and functionally distinct human T<sub>H</sub>2 cell subpopulation is associated with allergic disorders.Sci Transl Med2017
28844471Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes.Cell Immunol2017
26949057Circulating innate lymphoid cells are differentially regulated in allergic and nonallergic subjects.J Allergy Clin Immunol2016
28664195Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes.Sci Immunol2016
26398410The Relationship of Immune Cell Signatures to Patient Survival Varies within and between Tumor Types.PLoS One2015
26653891MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data.Genome Biol2015
24612859A transcriptomic reporter assay employing neutrophils to measure immunogenic activity of septic patients' plasma.J Transl Med2014
25314013Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis.PLoS One2014
22392482Synthetic lethality of PARP inhibition in BRCA-network disrupted tumor cells is associated with interferon pathway activation and enhanced by interferon-γ.Apoptosis2012
22786893A multiplexed siRNA screening strategy to identify genes in the PARP pathway.J Biomol Screen2012
22740638Disease-linked microRNA-21 exhibits drastically reduced mRNA binding and silencing activity in healthy mouse liver.RNA2012
22623531Functional genomics identifies therapeutic targets for MYC-driven cancer.Proc Natl Acad Sci U S A2012
21412408Effect of Xpcl1 activation and p27(Kip1) loss on gene expression in murine lymphoma.PLoS One2011
21934098Pillars article: CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994. 1: 405-413.J Immunol2011
21555486miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice.J Exp Med2011
21325218Pillars article: long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 1996. 381: 434-438. 1996.J Immunol2011
21285516Comparison of different miR-21 inhibitor chemistries in a cardiac disease model.J Clin Invest2011
20043028Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application.Nat Rev Drug Discov2010
20529236Hidden reach of the micromanagers.BMC Biol2010
20423675The therapeutic potential of microRNA modulation.Discov Med2010
19190338Identification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses.Cancer Res2009
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Collaborators

Cate Speake
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 11
Vivian H Gersuk
Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 11
Carla J Greenbaum
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 10
Sarah Alice Long
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 10
Matthew J Dufort
Center for Systems Immunology, Benaroya Research Institute Seattle
Co-authored papers 8
Hannah A DeBerg
Benaroya Research Institute at Virginia Mason
Co-authored papers 8
Gerald T Nepom
Wash Benaroya Research Institute at Virginia Mason
Co-authored papers 8
Kevan C Herold
Yale University
Co-authored papers 7
Stephen H Friend
University of Oxford
Co-authored papers 6
Christopher B Wilson
Drukier Institute for Children's Health
Co-authored papers 5
Karen Cerosaletti
Center for Translational Immunology
Co-authored papers 5
Martin Prlic
Fred Hutchinson Cancer Research Center
Co-authored papers 5
Erik Wambre
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
Co-authored papers 4
Aaron N Chang
Baylor College of Medicine
Co-authored papers 4
Damien Chaussabel
Co-authored papers 4
Deborah J Lenschow
Co-authored papers 4
Mario G Rosasco
Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 4
Jane H Buckner
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 4
Raphael Gottardo
Fred Hutchinson Cancer Center
Co-authored papers 4
Marc Ferrer
National Institutes of Health, National Center for Advancing Translational Sciences
Co-authored papers 4
Fariba Barahmand-Pour
Benaroya Research Institute at Virginia Mason
Co-authored papers 4
Scott Presnell
Benaroya Research Institute
Co-authored papers 3
Jonathan M Green
Co-authored papers 3
Jerald P Radich
Fred Hutchinson Cancer Center
Co-authored papers 3
Gregory J Hannon
Co-authored papers 3
Kaitlin J Flynn
Center for Systems Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 3
Elisavet Serti
The Henry Jackson Foundation.
Co-authored papers 3
William W Kwok
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 3
Bernard Khor
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Co-authored papers 2
Theresa L Walunas
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Release 1.2