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Author Details

Jann N Sarkaria
1993
280
67
PMIDPaper TitleJournal TitlePublished Year
37509518MDM2 Inhibition in the Treatment of Glioblastoma: From Concept to Clinical Investigation.2023
35973817Translational significance of CDKN2A/B homozygous deletion in isocitrate dehydrogenase-mutant astrocytoma.Neuro Oncol2023
36288512Alliance A071401: Phase II Trial of Focal Adhesion Kinase Inhibition in Meningiomas With Somatic <i>NF2</i> Mutations.J Clin Oncol2023
37589827How Much is Enough? Impact of Efflux Transporters on Drug delivery Leading to Efficacy in the Treatment of Brain Tumors.2023
37828724Delivery versus potency in treating brain tumors: BI-907828, a MDM2-p53 antagonist with limited BBB penetration but significant in vivo efficacy in glioblastoma.2023
37654190CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxiaâ¿¿induced invasion and therapeutic resistance.2023
37902550GTP signaling links metabolism, DNA repair, and responses to genotoxic stress.2023
37638345Spectral flow cytometry identifies distinct nonneoplastic plasma extracellular vesicle phenotype in glioblastoma patients.2023
37967136Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1.2023
37773633Magnetic resonance imaging of iron metabolism with T2* mapping predicts an enhanced clinical response to pharmacological ascorbate in patients with GBM.2023
37090571GTP signaling links metabolism, DNA repair, and responses to genotoxic stress.2023
37340056Blood-brain barrier disruption defines the extracellular metabolome of live human high-grade gliomas.2023
37324218WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models.2023
37385378Dosimetric patterns of failure in the era of novel chemoradiotherapy in newly-diagnosed glioblastoma patients.2023
36865270Main Manuscript for Cell migration simulator-based biomarkers for glioblastoma.bioRxiv2023
37370649Targeted c-Myc Inhibition and Systemic Temozolomide Therapy Extend Survival in Glioblastoma Xenografts.2023
37239852Glycan Node Analysis Detects Varying Glycosaminoglycan Levels in Melanoma-Derived Extracellular Vesicles.2023
36732634Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy.Nat Cancer2023
34887255Factors Influencing Luciferase-Based Bioluminescent Imaging in Preclinical Models of Brain Tumor.Drug Metabolism and Disposition2022
36109186Perivascular Stromal Cells Instruct Glioblastoma Invasion, Proliferation, and Therapeutic Response within an Engineered Brain Perivascular Niche Model.Advanced Science2022
36104272Cardiopulmonary Toxicity Following Intensity-Modulated Proton Therapy (IMPT) Versus Intensity-Modulated Radiation Therapy (IMRT) for Stage III Non-Small Cell Lung Cancer.Clin Lung Cancer2022
35830573Phage Particles of Controlled Length and Genome for Targeted Glioblastoma Imaging and Therapeutic Delivery.ACS Nano2022
35820185Characterization of Transgenic NSG-SGM3 Mouse Model of Precision Radiation-Induced Chronic Hyposalivation.Radiat Res2022
35631512IL-13Rα2 Status Predicts GB-13 (IL13.E13K-PE4E) Efficacy in High-Grade Glioma.Pharmaceutics2022
35370138Central Nervous System Delivery of the Catalytic Subunit of DNA-Dependent Protein Kinase Inhibitor Peposertib as Radiosensitizer for Brain Metastases.Journal of Pharmacology and Experimental Therapeutics2022
36137710Central Nervous System Distribution of the Ataxia-Telangiectasia Mutated Kinase Inhibitor AZD1390: Implications for the Treatment of Brain Tumors.Journal of Pharmacology and Experimental Therapeutics2022
36071925Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenografts.Neuro-Oncology Advances2022
35486732Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy.Science advances2022
35795471Detection of temozolomide-induced hypermutation and response to PD-1 checkpoint inhibitor in recurrent glioblastoma.Neuro-Oncology Advances2022
36428586Modeling Therapy-Driven Evolution of Glioblastoma with Patient-Derived Xenografts.Cancers (Basel)2022
35915159EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation.Nat Cell Biol2022
34232318Preclinical modeling in glioblastoma patient-derived xenograft (GBM PDX) xenografts to guide clinical development of lisavanbulin-a novel tumor checkpoint controller targeting microtubules.Neuro Oncol2022
35040929massNet: integrated processing and classification of spatially resolved mass spectrometry data using deep learning for rapid tumor delineation.Bioinformatics2022
35040235The influence of the blood-brain barrier in the treatment of brain tumours.Journal of Internal Medicine2022
35231103RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma.Neuro-Oncology2022
35191501Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition.Molecular Cancer Research2022
34435883Matrix Hyaluronic Acid and Hypoxia Influence a CD133 Subset of Patient-Derived Glioblastoma Cells.Tissue Engineering - Part A.2022
34383057Multimodal platform for assessing drug distribution and response in clinical trials.Neuro Oncol2022
35134075The efficacy of an unrestricted cycling ketogenic diet in preclinical models of IDH wild-type and IDH mutant glioma.PLoS ONE2022
34818553Protein kinase C and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities.Cell Reports2021
33707748EGFRvIII tumorigenicity requires PDGFRA co-signaling and reveals therapeutic vulnerabilities in glioblastoma.Oncogene2021
34016623Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks.Cancer Res2021
34112916Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells.Communications Biology2021
33736874Efflux Limits Tumor Drug Delivery Despite Disrupted BBB.Trends in Pharmacological Sciences2021
34050676Heterogeneous delivery across the blood-brain barrier limits the efficacy of an EGFR-targeting antibody drug conjugate in glioblastoma.Neuro Oncol2021
33785646Efficacy of Tesevatinib in -Amplified Patient-Derived Xenograft Glioblastoma Models May Be Limited by Tissue Binding and Compensatory Signaling.Molecular Cancer Therapeutics2021
33524942Synthetic and systems biology principles in the design of programmable oncolytic virus immunotherapies for glioblastoma.Neurosurgical Focus2021
34107029Experimental design of preclinical experiments: number of PDX lines vs subsampling within PDX lines.Neuro-Oncology2021
33674749Aurora-A kinase oncogenic signaling mediates TGF-β-induced triple-negative breast cancer plasticity and chemoresistance.Oncogene2021
33771703Initial Results of a Phase 2 Trial of F-DOPA PET-Guided Dose-Escalated Radiation Therapy for Glioblastoma.International Journal of Radiation Oncology Biology Physics2021
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