Author details

Full Name

Timothy R D J Radstake

Affiliation

ORCID

Career Start Year

1998

Papers

361

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37543503	Multi-omics approach identifies PI3 as a biomarker for disease severity and hyper-keratinization in psoriasis.		2023
36171070	Deciphering the role of cDC2s in SjÃ¶gren's syndrome: transcriptomic profile links altered antigen processes with IFN signature and autoimmunity.	Annals of the Rheumatic Diseases	2023
36398888	HOXA5 is a key regulator of class 3 semaphorins expression in the synovium of rheumatoid arthritis patients.	Rheumatology	2023
37773045	TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance.	J Exp Med	2023
36512671	Efficacy and Safety of ABBV-3373, a Novel Anti-Tumor Necrosis Factor Glucocorticoid Receptor Modulator Antibody-Drug Conjugate, in Adults with Moderate-to-Severe Rheumatoid Arthritis Despite Methotrexate Therapy: A Randomized, Double-Blind, Active-Control		2023
36580032	Identification of Novel Associations and Localization of Signals in Idiopathic Inflammatory Myopathies Using Genome-Wide Imputation.	Arthritis Rheumatol	2023
37267106	Pyruvate metabolism controls chromatin remodeling during CD4 TÂ cell activation.		2023
36482877	Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+â¿¿Dendritic Cell Dysregulation in Systemic Sclerosis.	Arthritis Rheumatol	2023
37532471	Leflunomide/hydroxychloroquine combination therapy targets type I IFN-associated proteins in patients with SjÃ¶gren's syndrome that show potential to predict and monitor clinical response.		2023
35001548	Central Role of Semaphorin 3B in a Serum-Induced Arthritis Model and Reduced Levels in Patients With Rheumatoid Arthritis.	Arthritis and Rheumatology	2022
36245752	A Network of Serum Proteins Predict the Need for Systemic Immunomodulatory Therapy at Diagnosis in Noninfectious Uveitis.	Ophthalmol Sci	2022
36294335	The Effect of Body Fat Distribution on Systemic Sclerosis.	J Clin Med	2022
36444625	Differential isoform expression of Allergin-1 during acute and chronic inflammation.	Immunity, inflammation and disease	2022
36536476	Multi-omics integration reveals a core network involved in host defence and hyperkeratinization in psoriasis.		2022
34333017	ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts.		2022
34986347	CXCL4 drives fibrosis by promoting several key cellular and molecular processes.	Cell Reports	2022
35297512	Suppression of IL-12/IL-23 p40 subunit in the skin and blood of psoriasis patients by Tofacitinib is dependent on active interferon-Î³ signaling in dendritic cells: Implications for the treatment of psoriasis and interferon-driven diseases.	Experimental Dermatology	2022
35296555	Activation-induced colocalisation of SCAMP5 with IFNÎ± in human plasmacytoid dendritic cells.	Lupus Science and Medicine	2022
34559222	Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2Î±.	Rheumatology (Oxford)	2022
35017649	RegEnrich gene regulator enrichment analysis reveals a key role of the ETS transcription factor family in interferon signaling.	Communications Biology	2022
34413853	The Transcriptomic Profile of Monocytes from Patients With SjÃ¶gren's Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators.	Frontiers in Immunology	2021
36284900	DNAM1 and TIGIT balance the T cell response, with low T cell TIGIT expression corresponding to inflammation in psoriatic disease.		2021
32327425	EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors.	Annals of the Rheumatic Diseases	2021
33682325	Reply.	Arthritis and Rheumatology	2021
34108969	Integration of With Disease-Gene Network Reveals Common Cellular Mechanisms Between IMIDs and Drug Repurposing Strategies.	Frontiers in Immunology	2021
33573268	Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis.	J Clin Med	2021
33452865	Tissue-Resident Memory CD8+ T Cells From Skin Differentiate Psoriatic Arthritis From Psoriasis.	Arthritis and Rheumatology	2021
34096881	Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes.	Ann Rheum Dis	2021
33922041	Characterization of Long Non-Coding RNAs in Systemic Sclerosis Monocytes: A Potential Role for PSMB8-AS1 in Altered Cytokine Secretion.	International Journal of Molecular Sciences	2021
32797218	First-line csDMARD monotherapy drug retention in psoriatic arthritis: methotrexate outperforms sulfasalazine.	Rheumatology	2021
32909363	Multiomics and Machine Learning Accurately Predict Clinical Response to Adalimumab and Etanercept Therapy in Patients With Rheumatoid Arthritis.	Arthritis and Rheumatology	2021
32793974	Broad proteomic screen reveals shared serum proteomic signature in patients with psoriatic arthritis and psoriasis without arthritis.	Rheumatology	2021
33124151	Severe outcome of idiopathic inflammatory mass lesions primarily located in the posterior orbit and orbital apex.	Acta Ophthalmologica	2021
33004331	Genomic Risk Score impact on susceptibility to systemic sclerosis.	Ann Rheum Dis	2021
34386009	Transcriptome Analysis of CCR9+ T Helper Cells From Primary SjÃ¶gren's Syndrome Patients Identifies CCL5 as a Novel Effector Molecule.	Frontiers in Immunology	2021
34637328	Signaling by the inhibitory receptor CD200R is rewired by type I interferon.	Science Signaling	2021
31424086	Cytometry by time of flight identifies distinct signatures in patients with systemic sclerosis, systemic lupus erythematosus and SjÃ¶grens syndrome.	Eur J Immunol	2020
31970748	Novel insights into dendritic cells in the pathogenesis of systemic sclerosis.	Clinical and Experimental Immunology	2020
32198923	Impaired proteolysis by SPPL2a causes CD74 fragment accumulation that can be recognized by anti-CD74 autoantibodies in human ankylosing spondylitis.	Eur J Immunol	2020
31908355	Machine learning in rheumatology approaches the clinic.	Nature reviews. Rheumatology	2020
31841217	cDC2 and plasmacytoid dendritic cells diminish from tissues of patients with non-Hodgkin orbital lymphoma and idiopathic orbital inflammation.	European Journal of Immunology	2020
31840182	Extracellular SPARC cooperates with TGF-Î² signalling to induce pro-fibrotic activation of systemic sclerosis patient dermal fibroblasts.	Rheumatology	2020
31733111	Decreased circulating CXCR3Â +Â CCR9+T helper cells are associated with elevated levels of their ligands CXCL10 and CCL25 in the salivary gland of patients with SjÃ¶gren's syndrome to facilitate their concerted migration.	Scandinavian Journal of Immunology	2020
31783160	Emerging molecular biomarkers for predicting therapy response in psoriatic arthritis: A review of literature.	Clinical Immunology	2020
32345031	The Role of Th17/Treg Axis in the Traditional Chinese Medicine Intervention on Immune-Mediated Inflammatory Diseases: A Systematic Review.		2020
32226924	Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine.	Syst Med (New Rochelle)	2020
31713839	A pan-inflammatory microRNA-cluster is associated with orbital non-Hodgkin lymphoma and idiopathic orbital inflammation.	European Journal of Immunology	2020
32284212	CXCL4 triggers monocytes and macrophages to produce PDGF-BB, culminating in fibroblast activation: Implications for systemic sclerosis.	J Autoimmun	2020
32540951	Autoantigen /Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in SjÃ¶gren's syndrome is associated with B cell hyperactivity and type I interferon activity.	RMD Open	2020
33042130	Whole Transcriptome Analysis Reveals Heterogeneity in B Cell Memory Populations in Patients With Juvenile Idiopathic Arthritis-Associated Uveitis.	Frontiers in Immunology	2020