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Author Details

Zbynek Bozdech
Nanyang Technological University
1996
79
41
PMIDPaper TitleJournal TitlePublished Year
36807520Genomic, transcriptomic, and metabolomic analysis of Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti-cancer metabolites.J Integr Plant Biol2023
37934560Genetic validation of <i>Pf</i>FKBP35 as an antimalarial drug target.Elife2023
37216290<i>Plasmodium falciparum</i> Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors.ACS Infect Dis2023
36696458Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum.PLoS Pathog2023
35557691Mediator Complex of the Malaria Parasite <i>Plasmodium falciparum</i> Associates with Evolutionarily Novel Subunits.ACS Omega2022
35705035Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target.Cell Rep2022
35347215Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response.Commun Biol2022
35637187Stochastic expression of invasion genes in Plasmodium falciparum schizonts.Nat Commun2022
34400833A heat-shock response regulated by the PfAP2-HS transcription factor protects human malaria parasites from febrile temperatures.Nat Microbiol2021
33483501Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival.Nat Commun2021
34863371The parasitophorous vacuole nutrient channel is critical for drug access in malaria parasites and modulates the artemisinin resistance fitness cost.Cell Host Microbe2021
32341577Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome.Nat Protoc2020
32071059Whole-Cell Phenotypic Screening of Medicines for Malaria Venture Pathogen Box Identifies Specific Inhibitors of <i>Plasmodium falciparum</i> Late-Stage Development and Egress.Antimicrob Agents Chemother2020
33036628A comprehensive RNA handling and transcriptomics guide for high-throughput processing of Plasmodium blood-stage samples.Malar J2020
30602534Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay.Sci Transl Med2019
31521613Transcriptome profiling reveals functional variation in Plasmodium falciparum parasites from controlled human malaria infection studies.EBioMedicine2019
29255304Adaptation of Plasmodium falciparum to its transmission environment.Nat Ecol Evol2018
30514877The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background.Nat Commun2018
29783949Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa.BMC Genomics2018
29503181Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites.Cell Host Microbe2018
29538461Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites.PLoS Pathog2018
28830512Histone 4 lysine 8 acetylation regulates proliferation and host-pathogen interaction in Plasmodium falciparum.Epigenetics Chromatin2017
28414071Epigenetic landscapes underlining global patterns of gene expression in the human malaria parasite, Plasmodium falciparum.Int J Parasitol2017
28622798Singapore Malaria Network Meeting (SingMalNet) 2016.Int J Parasitol2017
27033103DNA damage regulation and its role in drug-related phenotypes in the malaria parasites.Sci Rep2016
27322479Integrated analysis of the Plasmodium species transcriptome.EBioMedicine2016
27313266Declining Efficacy of Artemisinin Combination Therapy Against P. Falciparum Malaria on the Thai-Myanmar Border (2003-2013): The Role of Parasite Genetic Factors.Clin Infect Dis2016
26858037New insights into the Plasmodium vivax transcriptome using RNA-Seq.Sci Rep2016
25502316Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance.Science2015
26067602A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression.Cell Host Microbe2015
26169358A crucial piece in the puzzle of the artemisinin resistance mechanism in Plasmodium falciparum.Trends Parasitol2015
25880967Plasmodium knowlesi gene expression differs in ex vivo compared to in vitro blood-stage cultures.Malar J2015
25901609Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance.PLoS Biol2015
24372851Structural polymorphism in the promoter of pfmrp2 confers Plasmodium falciparum tolerance to quinoline drugs.Mol Microbiol2014
25373614Genome-wide analysis in Plasmodium falciparum reveals early and late phases of RNA polymerase II occupancy during the infectious cycle.BMC Genomics2014
25075834Spread of artemisinin resistance in Plasmodium falciparum malaria.N Engl J Med2014
25121746Heterochromatin protein 1 secures survival and transmission of malaria parasites.Cell Host Microbe2014
24945736Epigenetic memory takes center stage in the survival strategy of malaria parasites.Curr Opin Microbiol2014
24877144Role of calcium signaling in the transcriptional regulation of the apicoplast genome of Plasmodium falciparum.Biomed Res Int2014
22990779DNA microarray-based genome-wide analyses of Plasmodium parasites.Methods Mol Biol2013
23615863A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria.Sci Rep2013
23468622Dynamic epigenetic regulation of gene expression during the life cycle of malaria parasite Plasmodium falciparum.PLoS Pathog2013
23373537H2A.Z and H2B.Z double-variant nucleosomes define intergenic regions and dynamically occupy var gene promoters in the malaria parasite Plasmodium falciparum.Mol Microbiol2013
22023809Quantitative proteomics reveals new insights into erythrocyte invasion by Plasmodium falciparum.Mol Cell Proteomics2012
22732921Identification of a new chemical class of antimalarials.J Infect Dis2012
22435676Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling.Mol Microbiol2012
22619330A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells.Proc Natl Acad Sci U S A2012
22415456Transcriptional variation in the malaria parasite Plasmodium falciparum.Genome Res2012
22384084Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors.PLoS One2012
21718533Design of a variant surface antigen-supplemented microarray chip for whole transcriptome analysis of multiple Plasmodium falciparum cytoadherent strains, and identification of strain-transcendent rif and stevor genes.Malar J2011
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Collaborators

Joseph L DeRisi
University of California San Francisco
Co-authored papers 6
Hagai Ginsburg
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Co-authored papers 4
Brian Pulliam
Harvard University Faculty of Arts and Sciences
Co-authored papers 2
Edith D Wong
Stanford University
Co-authored papers 2
Hendrik G Stunnenberg
Co-authored papers 2
P??r Nordlund
Karolinska Institutet, BioClinicum J6
Co-authored papers 2
Jingchun Zhu
University of California at Santa Cruz
Co-authored papers 2
Ross L Coppel
Nursing and Health SciencesMonash UniversityClaytonVictoriaAustralia.
Co-authored papers 1
Gaetan Burgio
College of Health and Medicine, The Australian National University
Co-authored papers 1
Fred E Cohen
University of California san francisco
Co-authored papers 1
Dhanasekaran Shanmugam
CSIR - National Chemical Laboratory
Co-authored papers 1
Aaron Shipway
Co-authored papers 1
Stuart A Ralph
Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Co-authored papers 1
Jennifer L Harris
Co-authored papers 1
David S Roos
University of Pennsylvania
Co-authored papers 1
Jane M Carlton
Center for Genomics and Systems Biology
Co-authored papers 1
Simon J Foote
Co-authored papers 1
Debashish Das
Co-authored papers 1
Alexander Schmidt
Co-authored papers 1
Marcin P Joachimiak
E O Lawrence Berkeley National Laboratory, UCSF Medical Center, University of California, Berkeley, University of Chicago
Co-authored papers 1
Kasturi Haldar
Boler-Parseghian Center for Rare and Neglected Disease, University of Notre Dame
Co-authored papers 1
Stephen L Hoffman
Inc., 9800 Medical Center Drive
Co-authored papers 1
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